☆ 4.7 Review

Membranous nephropathy: Systems biology-based novel mechanism and traditional Chinese medicine therapy

FRONTIERS IN PHARMACOLOGY (2022)

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Article Chemistry, Multidisciplinary

Ginsenoside Rb1 alleviates diabetic kidney podocyte injury by inhibiting aldose reductase activity

Jia-yi He et al.

Summary: Panax notoginseng, a traditional Chinese medicine, has beneficial effects on diabetic kidney disease (DKD) by alleviating podocyte injury through inhibiting apoptosis and mitochondrial damage. Rb1, the main active ingredient of Panax notoginseng, combines with aldose reductase to effectively mitigate the progression of diabetic kidney disease.

ACTA PHARMACOLOGICA SINICA (2022)

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Article Pharmacology & Pharmacy

1-Hydroxypyrene mediates renal fibrosis through aryl hydrocarbon receptor signalling pathway

Hua Miao et al.

Summary: This study identified the role of 1-hydroxypyrene in mediating renal fibrosis in patients with chronic kidney disease. The findings suggest that targeting the aryl hydrocarbon receptor may be an alternative therapeutic strategy for CKD progression.

BRITISH JOURNAL OF PHARMACOLOGY (2022)

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Article Plant Sciences

Total coumarin derivates from Hydrangea paniculata attenuate renal injuries in cationized-BSA induced membranous nephropathy by inhibiting complement activation and interleukin 10-mediated interstitial fibrosis

Weida Wang et al.

Summary: The study evaluated the renal protective effect of Hydrangea Paniculata, Sieb (HP) in an experimental model of membranous nephritis (MN) and explored its underlying mechanisms. HP administration improved renal function, reduced dyslipidemia and histopathological injuries. mRNA sequencing indicated anti-inflammation and anti-fibrosis effects of HP, possibly through down-regulating the complement activation and PI3K-AKT pathways. Pharmacokinetic studies identified skimmin and 7-hydoxycoumarin (7-HC) as major compounds in HP. Inflammatory macrophage IL10 production was inhibited by skimmin and 7-HC through blocking PI3K-AKT and NF Kappa B signaling pathways. HP protected tubulointerstitium from complement attack by reducing C3 self-production and auto-cleavage in tubular cells.

PHYTOMEDICINE (2022)

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Article Pharmacology & Pharmacy

Efficacy and Safety of Different Immunosuppressive Therapies in Patients With Membranous Nephropathy and High PLA2R Antibody Titer

Le Deng et al.

Summary: This study evaluated clinical features and prognosis of patients with seropositive M-type phospholipase-A2-receptor (PLA2R)-associated membranous nephropathy (MN) based on different risk ranks. The results showed that patients with high titer PLA2Rab had more severe proteinuria and hypoalbuminemia, lower remission rates, and longer time to remission compared to those with non-high titer antibody. The study also found that PLA2Rab level at baseline was an independent predictive factor for remission.

FRONTIERS IN PHARMACOLOGY (2022)

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Article Pharmacology & Pharmacy

Real-World Effects of Chinese Herbal Medicine for Idiopathic Membranous Nephropathy (REACH-MN): Protocol of a Registry-Based Cohort Study

Lihong Yang et al.

Summary: This registry study aims to analyze the actual application of Chinese herbal medicine in the treatment of idiopathic membranous nephropathy and evaluate its clinical remission effect in Chinese population.

FRONTIERS IN PHARMACOLOGY (2022)

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Article Chemistry, Multidisciplinary

Wogonin protects glomerular podocytes by targeting Bcl-2-mediated autophagy and apoptosis in diabetic kidney disease

Xue-qi Liu et al.

Summary: Wogonin has been shown to alleviate glomerulopathy and podocyte injury in diabetic kidney disease (DKD) by regulating the Bcl-2-mediated crosstalk between autophagy and apoptosis. The study also demonstrated the inhibitory effects of wogonin on cellular damage and apoptosis induced by high glucose, as well as its promotion of autophagy in podocytes.

ACTA PHARMACOLOGICA SINICA (2022)

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Article Chemistry, Multidisciplinary

Intrarenal 1-methoxypyrene, an aryl hydrocarbon receptor agonist, mediates progressive tubulointerstitial fibrosis in mice

Gang Cao et al.

