4.7 Review

The neuroprotective effects of fisetin, a natural flavonoid in neurodegenerative diseases: Focus on the role of oxidative stress

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Multidisciplinary Sciences

Turning chiral peptides into a racemic supraparticle to induce the self-degradation of MDM2

Wenguang Yang et al.

Summary: A mild and simple self-assembly strategy was developed for the construction of peptide-derived chiral supramolecular nanomedicine with suitable pharmaceutical properties. The study demonstrated the potential of chiral supramolecular nanomedicine in suppressing tumor progression and enhancing tumor immunotherapy.

JOURNAL OF ADVANCED RESEARCH (2023)

Review Environmental Sciences

Potential innovation against Alzheimer's disorder: a tricomponent combination of natural antioxidants (vitamin E, quercetin, and basil oil) and the development of its intranasal delivery

Chenmala Karthika et al.

Summary: Alzheimer's disorder is difficult to manage and treat due to the complexity of the brain and the blood-brain barrier. A combined strategy using a nano-based formulation containing vitamin E, quercetin, and basil oil, administered nasally, shows promise in treating and alleviating Alzheimer's disease. Intranasal drug administration is a non-invasive approach that enhances bioavailability and bypasses the blood-brain barrier, reducing systemic side effects.

ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH (2022)

Article Ophthalmology

Multimodal deep learning with feature level fusion for identification of choroidal neovascularization activity in age-related macular degeneration

Kai Jin et al.

Summary: This study utilized a multimodal deep learning model for the assessment of CNV in neovascular AMD, achieving comparable accuracy to retinal specialists. The FLF method proved to be feasible and highly accurate, with the model demonstrating potential for clinical use based on testing on external data sets.

ACTA OPHTHALMOLOGICA (2022)

Article Radiology, Nuclear Medicine & Medical Imaging

Accelerate gas diffusion-weighted MRI for lung morphometry with deep learning

Caohui Duan et al.

Summary: The study accelerated multiple b-value gas DW-MRI using deep learning, achieving high-quality reconstructions with faster speed. The DC-RDN demonstrated effectiveness in maintaining accurate estimation of lung microstructural morphometry, showing great potential for studying lung diseases in the future.

EUROPEAN RADIOLOGY (2022)

Review Biochemistry & Molecular Biology

Ferroptosis: A New Road towards Cancer Management

Iqra Bano et al.

Summary: Ferroptosis is a recently described programmed cell death mechanism that plays an important role in cancer treatment. Its initiation and sensitivity are related to factors such as suppression of Gpx4, cysteine deficiency, and AA peroxidation.

MOLECULES (2022)

Article Chemistry, Analytical

Sb-doped WO3 based QCM humidity sensor with self-recovery ability for real-time monitoring of respiration and wound

Zhijia Li et al.

Summary: Humidity sensing is a promising method for monitoring respiration and diagnosing diseases. In this study, a humidity sensor using Sb-doped WO3 nanocrystals was successfully fabricated. The sensor exhibited fast response and recovery times, high sensitivity, and good stability and self-recovery ability under wet conditions. It was also applied to monitor moisture changes of a wound, which was previously unexplored using this type of sensor.

SENSORS AND ACTUATORS B-CHEMICAL (2022)

Article Nutrition & Dietetics

Fisetin Suppresses the Inflammatory Response and Oxidative Stress in Bronchial Epithelial Cells

Shu-Ju Wu et al.

Summary: The study shows that fisetin can reduce the inflammatory response and oxidative stress in bronchial epithelial cells, and improve airway hyperresponsiveness in asthmatic mice. Fisetin decreases the levels of inflammatory cytokines and chemokines, as well as intercellular adhesion molecule-1 expression. It also suppresses monocyte adhesion and reduces eosinophil numbers. Moreover, fisetin promotes glutathione levels and decreases malondialdehyde levels in the lungs.

NUTRIENTS (2022)

Article Chemistry, Multidisciplinary

Gestational Leucylation Suppresses Embryonic T-Box Transcription Factor 5 Signal and Causes Congenital Heart Disease

Xuan Zhang et al.

Summary: Elevated maternal leucine levels are associated with an increased risk of congenital heart disease (CHD) in offspring. Increased leucine levels lead to embryonic lysine leucylation, inhibiting TBX5 signaling and contributing to CHD development.

