4.7 Article

Network pharmacology-based investigation and experimental validation of the mechanism of scutellarin in the treatment of acute myeloid leukemia

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Chemistry, Multidisciplinary

Autophagy inhibitors increase the susceptibility of KRAS-mutant human colorectal cancer cells to a combined treatment of 2-deoxy-D-glucose and lovastatin

Xiao-ming Huang et al.

Summary: Combination treatment of glycolysis and oxidative phosphorylation inhibitors synergistically reduces cell viability and induces apoptosis in KRAS-mutant colorectal cancer cells. The treatment also decreases cellular oxygen consumption and ATP production, activating AMPK and inhibiting mTOR and RAS signaling pathways, ultimately inducing autophagy. Inhibition of autophagy enhances the cytotoxic effect of the combination therapy. These findings suggest a promising approach for managing RAS-driven colorectal cancers.

ACTA PHARMACOLOGICA SINICA (2021)

Article Health Care Sciences & Services

Scutellarin protects against diabetic cardiomyopathy via inhibiting oxidative stress and inflammatory response in mice

Lijiao Xu et al.

Summary: Scutellarin (Scu) protects against diabetic cardiomyopathy by improving cardiac function, reducing heart injury, inhibiting myocardial fibrosis, and increasing antioxidant enzyme activities in diabetic mice.

ANNALS OF PALLIATIVE MEDICINE (2021)

Article Biochemistry & Molecular Biology

Platyphyllenone Induces Autophagy and Apoptosis by Modulating the AKT and JNK Mitogen-Activated Protein Kinase Pathways in Oral Cancer Cells

Yen-Tze Liu et al.

Summary: Platyphyllenone can induce both autophagy and apoptosis in oral cancer cells by regulating multiple signaling pathways, providing a potential therapeutic option for chemoprevention against oral cancer proliferation.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Pharmacology & Pharmacy

Scutellarin Inhibits the Growth and EMT of Gastric Cancer Cells through Regulating PTEN/PI3K Pathway

Fu Li et al.

Summary: The study found that Scutellarin can dose-dependently inhibit the proliferation and metastasis of gastric cancer cells, promote apoptosis, and hinder tumor growth. Additionally, Scutellarin inhibits the PI3K pathway by increasing the expression of PTEN and reducing the phosphorylation level of PI3K, thus suppressing tumor progression.

BIOLOGICAL & PHARMACEUTICAL BULLETIN (2021)

Article Pharmacology & Pharmacy

Scutellarin ameliorates colitis-associated colorectal cancer by suppressing Wnt/β-catenin signaling cascade

Sha Zeng et al.

Summary: The study shows that Scutellarin can suppress colitis-associated cancer in mice by inhibiting the Wnt/β-catenin signaling pathway, leading to alleviation of pathological symptoms.

EUROPEAN JOURNAL OF PHARMACOLOGY (2021)

Article Integrative & Complementary Medicine

Serum Starvation Sensitizes Anticancer Effect of Anemarrhena asphodeloides via p38/JNK-Induced Cell Cycle Arrest and Apoptosis in Colorectal Cancer Cells

Kon-Young Ji et al.

Summary: This study demonstrates that the A. asphodeloides extract AA-Ex sensitively suppresses proliferation and induces apoptosis in serum-starved colorectal cancer cells. Treatment with AA-Ex also affects the cell survival signaling pathway and transcription factors. These findings suggest the therapeutic potential of AA-Ex for colon cancer treatment.

AMERICAN JOURNAL OF CHINESE MEDICINE (2021)

Article Biology

Scutellarin-induced A549 cell apoptosis depends on activation of the transforming growth factor-beta 1/smad2/ROS/caspase-3 pathway

Guang-Yan Zhang et al.

Summary: The study demonstrated that scutellarin significantly inhibited cell viability and increased apoptosis in A549 lung cancer cells. Scutellarin promoted intracellular ROS production, TGF-beta 1/smad2 signaling pathway activation, and cleaved caspase-3 expression, which could be partly reversed by Tempo treatment. Moreover, blocking the TGF-beta 1/smad2 pathway with SB431542 inhibited scutellarin-induced intracellular ROS production and cleaved caspase-3 expression.

OPEN LIFE SCIENCES (2021)

Review Integrative & Complementary Medicine

Network Pharmacology in Research of Chinese Medicine Formula: Methodology, Application and Prospective

Ting-ting Luo et al.

CHINESE JOURNAL OF INTEGRATIVE MEDICINE (2020)

Review Oncology

Targeting IDH Mutations in AML: Wielding the Double-edged Sword of Differentiation

Justin S. Becker et al.

CURRENT CANCER DRUG TARGETS (2020)

Article Biochemistry & Molecular Biology

Selective Activation of ZAK β Expression by 3-Hydroxy-2-Phenylchromone Inhibits Human Osteosarcoma Cells and Triggers Apoptosis via JNK Activation

Chien-Yao Fu et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Review Cell Biology

The JNK Signaling Pathway in Inflammatory Skin Disorders and Cancer

Manel B. Hammouda et al.

Article Education, Scientific Disciplines

Therapeutic development and current uses of BCL-2 inhibition

Andrew W. Roberts

HEMATOLOGY-AMERICAN SOCIETY OF HEMATOLOGY EDUCATION PROGRAM (2020)

Article Biochemistry & Molecular Biology

Polyphyllin I induces apoptosis and autophagy via modulating JNK and mTOR pathways in human acute myeloid leukemia cells

Ye Tian et al.

CHEMICO-BIOLOGICAL INTERACTIONS (2019)

Article Biotechnology & Applied Microbiology

Scutellarin inhibits the metastasis and cisplatin resistance in glioma cells

Shi-Lei Tang et al.

ONCOTARGETS AND THERAPY (2019)

Review Hematology

Hematopoietic stem cell transplantation for acute myeloid leukemia

Akiyoshi Takami

INTERNATIONAL JOURNAL OF HEMATOLOGY (2018)

Review Pharmacology & Pharmacy

Clinical benefits and pharmacology of scutellarin: A comprehensive review

Liping Wang et al.

PHARMACOLOGY & THERAPEUTICS (2018)

Review Medicine, General & Internal

Acute Myeloid Leukemia

Hartmut Doehner et al.

NEW ENGLAND JOURNAL OF MEDICINE (2015)

Article Chemistry, Medicinal

Scutellarin-Induced Apoptosis in HepG2 Hepatocellular Carcinoma Cells Via a STAT3 Pathway

Haitao Xu et al.

PHYTOTHERAPY RESEARCH (2013)

Review Biochemistry & Molecular Biology

JNK signaling in apoptosis

D. N. Dhanasekaran et al.

ONCOGENE (2008)