Summary: This study found that the metabolite 1-methoxypyrene (MP) activates the aryl hydrocarbon receptor (AhR) signaling pathway, leading to tubulointerstitial fibrosis (TIF). MP promotes the epithelial-mesenchymal transition and macrophage-myofibroblast transition, which are important for the development of TIF.

ACTA PHARMACOLOGICA SINICA (2022)

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Review Pharmacology & Pharmacy

TGF-β/Smad Signaling Pathway in Tubulointerstitial Fibrosis

Xiao-Yong Yu et al.

Summary: This review summarizes the role of TGF-beta/Smad signaling pathway in tubulointerstitial fibrosis and natural products that target this pathway for the treatment of fibrosis. Additionally, it presents challenges and opportunities for inhibiting renal fibrosis in the future.

FRONTIERS IN PHARMACOLOGY (2022)

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Review Pharmacology & Pharmacy

Recent Advances in Clinical Diagnosis and Pharmacotherapy Options of Membranous Nephropathy

Yan-Ni Wang et al.

Summary: Membranous nephropathy (MN) is a common cause of nephrotic syndrome and often recurs after kidney transplantation. The lack of sensitive biomarkers and effective therapies makes MN treatment challenging, but the discovery of PLA(2)R and THSD7A autoantibodies provides new insights.

FRONTIERS IN PHARMACOLOGY (2022)

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Article Urology & Nephrology

The clinicopathologic spectrum of segmental membranous glomerulopathy

Satoru Kudose et al.

Summary: Segmental membranous glomerulopathy (sMGN) is a rare PLA2R-negative variant of MGN with favorable prognosis, even in the absence of immunosuppressive treatment. During follow-up, most patients had stable/improved kidney function.

KIDNEY INTERNATIONAL (2021)

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Article Urology & Nephrology

Fumarate modulates phospholipase A2 receptor autoimmunity-induced podocyte injury in membranous nephropathy

Hyung Ah Jo et al.

Summary: The downstream mechanisms leading to podocyte injury following phospholipase A2 receptor (PLA2R) autoimmunity are still unclear. However, studies have found that fumarate may play a role in this process and could potentially serve as a target for the treatment of PLA2R-associated membranous nephropathy.

KIDNEY INTERNATIONAL (2021)

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Review Biochemistry & Molecular Biology

Gut microbiota-derived tryptophan metabolism mediates renal fibrosis by aryl hydrocarbon receptor signaling activation

Jing-Ru Liu et al.

Summary: The gut microbiota plays a crucial role in regulating intestinal immunity and maintaining homeostasis through metabolites derived from tryptophan metabolism. These metabolites can activate AHR signaling in various diseases, impacting disease progression such as inflammation, oxidative stress injury, and cardiovascular diseases.

CELLULAR AND MOLECULAR LIFE SCIENCES (2021)

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Article Medicine, General & Internal

Circ_0000524/miR-500a-5p/CXCL16 axis promotes podocyte apoptosis in membranous nephropathy

Zhiqiang Sun et al.

Summary: Upregulation of circ_0000524 and CXCL16, as well as low expression of miR-500a-5p, were observed in MN tissues. In cell experiments, circ_0000524 was found to regulate podocyte apoptosis through modulating miR-500a-5p and CXCL16.

EUROPEAN JOURNAL OF CLINICAL INVESTIGATION (2021)

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Article Biochemistry & Molecular Biology

Long non-coding RNAs: A double-edged sword in aging kidney and renal disease

Yan-Ni Wang et al.

Summary: Aging is a risk factor for chronic diseases, including kidney disease. Advances in genome analyses have identified noncoding RNAs, specifically lncRNAs, that play critical roles in the regulation of gene expression and epigenetic reprogramming, and have been shown to be important in kidney disease. Targeting lncRNAs may present a precise therapeutic strategy for progressive renal fibrosis.

CHEMICO-BIOLOGICAL INTERACTIONS (2021)

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Article Medicine, General & Internal

Renal expression of PLA2R, THSD7A, and IgG4 in patients with membranous nephropathy and correlation with clinical findings

Bulent Kaya et al.

Summary: The study found no correlation between PLA2R, THSD7A, and IgG4 staining in kidney tissue and treatment response. Interestingly, dual positivity (PLA2R + THSD7A) was detected only in primary MN patients.