ADVANCED SCIENCE (2022)

Article Chemistry, Multidisciplinary

Serum Metal Ion-Induced Cross-Linking of Photoelectrochemical Peptides and Circulating Proteins for Evaluating Cardiac Ischemia/Reperfusion

Panpan Hao et al.

Summary: Patients who have experienced the ischemia-reperfusion process are at a higher risk of subsequent heart attacks. A novel assay using synthetic small molecules for detecting free copper ions and cathepsin G in serum has shown potential for evaluating the severity and prognosis of cardiac ischemia/reperfusion.

ACS SENSORS (2022)

Article Cardiac & Cardiovascular Systems

Nicotinamide Mononucleotide Alleviates Cardiomyopathy Phenotypes Caused by Short-Chain Enoyl-Coa Hydratase 1 Deficiency

Ke Cai et al.

Summary: ECHS1 deficiency causes cardiac dysfunction through promoting p300 nuclear translocation and increasing H3K9 acetylation. Targeting acetylation can alleviate the cardiomyopathy phenotypes induced by ECHS1 deficiency.

JACC-BASIC TO TRANSLATIONAL SCIENCE (2022)

Review Gastroenterology & Hepatology

Shared decision-making in the management of patients with inflammatory bowel disease

Kai Song et al.

Summary: Shared decision-making plays a crucial role in the management of inflammatory bowel disease, improving patient satisfaction and treatment outcomes.

WORLD JOURNAL OF GASTROENTEROLOGY (2022)

Article Multidisciplinary Sciences

Instant diagnosis of gastroscopic biopsy via deep-learned single-shot femtosecond stimulated Raman histology

Zhijie Liu et al.

Summary: This study demonstrates a new imaging method, integrating femto-SRS technique with U-Net, for rapid and accurate diagnosis of gastric cancer. The method can diagnose gastric cancer without the need for pathologist-based diagnosis and holds potential for synchronizing with gastroscopic examination.

NATURE COMMUNICATIONS (2022)

Article Biochemistry & Molecular Biology

Discovering the Effects of Fisetin on NF-κB/NLRP-3/NRF-2 Molecular Pathways in a Mouse Model of Vascular Dementia Induced by Repeated Bilateral Carotid Occlusion

Marika Cordaro et al.

Summary: This study investigated the protective effects of fisetin in a mouse model of vascular dementia and identified the molecular pathways involved. Fisetin reduced brain injury, oxidative stress, and neuroinflammation, while promoting BDNF expression and reducing apoptosis and cognitive deficits. These effects may be attributed to the inhibition of NF-kappa B/NLRP3 inflammasome activation and the activation of antioxidant pathways.

BIOMEDICINES (2022)

Article Chemistry, Multidisciplinary

Engineered extracellular vesicles and their mimetics for cancer immunotherapy

Chunping Liu et al.

Summary: Extracellular vesicles (EVs) are membranous vesicles secreted by living cells, serving as intermediaries for intercellular communication and molecular transfer. Recent studies have shown that EVs can regulate tumor occurrence and development by transferring molecules and have broad application prospects in immunotherapy. The breakthrough of nanotechnology promotes the development and exploration of engineered EVs for immune-targeted therapy.

JOURNAL OF CONTROLLED RELEASE (2022)

Review Endocrinology & Metabolism

Unravelling the potential neuroprotective facets of erythropoietin for the treatment of Alzheimer's disease

Dapinder Kaur et al.

Summary: Recombinant DNA technology has produced erythropoietin (EPO), which has shown neuroprotective effects in the treatment of neurodegenerative diseases, particularly Alzheimer's disease (AD). AD is characterized by the accumulation of plaques and tangles, and currently lacks a successful treatment strategy. Various clinical studies have demonstrated the potential therapeutic benefits of EPO as a neuroprotective agent in the treatment of AD.

METABOLIC BRAIN DISEASE (2022)

Review Pharmacology & Pharmacy

An Overview of the Mechanisms of Marine Fungi-Derived Anti-Inflammatory and Anti-Tumor Agents and their Novel Role in Drug Targeting

Syed Shams ul Hassan et al.

Summary: Marine fungi are considered a treasure trove of ocean medicines due to their successful pharmacological effects and the potential of their secondary metabolites. While there is still much to be discovered about the biological actions of these compounds, research on fungi-derived bioactive molecules is crucial for the development of targeted drugs against specific diseases within the body.

