Acute, chronic, and genotoxic studies on the protopine total alkaloids of the Macleaya cordata (willd.) R. Br. in rodents

Article Plant Sciences

Placental Passage of Protopine in an Ex Vivo Human Perfusion System

Deborah Spiess et al.

Summary: The placental passage of protopine was examined using a human ex vivo placental perfusion model. The study demonstrated that protopine can cross the placental barrier without affecting the viability and functionality of the placenta.

PLANTA MEDICA (2023)

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Article Plant Sciences

Protopine promotes the proteasomal degradation of pathological tau in Alzheimer's disease models via HDAC6 inhibition

Sravan Gopalkrishnashetty Sreenivasmurthy et al.

Summary: The study found that protopine (PRO) reduces abnormal tau protein in the brains of Alzheimer's disease (AD) patients, improving memory and cognition. The research confirmed the pharmacokinetics of PRO and its mechanism of action through experiments.

PHYTOMEDICINE (2022)

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Article Pharmacology & Pharmacy

Acute Oral, Subacute, and Developmental Toxicity Profiling of Naphthalene 2-Yl, 2-Chloro, 5-Nitrobenzoate: Assessment Based on Stress Response, Toxicity, and Adverse Outcome Pathways

Fareeha Anwar et al.

Summary: This study adopts a new approach introduced by the U.S. National Research Council (NRC) that moves from traditional animal studies to cellular pathways. The results show that SF5 did not reach abrupt and high levels of toxicity in organs and biochemical parameters, making it safe for further studies.

FRONTIERS IN PHARMACOLOGY (2022)

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Review Medicine, General & Internal

Acute kidney injury associated with non-steroidal anti-inflammatory drugs

Nattawat Klomjit et al.

Summary: Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly prescribed drugs that inhibit COX enzyme, affecting prostaglandin production and causing various renal complications. AKI from NSAIDs is usually reversible after discontinuation, emphasizing the importance of avoiding NSAIDs in high-risk patients.

EUROPEAN JOURNAL OF INTERNAL MEDICINE (2022)

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Article Medicine, Legal

Safety assessment of MPTA: An oral acute and 90-day sub-chronic toxicity study in Sprague-Dawley rats

Zhen Dong et al.

Summary: The acute and subchronic toxicity studies of MPTA on SD rats revealed that MPTA has a low toxicity profile with no significant adverse effects observed in both short-term and long-term oral administration. The NOEAL of MPTA was established at 96.40 mg/kg/d, indicating a high level of safety for oral consumption.

REGULATORY TOXICOLOGY AND PHARMACOLOGY (2022)

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Article Physiology

Maternal Prepregnancy 5-Hydroxytryptamine Exposure Affects the Early Development of the Fetus

Yu Han et al.

Summary: Maternal exposure to 5-HT before pregnancy may affect fetal development, leading to reduced hormonal secretion and placental inflammation.

FRONTIERS IN PHYSIOLOGY (2022)

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Article Pharmacology & Pharmacy

Advanced in Vitro Safety Assessment of Herbal Medicines for the Treatment of Non-Psychotic Mental Disorders in Pregnancy

Deborah Spiess et al.

Summary: This study examines the safety of using herbal medicines, such as St. John's wort, California poppy, valerian, lavender, and hops, in pregnant women with non-psychotic mental disorders. The results suggest that extracts from these plants are likely to be safe at usual clinical doses, but high plasma concentrations of certain phytochemicals should be monitored for potential effects on the fetus.

FRONTIERS IN PHARMACOLOGY (2022)

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Article Physiology

Effects of Dietary Bopu Powder Supplementation on Serum Antioxidant Capacity, Egg Quality, and Intestinal Microbiota of Laying Hens

Hua Liu et al.

Summary: The addition of dietary Bopu powder improved the antioxidant capacity, serum biochemical indices, egg quality, and intestinal microbiota of laying hens. The optimal dosage for Bopu powder additive in laying hen diet was found to be 25-50 mg/kg. The supplementation of Bopu powder increased the abundance of beneficial bacteria in the gut.