INTERNATIONAL JOURNAL OF CLINICAL PRACTICE (2021)

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Article Urology & Nephrology

Clinical significance of glomerular C3 deposition in primary membranous nephropathy

Ozgur Akin Oto et al.

Summary: This study found that the extent of glomerular C3 deposition is associated with the development of kidney failure in patients with primary membranous nephropathy. Patients with high intensity C3 deposition had lower eGFR, higher proteinuria, and were more likely to experience kidney failure compared to those with low intensity C3 deposition.

JOURNAL OF NEPHROLOGY (2021)

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Review Cardiac & Cardiovascular Systems

Systems biology in cardiovascular disease: a multiomics approach

Abhishek Joshi et al.

Summary: Omics techniques generate large, multidimensional data that can be analyzed using informatics approaches and traditional statistical methods. Systems biology, utilizing network analysis and machine learning, addresses the complexity of biological processes. Novel approaches combining gene regulatory networks, proteomics, metabolomics, lipidomics, and phenomics with informatics techniques provide new insights into cardiovascular disease.

NATURE REVIEWS CARDIOLOGY (2021)

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Article Urology & Nephrology

Bioinformatic investigation for candidate genes and molecular mechanism in the pathogenesis of membranous nephropathy

Peng Li et al.

Summary: In this study, the detailed molecular mechanism of immune-associated genes in membranous nephropathy (MN) was explored using gene expression data and databases. Immune-related genes were identified and a protein-protein interaction network was constructed, revealing specific pathway and function enrichments. Predicted interactions between miRNAs and lncRNAs associated with the immune genes were also explored.

NEPHROLOGY (2021)

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Article Urology & Nephrology

Diagnostic performance of glomerular PLA2R and THSD7A antibodies in biopsy confirmed primary membranous nephropathy in South Africans

Bingileki F. Lwezaula et al.

Summary: The diagnostic performance of PLA2R and THSD7A in the diagnosis of primary membranous nephropathy (PMN) in South Africans was evaluated. The sensitivity of both tests together was higher than when used alone, indicating their potential diagnostic value in this population. The specificity and positive predictive values for any of the tests (alone or in combination) were 100%.

BMC NEPHROLOGY (2021)

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Review Chemistry, Multidisciplinary

Natural products: potential treatments for cisplatin-induced nephrotoxicity

Chun-yan Fang et al.

Summary: Cisplatin is a clinically advanced anticancer drug, but its severe nephrotoxic effects limit its clinical use. There are currently no effective drugs for cisplatin-induced kidney injury, but natural products may have potential therapeutic effects.

ACTA PHARMACOLOGICA SINICA (2021)

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Review Medicine, General & Internal

Advances in Membranous Nephropathy

Pierre Ronco et al.

Summary: Recent advances in the treatment and pathophysiology of membranous nephropathy have shed light on the competition between traditional cyclophosphamide therapy and rituximab, with substantial progress made in the last two years. This has led to a more personalized approach to medicine in the diagnosis and treatment of the disease.

JOURNAL OF CLINICAL MEDICINE (2021)

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Review Cell Biology

Perspectives in membranous nephropathy

Nicola M. Tomas et al.

Summary: The identification of key podocyte antigens in MN has revolutionized diagnosis and treatment, with novel animal models providing valuable insights. Serum autoantibody levels and kidney biopsy staining are now used globally to guide MN management. Despite significant progress, unanswered questions remain regarding disease mechanisms, clinical antibody measurement, and future treatments.

CELL AND TISSUE RESEARCH (2021)

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Article Pharmacology & Pharmacy

Shenkang Injection and Its Three Anthraquinones Ameliorates Renal Fibrosis by Simultaneous Targeting IκB/NF-κB and Keap1/Nrf2 Signaling Pathways

Liang-Pu Luo et al.

Summary: This study demonstrated for the first time that Shenkang injection (SKI) and its major components can protect against renal fibrosis by inhibiting oxidative stress and inflammation.

FRONTIERS IN PHARMACOLOGY (2021)

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Review Medicine, General & Internal

Membranous nephropathy

Pierre Ronco et al.

Summary: Membranous nephropathy (MN) is a glomerular disease that can occur at any age, with about 80% of adult patients having no apparent cause. It is an autoimmune disease with unpredictable disease outcome, with some patients experiencing spontaneous remission. Various treatment options are available, but relapses and suboptimal treatment responses remain a challenge.