CURRENT PHARMACEUTICAL DESIGN (2021)

Review Pharmacology & Pharmacy

Enhancing Therapeutic Efficacy of Donepezil by Combined Therapy: A Comprehensive Review

Xi Rong et al.

Summary: Combination therapy involving different therapeutic strategies often yields faster and more effective results compared to monotherapy in clinical practice. The acetylcholinesterase inhibitor donepezil, known for its role in Alzheimer's disease, has attracted attention for its neuroprotective, muscle relaxant, and sleep-inducing properties. Recent studies have shown promising results in managing various disorders, including Alzheimer's disease, through the combination of donepezil with other agents.

CURRENT PHARMACEUTICAL DESIGN (2021)

Review Pharmacology & Pharmacy

Fisetin, potential flavonoid with multifarious targets for treating neurological disorders: An updated review

Arun Reddy Ravula et al.

Summary: Fisetin, as a potential molecule for treating neurodegenerative diseases, is believed to positively impact neurobehavioral and cognitive abnormalities. It has shown various health benefits in clinical models of neurodegenerative diseases and is thought to have the potential to treat these diseases through multiple mechanisms.

EUROPEAN JOURNAL OF PHARMACOLOGY (2021)

Article Multidisciplinary Sciences

Damaged lung gas exchange function of discharged COVID-19 patients detected by hyperpolarized 129Xe MRI

Haidong Li et al.

Summary: The recovery process of COVID-19 patients remains unclear, with some experiencing ongoing respiratory issues. Xe-129 MRI analysis reveals higher ventilation defects and longer gas-blood exchange time in COVID-19 patients, indicating lung function impairment during recovery.

SCIENCE ADVANCES (2021)

Article Pharmacology & Pharmacy

Fisetin Rescues the Mice Brains Against D-Galactose-Induced Oxidative Stress, Neuroinflammation and Memory Impairment

Sareer Ahmad et al.

Summary: In this study, Fisetin was found to protect against d-galactose-induced oxidative stress, neuroinflammation, and memory impairment in mice by regulating antioxidant mechanisms, inhibiting inflammatory pathways, and preventing ROS accumulation. This suggests that Fisetin may be beneficial in addressing age-related neurological disorders.

FRONTIERS IN PHARMACOLOGY (2021)

Article Cell Biology

Homocysteine inhibits pro-insulin receptor cleavage and causes insulin resistance via protein cysteine-homocysteinylation

Xuan Zhang et al.

Summary: Elevated homocysteine levels are associated with insulin resistance, which is induced by homocysteinylation of the pro-insulin receptor. Homocysteine reacts with and modifies cysteine-825 of pro-IR in the ER, disrupting the original disulfide bond. This modification impairs the interaction between pro-IR and Furin protease in the Golgi apparatus, hindering cleavage of pro-IR and leading to insulin resistance in mice. Inhibiting homocysteinylation could potentially be a new target for drugs to prevent insulin resistance and increase insulin sensitivity.

CELL REPORTS (2021)

Article Biochemistry & Molecular Biology

Fisetin inhibits tau aggregation by interacting with the protein and preventing the formation of ll-strands

Shifeng Xiao et al.

Summary: Fisetin has shown potential in inhibiting tau protein aggregation and preventing the formation of tau aggregates in cells. It could be a candidate for further development as a potential preventive or therapeutic drug for Alzheimer's disease.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

Article Biochemistry & Molecular Biology

Flavonoid fisetin reverses impaired hippocampal synaptic plasticity and cognitive function by regulating the function of AMPARs in a male rat model of schizophrenia

Jin-Qiong Zhan et al.

Summary: The study shows that fisetin treatment can reverse deficits in hippocampal synaptic plasticity and memory in a male rat model of schizophrenia by restoring the phosphorylation and surface expression of AMPAR GluA1 subunit, indicating fisetin as a promising therapeutic candidate for schizophrenia-associated cognitive deficits.

JOURNAL OF NEUROCHEMISTRY (2021)

Article Biochemistry & Molecular Biology

Modulation of α-synuclein fibrillation by plant metabolites, daidzein, fisetin and scopoletin under physiological conditions

Ankita R. Rane et al.