NATURE REVIEWS DISEASE PRIMERS (2021)

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Article Medical Laboratory Technology

Altered expression of serum miR-106a, miR-19b, miR-17, and PTEN in patients with idiopathic membranous nephropathy

Lina Wu et al.

Summary: The study found that miR-106a, miR-19b, miR-17, and PTEN are involved in the pathogenesis of IMN and may serve as new biomarkers for the diagnosis of IMN.

JOURNAL OF CLINICAL LABORATORY ANALYSIS (2021)

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Article Medicine, Research & Experimental

Inhibition of the Wnt/β-catenin signaling pathway reduces autophagy levels in complement treated podocytes

Zhaocheng Dong et al.

Summary: In idiopathic membranous nephropathy, C5b-9 activates the Wnt/beta-catenin signaling pathway and promotes autophagy. The use of DKK1 as a blocker for the Wnt/beta-catenin pathway protects podocytes from injury and inhibits autophagy.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2021)

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Article Pharmacology & Pharmacy

Herbal Medicine Shulifenxiao Formula for Nephrotic Syndrome of Refractory Idiopathic Membranous Nephropathy

Hailan Cui et al.

Summary: This study retrospectively analyzed 31 RIMN patients resistant to corticosteroid or immunosuppressive agents and found that the Shulifenxiao formula had a good therapeutic effect, with high remission rates, reduced proteinuria, increased serum albumin, and improved eGFR in patients.

FRONTIERS IN PHARMACOLOGY (2021)

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Review Biochemistry & Molecular Biology

Mechanisms of Primary Membranous Nephropathy

Yan Gu et al.

Summary: Membranous nephropathy is an autoimmune disease affecting the kidney glomerulus, with around 30% of cases progressing to end-stage renal disease. Recent studies have identified the significance of autoantibodies like PLA2R and THSD7A in diagnosing and treating MN, while the discovery of new antigens like NELL-1 may further elucidate the full spectrum of PMN.

BIOMOLECULES (2021)

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Article Urology & Nephrology

Anti-PLA2R1 Antibodies as Prognostic Biomarker in Membranous Nephropathy

Anne-Els Van de Logt et al.

Summary: This study found a clear association between baseline anti-PLA2R1 antibody titer and severity of nephrotic syndrome in membranous nephropathy patients, but this association was no longer significant when considering proteinuria and serum creatinine in the analysis. The relevance of a single measurement of anti-PLA2R1 antibodies at baseline as a prognostic biomarker in membranous nephropathy is questioned, suggesting the need for future studies on sequential measurements for disease progression prediction.

KIDNEY INTERNATIONAL REPORTS (2021)

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Article Immunology

Comparison of 3 anti-PLA2R inmmunoassaysfor the diagnosis of idiopathic membranous nephropathy in an european population. A pilot study

Israel Nieto-Ganan et al.

Summary: Membranous nephropathy (MN) is a common cause of nephrotic syndrome, diagnosed by renal biopsy. This study compared three different techniques for detecting anti-PLA2R autoantibodies and found good consistency with new cut-off points. Patients with IMN had significantly lower serum albumin levels, and ELISA and Luminex assays were more useful than biochemical variables in differentiating IMN and SMN patients.

CLINICAL IMMUNOLOGY (2021)

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Article Multidisciplinary Sciences

Characterization of THSD7A-antibodies not binding to glomerular THSD7A in a patient with diabetes mellitus but no membranous nephropathy

Linda Reinhard et al.

Summary: For THSD7A-associated MN, kidney biopsy or Western blot analyses should be performed to confirm the diagnosis, especially in cases with low THSD7A-antibody levels in the IIFT.

SCIENTIFIC REPORTS (2021)

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Review Pharmacology & Pharmacy

Targeting the Wnt/β-Catenin Signaling Pathway as a Potential Therapeutic Strategy in Renal Tubulointerstitial Fibrosis

Shan-Shan Li et al.

Summary: The Wnt/β-catenin signaling pathway is crucial in renal fibrosis, controlling downstream mediators in various cell types and interacting with other pathways to promote fibrosis. Blocking this pathway may be beneficial for fibrosis treatment. Antagonists of Wnt signaling and small-molecule β-catenin inhibitors show potential therapeutic effects in preventing and treating renal fibrosis.

FRONTIERS IN PHARMACOLOGY (2021)

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Review Immunology

A Novel Insight into the Role of PLA2R and THSD7A in Membranous Nephropathy

Pingna Zhang et al.

Summary: Membranous nephropathy (MN) is an organ-restricted autoimmune disease primarily caused by circulating autoantibodies targeting podocyte antigens such as PLA2R and THSD7A. The factors triggering autoantibody production and the association with air pollution and malignancy are still unclear. This review provides new insights into the pathological mechanism of MN by discussing the similarities in pathological mechanisms triggered by different antigens.

JOURNAL OF IMMUNOLOGY RESEARCH (2021)

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Article Medicine, General & Internal

Clinical Phenotypes and Predictors of Remission in Primary Membranous Nephropathy

Roxana Jurubita et al.

Summary: In patients with primary membranous nephropathy, there are significant differences in clinical outcomes between those with PLA2R-related and PLA2R-negative pMN. Patients with PLA2R-negative pMN have a better clinical response. Baseline 24-hour proteinuria levels and immunological remission are important predictors of clinical response.

JOURNAL OF CLINICAL MEDICINE (2021)

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Article Urology & Nephrology

Fecal microbiota transplantation for membranous nephropathy

Guanzhou Zhou et al.

Summary: Membranous nephropathy is a type of nephrotic syndrome. Current treatments are not effective for all patients, and new therapies are needed. Gut microbiota may play a role in the pathogenesis of this disease, and fecal microbiota transplantation has shown potential in treatment.

CEN CASE REPORTS (2021)

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Article Urology & Nephrology

A novel mouse model of phospholipase A2 receptor 1-associated membranous nephropathy mimics podocyte injury in patients

Catherine Meyer-Schwesinger et al.

KIDNEY INTERNATIONAL (2020)

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Article Urology & Nephrology

Neural epidermal growth factor-like 1 protein (NELL-1) associated membranous nephropathy

Sanjeev Sethi et al.

KIDNEY INTERNATIONAL (2020)

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Article Chemistry, Multidisciplinary

Ganoderic acid hinders renal fibrosis via suppressing the TGF-β/Smad and MAPK signaling pathways

Xiao-qiang Geng et al.

ACTA PHARMACOLOGICA SINICA (2020)

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Article Chemistry, Multidisciplinary

Ganoderic acid A is the effective ingredient of Ganoderma triterpenes in retarding renal cyst development in polycystic kidney disease

Jia Meng et al.

ACTA PHARMACOLOGICA SINICA (2020)

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Antigens, antibodies, and membranous nephropathy: a decade of progress

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KIDNEY INTERNATIONAL (2020)

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Identification of endogenous 1-aminopyrene as a novel mediator of progressive chronic kidney disease via aryl hydrocarbon receptor activation

Hua Miao et al.

BRITISH JOURNAL OF PHARMACOLOGY (2020)

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Wenyang Lishui Decoction Ameliorates Podocyte Injury in Membranous Nephropathy Rat and Cell Models by Regulating p53 and Bcl-2

Huan Lu et al.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2020)

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Multitissue Multiomics Systems Biology to Dissect Complex Diseases

Xia Yang

TRENDS IN MOLECULAR MEDICINE (2020)

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Advances of the experimental models of idiopathic membranous nephropathy

Han Xue Jiang et al.

MOLECULAR MEDICINE REPORTS (2020)

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How Does Herbal Medicine Treat Idiopathic Membranous Nephropathy?

Zhendong Feng et al.

FRONTIERS IN PHARMACOLOGY (2020)

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Personalized Medicine for PLA2R1-Related Membranous Nephropathy: A Multicenter Randomized Control Trial

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FRONTIERS IN MEDICINE (2020)

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Advances in Pathogenesis of Idiopathic Membranous Nephropathy

Zhifeng Xu et al.

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Semaphorin 3B-associated membranous nephropathy is a distinct type of disease predominantly present in pediatric patients

Sanjeev Sethi et al.

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Dysbiosis of gut microbiota in adult idiopathic membranous nephropathy with nephrotic syndrome

Jun Zhang et al.

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A Comparative Study of the Gut Microbiota Associated With Immunoglobulin a Nephropathy and Membranous Nephropathy

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Hangxing Yu et al.

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Zhaocheng Dong et al.

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Alisol B 23-acetate attenuates CKD progression by regulating the renin-angiotensin system and gut-kidney axis

Hua Chen et al.