Summary: The study investigated the effects of three plant metabolites, daidzein, fisetin and scopoletin, on the aggregation of alpha-synuclein, showing they have the ability to inhibit alpha-Syn fibrillation. Experimental results shed light on the inhibitory mechanisms of these compounds, providing important implications for identifying potent therapeutic molecules for PD and other synucleinopathies.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

Article Multidisciplinary Sciences

Low chorionic villous succinate accumulation associates with recurrent spontaneous abortion risk

Xiao-Hui Wang et al.

Summary: Abnormal metabolite levels in the villous tissues inhibit extravillous trophoblast function, leading to an increased risk of recurrent spontaneous abortion (RSA). Modulating succinate levels may serve as a potential intervention strategy for RSA.

NATURE COMMUNICATIONS (2021)

Article Nutrition & Dietetics

Fisetin Improved Rotenone-Induced Behavioral Deficits, Oxidative Changes, and Mitochondrial Dysfunctions in Rat Model of Parkinson's Disease

Kanakalatha Alikatte et al.

Summary: In this study, fisetin was found to improve motor function and reverse biochemical changes in the rotenone-induced rat model of Parkinson's disease. The effects of fisetin were dose-dependent and significantly enhanced rotenone-induced behavioral and biochemical changes.

JOURNAL OF DIETARY SUPPLEMENTS (2021)

Article Medicine, Research & Experimental

Attenuation of reserpine-induced fibromyalgia via ROS and serotonergic pathway modulation by fisetin, a plant flavonoid polyphenol

Xianli Yao et al.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2020)

Article Multidisciplinary Sciences

Hyperpolarized Xe NMR signal advancement by metal-organic framework entrapment in solution

Qingbin Zeng et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Review Health Care Sciences & Services

Molecular and Therapeutic Effects of Fisetin Flavonoid in Diseases

Ezgi Nur Sari et al.

JOURNAL OF BASIC AND CLINICAL HEALTH SCIENCES (2020)

Article Biochemistry & Molecular Biology

Nrf2-ARE Signaling Acts as Master Pathway for the Cellular Antioxidant Activity of Fisetin

Huihui Zhang et al.

MOLECULES (2019)

Review Biochemistry & Molecular Biology

The Potential of Flavonoids for the Treatment of Neurodegenerative Diseases

Pamela Maher

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Article Biochemistry & Molecular Biology

The plant flavonoid, fisetin alleviates cigarette smoke-induced oxidative stress, and inflammation in Wistar rat lungs

Tajamul Hussain et al.

JOURNAL OF FOOD BIOCHEMISTRY (2019)

Review Geriatrics & Gerontology

Flavonoids as Prospective Neuroprotectants and Their Therapeutic Propensity in Aging Associated Neurological Disorders

Muhammad Ayaz et al.

FRONTIERS IN AGING NEUROSCIENCE (2019)

Review Biochemistry & Molecular Biology

Animal Models for Parkinson's Disease Research: Trends in the 2000s

Kyohei Kin et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Article Public, Environmental & Occupational Health

The contribution of neurologic disorders to the national prevalence of depression and anxiety problems among children and adolescents

Daniel G. Whitney et al.

ANNALS OF EPIDEMIOLOGY (2019)

Review Chemistry, Multidisciplinary

New Perspectives for Fisetin

Grzegorz Grynkiewicz et al.

FRONTIERS IN CHEMISTRY (2019)

Article Geriatrics & Gerontology

Fisetin Reduces the Impact of Aging on Behavior and Physiology in the Rapidly Aging SAMP8 Mouse

Antonio Currais et al.

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2018)

Article Clinical Neurology

Fisetin Protects against Intracerebral Hemorrhage-Induced Neuroinflammation in Aged Mice

Cheng Chen et al.

CEREBROVASCULAR DISEASES (2018)

Article Agriculture, Multidisciplinary

Pharmacokinetics and Biliary Excretion of Fisetin in Rats

Miao-Chan Huang et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2018)

Article Pharmacology & Pharmacy

Oral administration of fisetin promotes the induction of hippocampal long-term potentiation in vivo

Wen-bin He et al.

JOURNAL OF PHARMACOLOGICAL SCIENCES (2018)

Article Biochemistry & Molecular Biology

Fisetin alleviates oxidative stress after traumatic brain injury via the Nrf2-ARE pathway

Li Zhang et al.

NEUROCHEMISTRY INTERNATIONAL (2018)

Article Medicine, General & Internal

Fisetin is a senotherapeutic that extends health and lifespan

Matthew J. Yousefzadeh et al.

EBIOMEDICINE (2018)

Article Biochemistry & Molecular Biology

Fisetin provides antidepressant effects by activating the tropomyosin receptor kinase B signal pathway in mice

Yamin Wang et al.

JOURNAL OF NEUROCHEMISTRY (2017)

Review Neurosciences

Non-motor features of Parkinson disease

Anthony H. V. Schapira et al.

NATURE REVIEWS NEUROSCIENCE (2017)

Review Cell Biology

Antidepressant Flavonoids and Their Relationship with Oxidative Stress

Lucian Hritcu et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2017)

Review Cell Biology

Oxidative Stress: Harms and Benefits for Human Health

Gabriele Pizzino et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2017)

Review Food Science & Technology

Antioxidant properties of the flavonoid fisetin: An updated review of in vivo and in vitro studies

Alireza Farsad Naeimi et al.

TRENDS IN FOOD SCIENCE & TECHNOLOGY (2017)

Article Pharmacology & Pharmacy

Anti-inflammatory effects of kaempferol, myricetin, fisetin and ibuprofen in neonatal rats

Peng Guo et al.

TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH (2017)

Article Pharmacology & Pharmacy

Effects of fisetin on hyperhomocysteinemia-induced experimental endothelial dysfunction and vascular dementia

Boyina Hemanth Kumar et al.

CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY (2017)

Review Pharmacology & Pharmacy

Oxidative Stress and the Central Nervous System

Samina Salim

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2017)

Article Biochemistry & Molecular Biology

Energy defects in Huntington's disease: Why in vivo evidence matters

Geraldine Liot et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2017)

Review Neurosciences

Oxidative stress in multiple sclerosis: Central and peripheral mode of action

Kim Ohl et al.

EXPERIMENTAL NEUROLOGY (2016)

Review Medicine, Research & Experimental

Occupational and environmental exposure to pesticides and cytokine pathways in chronic diseases

Silvia Gangemi et al.

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2016)

Article Biochemical Research Methods

Identification of absolute conversion to geraldol from fisetin and pharmacokinetics in mouse

Jun Hyeon Jo et al.

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES (2016)

Article Materials Science, Biomaterials

Nanoencapsulation of dietary flavonoid fisetin: Formulation and in vitro antioxidant and α-glucosidase inhibition activities

Mario Sechi et al.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2016)

Article Endocrinology & Metabolism

The effects of fisetin on lipopolysaccharide-induced depressive-like behavior in mice

Xuefeng Yu et al.

METABOLIC BRAIN DISEASE (2016)

Review Multidisciplinary Sciences

Ageing, neurodegeneration and brain rejuvenation

Tony Wyss-Coray

NATURE (2016)

Review Neurosciences

Understanding Dopaminergic Cell Death Pathways in Parkinson Disease

Patrick P. Michel et al.

NEURON (2016)

Article Cell Biology

Comparative Analysis of the Interaction between Different Flavonoids and PDIA3

Flavia Giamogante et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2016)

Review Oncology

Exploring the molecular targets of dietary flavonoid fisetin in cancer

Deeba N. Syed et al.

SEMINARS IN CANCER BIOLOGY (2016)

Article Pharmacology & Pharmacy

Fisetin Protects DNA Against Oxidative Damage and Its Possible Mechanism

Tingting Wang et al.

ADVANCED PHARMACEUTICAL BULLETIN (2016)

Article Biochemistry & Molecular Biology

Fisetin Suppresses Macrophage-Mediated Inflammatory Responses by Blockade of Src and Syk

Jun Ho Kim et al.

BIOMOLECULES & THERAPEUTICS (2015)

Article Biochemistry & Molecular Biology

Flavonoids and Dementia: An Update

I. E. Orhan et al.

CURRENT MEDICINAL CHEMISTRY (2015)

Review Biochemistry & Molecular Biology

Understanding the susceptibility of dopamine neurons to mitochondrial stressors in Parkinson's disease

Dominik Haddad et al.

FEBS LETTERS (2015)

Article Biochemistry & Molecular Biology

Beyond the redox imbalance: Oxidative stress contributes to an impaired GLUT3 modulation in Huntington's disease

Adriana Covarrubias-Pinto et al.

FREE RADICAL BIOLOGY AND MEDICINE (2015)

Article Biochemistry & Molecular Biology

Dietary flavonoid fisetin regulates aluminium chloride-induced neuronal apoptosis in cortex and hippocampus of mice brain

Dharmalingam Prakash et al.