THERAPEUTIC ADVANCES IN CHRONIC DISEASE (2020)

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Article Biochemistry & Molecular Biology

Improvement of membranous nephropathy by inhibition of miR-193a to affect podocytosis via targeting WT1

Jiao Li et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2019)

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Microbiome-metabolome reveals the contribution of gut-kidney axis on kidney disease

Yuan-Yuan Chen et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2019)

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Article Urology & Nephrology

Novel ELISA for thrombospondin type 1 domain-containing 7A autoantibodies in membranous nephropathy

Christelle Zaghrini et al.

KIDNEY INTERNATIONAL (2019)

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Article Biochemistry & Molecular Biology

Activated NF-κB/Nrf2 and Wnt/β-catenin pathways are associated with lipid metabolism in CKD patients with microalbuminuria and macroalbuminuria

Ya-Long Feng et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2019)

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Article Medicine, Research & Experimental

Sanqi oral solution ameliorates renal damage and restores podocyte injury in experimental membranous nephropathy via suppression of NFκB

Ruimin Tian et al.

BIOMEDICINE & PHARMACOTHERAPY (2019)

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Article Biochemistry & Molecular Biology

Microbiome-metabolomics reveals gut microbiota associated with glycine-conjugated metabolites and polyamine metabolism in chronic kidney disease

Ya-Long Feng et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2019)

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Article Pathology

Features of phospholipase A2 receptor and thrombospondin type-1 domain-containing 7A in malignancy-associated membranous nephropathy

Changming Zhang et al.

JOURNAL OF CLINICAL PATHOLOGY (2019)

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Article Multidisciplinary Sciences

Identification of serum metabolites associating with chronic kidney disease progression and anti-fibrotic effect of 5-methoxytryptophan

Dan-Qian Chen et al.

NATURE COMMUNICATIONS (2019)

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Article Multidisciplinary Sciences

Low serum C3 level, high neutrophil-lymphocyte-ratio, and high platelet-lymphocyte-ratio all predicted poor long-term renal survivals in biopsy-confirmed idiopathic membranous nephropathy

Shang-Feng Tsai et al.

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Aryl hydrocarbon receptor ligands enhance lung immunity through intestinal IKKβ pathways

Tzyy-Bin Tsay et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2019)

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microRNAs in chronic kidney disease

Hui Zhao et al.

CLINICA CHIMICA ACTA (2019)

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Chronic kidney disease: a review of proteomic and metabolomic approaches to membranous glomerulonephritis, focal segmental glomerulosclerosis, and IgA nephropathy biomarkers

Amir Taherkhani et al.

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Metabolomic Analysis of Membranous Glomerulonephritis: Identification of a Diagnostic Panel and Pathogenic Pathways

Amir Taherkhani et al.

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Jolanta Kiewisz et al.

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Peptide GAM immunoadsorption therapy in primary membranous nephropathy (PRISM): Phase II trial investigating the safety and feasibility of peptide GAM immunoadsorption in anti-PLA2R positive primary membranous nephropathy

Patrick Hamilton et al.

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Efficacy of Traditional Chinese Medicine Regimen Jian Pi Qu Shi Formula for Refractory Patients with Idiopathic Membranous Nephropathy: A Retrospective Case-Series Study

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Asha Rani et al.

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Pierre Ronco et al.

BULLETIN DE L ACADEMIE NATIONALE DE MEDECINE (2017)

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Jessy J. Alexander et al.

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Review Immunology

Immunology of membranous nephropathy: from animal models to humans

R. A. Sinico et al.

CLINICAL AND EXPERIMENTAL IMMUNOLOGY (2016)

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Review Transplantation

The application of multi-omics and systems biology to identify therapeutic targets in chronic kidney disease

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Alternative Pathway Dysregulation and the Conundrum of Complement Activation by IgG4 Immune Complexes in Membranous Nephropathy

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Direct characterization of target podocyte antigens and auto-antibodies in human membranous glomerulonephritis: Alfa-enolase and borderline antigens

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Proteinuria induced by anti-dipeptidyl peptidase IV (gp108); role of circulating and glomerular antigen

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Treatment of idiopathic membranous nephropathy with the herb Astragalus membranaceus

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Serial changes in urinary proteome profile of membranous nephropathy: Implications for pathophysiology and biomarker discovery

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