JOURNAL OF NUTRITIONAL BIOCHEMISTRY (2015)

Article Medicine, General & Internal

Parkinson's disease

Lorraine V. Kalia et al.

LANCET (2015)

Article Biochemistry & Molecular Biology

Characterization of the Neuroprotective Potential of Derivatives of the Iron Chelating Drug Deferiprone

Pamela Maher et al.

NEUROCHEMICAL RESEARCH (2015)

Article Biochemistry & Molecular Biology

Cell and brain tissue imaging of the flavonoid fisetin using label-free two-photon microscopy

Tatiana B. Krasieva et al.

NEUROCHEMISTRY INTERNATIONAL (2015)

Review Pharmacology & Pharmacy

A review on Alzheimer's disease pathophysiology and its management: an update

Anil Kumar et al.

PHARMACOLOGICAL REPORTS (2015)

Review Chemistry, Multidisciplinary

Properties and applications of flavonoid metal complexes

Maria M. Kasprzak et al.

RSC ADVANCES (2015)

Article Pharmacology & Pharmacy

Effects of fisetin on oxaliplatin-induced neuropathic pain in mice

Hong Liu et al.

BANGLADESH JOURNAL OF PHARMACOLOGY (2015)

Article Biochemistry & Molecular Biology

Akt-independent GSK3 inactivation downstream of PI3K signaling regulates mammalian axon regeneration

Bo-Yin Zhang et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2014)

Review Pharmacology & Pharmacy

Alzheimer disease: Epidemiology, diagnostic criteria, risk factors and biomarkers

Christiane Reitz et al.

BIOCHEMICAL PHARMACOLOGY (2014)

Article Chemistry, Multidisciplinary

Improving solubility of fisetin by cocrystallization

Michal Sowa et al.

CRYSTENGCOMM (2014)

Review Genetics & Heredity

Flavonoids in modulation of cell survival signalling pathways

Mohammad Lukman Mansuri et al.

GENES AND NUTRITION (2014)

Article Biochemistry & Molecular Biology

Regulatory Effects of Fisetin on Microglial Activation

Jing-Yuan Chuang et al.

MOLECULES (2014)

Review Anatomy & Morphology

Molecular determinants of selective dopaminergic vulnerability in Parkinson's disease: an update

Lars Brichta et al.

FRONTIERS IN NEUROANATOMY (2014)

Review Neurosciences

GSK-3β, a pivotal kinase in Alzheimer disease

Maria Llorens-Martin et al.

FRONTIERS IN MOLECULAR NEUROSCIENCE (2014)

Article Mathematical & Computational Biology

Molecular docking of fisetin with AD associated AChE, ABAD and BACE1 proteins

Raju Dash et al.

BIOINFORMATION (2014)

Article Physiology

Low PO2 conditions induce reactive oxygen species formation during contractions in single skeletal muscle fibers

Li Zuo et al.

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY (2013)

Review Biochemistry & Molecular Biology

Fisetin: A Dietary Antioxidant for Health Promotion

Naghma Khan et al.

ANTIOXIDANTS & REDOX SIGNALING (2013)

Review Biochemistry & Molecular Biology

Redox Regulation of T-Cell Function: From Molecular Mechanisms to Significance in Human Health and Disease

Pravin Kesarwani et al.

ANTIOXIDANTS & REDOX SIGNALING (2013)

Review Biochemistry & Molecular Biology

Functional Consequences of Age-Dependent Changes in Glutathione Status in the Brain

Antonio Currais et al.

ANTIOXIDANTS & REDOX SIGNALING (2013)

Article Clinical Neurology

Disease-specific molecular events in cortical multiple sclerosis lesions

Marie Therese Fischer et al.

Review Clinical Neurology

Is SOD1 loss of function involved in amyotrophic lateral sclerosis?

Rachele A. Saccon et al.

Article Pharmacology & Pharmacy

Bioavailability of bioactive food compounds: a challenging journey to bioefficacy

Maarit J. Rein et al.

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY (2013)

Review Cell Biology

Complexity of dopamine metabolism

Johannes Meiser et al.

CELL COMMUNICATION AND SIGNALING (2013)

Review Environmental Sciences

Environmental factors and unhealthy lifestyle influence oxidative stress in humans-an overview

G. Smilin Bell Aseervatham et al.

ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH (2013)

Review Biochemistry & Molecular Biology

Clinical perspective on oxidative stress in sporadic amyotrophic lateral sclerosis

Emanuele D'Amico et al.

FREE RADICAL BIOLOGY AND MEDICINE (2013)

Review Neurosciences

Emerging roles of Nrf2 and phase II antioxidant enzymes in neuroprotection

Meijuan Zhang et al.

PROGRESS IN NEUROBIOLOGY (2013)

Review Neurosciences

The Role of Oxidative Stress in Parkinson's Disease

Vera Dias et al.

JOURNAL OF PARKINSONS DISEASE (2013)

Article Endocrinology & Metabolism

Fisetin averts oxidative stress in pancreatic tissues of streptozotocin-induced diabetic rats

Gopalan Sriram Prasath et al.

ENDOCRINE (2013)

Article Behavioral Sciences

The antidepressant-like effect of fisetin involves the serotonergic and noradrenergic system

Linlin Zhen et al.

BEHAVIOURAL BRAIN RESEARCH (2012)

Article Biochemistry & Molecular Biology

Dithiol-based Compounds Maintain Expression of Antioxidant Protein Peroxiredoxin 1 That Counteracts Toxicity of Mutant Huntingtin

Andrea Pitts et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2012)

Article Biochemistry & Molecular Biology

Post-aggregation Oxidation of Mutant Huntingtin Controls the Interactions between Aggregates

Yasushi Mitomi et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2012)

Review Chemistry, Medicinal

Small Molecule Modulators of Keap1-Nrf2-ARE Pathway as Potential Preventive and Therapeutic Agents

Sadagopan Magesh et al.

MEDICINAL RESEARCH REVIEWS (2012)

Article Neurosciences

3,3′,4′,5,5′-Pentahydroxyflavone is a potent inhibitor of amyloid β fibril formation

Hiroko Ushikubo et al.

NEUROSCIENCE LETTERS (2012)

Article Neurosciences

The Neuroprotective Effect of Fisetin in the MPTP Model of Parkinson's Disease

Mital Y. Patel et al.

JOURNAL OF PARKINSONS DISEASE (2012)

Review Toxicology

The cytoprotective role of the Keap1-Nrf2 pathway

Liam Baird et al.

ARCHIVES OF TOXICOLOGY (2011)

Article Pharmacology & Pharmacy

Fisetin disposition and metabolism in mice: Identification of geraldol as an active metabolite

Yasmine S. Touil et al.

BIOCHEMICAL PHARMACOLOGY (2011)

Article Clinical Neurology

Oxidative damage in multiple sclerosis lesions

Lukas Haider et al.

Article Endocrinology & Metabolism

The role of the antioxidant and longevity-promoting Nrf2 pathway in metabolic regulation

Gerasimos P. Sykiotis et al.

CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE (2011)

Article Biochemistry & Molecular Biology

Fisetin Induces Nrf2-Mediated HO-1 Expression Through PKC-δ and p38 in Human Umbilical Vein Endothelial Cells

Seung Eun Lee et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2011)

Article Cell Biology

Synaptic Vesicle Exocytosis

Thomas C. Suedhof et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2011)

Article Biochemistry & Molecular Biology

Oxidative damage in Parkinson disease: Measurement using accurate biomarkers

Raymond C. S. Seet et al.

FREE RADICAL BIOLOGY AND MEDICINE (2010)

Article Neurosciences

Reactive Oxygen Species: Stuck in the Middle of Neurodegeneration

David A. Patten et al.

JOURNAL OF ALZHEIMERS DISEASE (2010)

Review Neurosciences

Oxidative stress in Alzheimer disease: A possibility for prevention

David J. Bonda et al.

NEUROPHARMACOLOGY (2010)

Review Geriatrics & Gerontology

Atypical pathways of NF-κB activation and aging

Andres Kriete et al.

EXPERIMENTAL GERONTOLOGY (2009)

Article Neurosciences

An Intrinsic Neuronal Oscillator Underlies Dopaminergic Neuron Bursting

Christopher A. Deister et al.

JOURNAL OF NEUROSCIENCE (2009)

Article Multidisciplinary Sciences

Disruption of NMDAR-dependent burst firing by dopamine neurons provides selective assessment of phasic dopamine-dependent behavior

Larry S. Zweifel et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Review Pathology

The aging brain

Bruce A. Yankner et al.

ANNUAL REVIEW OF PATHOLOGY-MECHANISMS OF DISEASE (2008)

Article Biochemistry & Molecular Biology

The flavonoid fisetin promotes nerve cell survival from trophic factor withdrawal by enhancement of proteasome activity

Pamela Maher

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2008)

Review Medicine, Research & Experimental

Excitotoxic neuronal death and the pathogenesis of Huntington's disease

Ana Maria Estrada Sanchez et al.

ARCHIVES OF MEDICAL RESEARCH (2008)

Article Clinical Neurology

Cholinergic system during the progression of Alzheimer’s disease: therapeutic implications

Elliott J Mufson et al.

Expert Review of Neurotherapeutics (2008)

Article Biochemistry & Molecular Biology

Proteomic and oxidative stress analysis in human brain samples of Huntington disease

M. Alba Sorolla et al.

FREE RADICAL BIOLOGY AND MEDICINE (2008)

Review Biochemistry & Molecular Biology

Nrf2-induced antioxidant Protection: A Promising target to counteract ROS-mediated damage in neurodegenerative disease?

Helga E. de Vries et al.

FREE RADICAL BIOLOGY AND MEDICINE (2008)

Article Biochemistry & Molecular Biology

Amyloid beta peptide and NMDA induce ROS from NADPH oxidase and AA release from cytosolic phospholipase A2 in cortical neurons

Phullara B. Shelat et al.

JOURNAL OF NEUROCHEMISTRY (2008)

Review Neurosciences

Mutant huntingtin and mitochondrial dysfunction

Ella Bossy-Wetzel et al.

TRENDS IN NEUROSCIENCES (2008)

Article Biochemistry & Molecular Biology

Mitochondria, oxidative stress and cell death

Martin Ott et al.

APOPTOSIS (2007)

Article Agriculture, Multidisciplinary

Distinctive antioxidant and antiinflammatory effects of flavonols

Lisu Wang et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2006)

Review Multidisciplinary Sciences

A century of Alzheimer's disease

Michel Goedert et al.

SCIENCE (2006)

Article Multidisciplinary Sciences

Flavonoid fisetin promotes ERK-dependent long-term potentiation and enhances memory

Pamela Maher et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

Review Multidisciplinary Sciences

Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases

Michael T. Lin et al.

NATURE (2006)

Article Biochemistry & Molecular Biology

A comparison of the neurotrophic activities of the flavonoid fisetin and some of its derivatives

Pamela Maher

FREE RADICAL RESEARCH (2006)

Article Chemistry, Physical

Study of the complexation of fisetin with cyclodextrins

Mariana R. Guzzo et al.

JOURNAL OF PHYSICAL CHEMISTRY A (2006)

Review Neurosciences

Ageing and neuronal vulnerability

MP Mattson et al.

NATURE REVIEWS NEUROSCIENCE (2006)

Review Genetics & Heredity

Role of mitochondrial DNA in toxic responses to oxidative stress

B Van Houten et al.

DNA REPAIR (2006)

Article Ophthalmology

Flavonoids protect retinal ganglion cells from oxidative stress-induced death

P Maher et al.

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2005)

Review Cell Biology

The cell cycle in Alzheimer disease: A unique target for neuropharmacology

KM Webber et al.

MECHANISMS OF AGEING AND DEVELOPMENT (2005)

Article Clinical Neurology

Evidence of oxidative stress in the neocortex in incidental Lewy body disease

E Dalfó et al.

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2005)

Review Biochemistry & Molecular Biology

Dietary chemopreventive compounds and ARE/EpRE signaling

C Chen et al.

FREE RADICAL BIOLOGY AND MEDICINE (2004)

Article Multidisciplinary Sciences

NADPH oxidase mediates oxidative stress in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease

DC Wu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)

Article Clinical Neurology

Colocalization of tau and alpha-synuclein epitopes in Lewy bodies

T Ishizawa et al.

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2003)

Article Chemistry, Medicinal

Structure-activity study on the quinone/quinone methide chemistry of flavonoids

HM Awad et al.

CHEMICAL RESEARCH IN TOXICOLOGY (2001)

Article Biochemistry & Molecular Biology

Decreased expression of striatal signaling genes in a mouse model of Huntington's disease

R Luthi-Carter et al.

HUMAN MOLECULAR GENETICS (2000)