FRONTIERS IN PHYSIOLOGY (2022)

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Article Veterinary Sciences

Exploring the Anti-inflammatory Effects of Protopine Total Alkaloids of Macleaya Cordata (Willd.) R. Br.

Zhen Dong et al.

Summary: This study evaluated the anti-inflammatory activity of protopine total alkaloids (MPTAs) in Macleaya cordata (Willd.) R. Br. The results showed that MPTA exhibited significant anti-inflammatory effects in vivo tests in rats and mice. In addition, the potential mechanisms of MPTA's anti-inflammatory effects were explored through network pharmacology and molecular docking methods.

FRONTIERS IN VETERINARY SCIENCE (2022)

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Article Environmental Sciences

How to analyse and account for interactions in mixture toxicity with toxicokinetic-toxicodynamic models

Sylvain Bart et al.

Summary: The assessment of chemical mixture toxicity is a major challenge in ecotoxicology. In this study, a new approach using toxicokinetic-toxicodynamic modeling was proposed, which accurately simulated synergistic and antagonistic effects of different mixtures on various species. This model can identify interactions throughout the exposure time and provide predictions for untested exposure scenarios.

SCIENCE OF THE TOTAL ENVIRONMENT (2022)

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Article Obstetrics & Gynecology

Aspirin use during pregnancy and the risk of bleeding complications: a Swedish population-based cohort study

Roxanne Hastie et al.

Summary: The study found that the use of aspirin during pregnancy is associated with an increased risk of intrapartum bleeding, postpartum bleeding, and neonatal intracranial hemorrhage, without increasing the risk of antepartum bleeding. When recommending aspirin during pregnancy, the potential benefits need to be weighed against the risks of intrapartum, postpartum bleeding, and neonatal intracranial hemorrhage.

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY (2021)

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Article Plant Sciences

Diverse isoquinolines with anti-inflammatory and analgesic bioactivities from Hypecoum erectum

Hai-Lian Yuan et al.

Summary: Ethnopharmacological studies have shown that Hypecoum erectum is used in traditional medicine for treating inflammation, fever, and pain, but its chemical constituents and effects have not been fully explored. This study aimed to validate its traditional use by investigating its anti-inflammatory and analgesic effects, and identifying potential bioactive compounds. The findings demonstrated the diversity and novelty of isoquinoline alkaloids in H. erectum, with four major constituents showing significant anti-inflammatory and analgesic effects, supporting its traditional medicinal application.

JOURNAL OF ETHNOPHARMACOLOGY (2021)

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Article Plant Sciences

Analgesic effect of the main components of Corydalis yanhusuo (yanhusuo in Chinese) is caused by inhibition of voltage gated sodium channels

Yijia Xu et al.

Summary: Pain can lead to abnormal changes in physiology and psychology, and drug therapy is the most basic method for pain relief. Traditional Chinese medicines, such as Corydalis yanhusuo, have been developed into new painkillers. This study aims to determine the analgesic effect and potential targets of monomers derived from Corydalis yanhusuo.

JOURNAL OF ETHNOPHARMACOLOGY (2021)

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Article Plant Sciences

Discovery of tetrahydropalmatine and protopine regulate the expression of dopamine receptor D2 to alleviate migraine from Yuanhu Zhitong formula

Xiaohui Zhang et al.

Summary: Migraine is a common disease with negative impacts on patients' quality of life. Traditional Chinese medicine prescription YHZTF contains compounds like tetrahydropalmatine and protopine, which target dopamine receptors and alleviate migraine symptoms in an animal model by regulating DRD2 expression. This study sheds light on potential natural product-based therapeutic strategies for migraine.

PHYTOMEDICINE (2021)

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Article Veterinary Sciences

Potential Toxicity Evaluation of Protopine in Macleaya cordata (Willd.) R. Br.-A Bioactivity Guided Approach

Wanjun Hu et al.

Summary: The primary component of Macleaya cordata, protopine, was found to be toxic, causing hemorrhage in the respiratory system, lung congestion, and hemorrhage and edema in several parenchymatous organs. Phytopreparations containing protopine may pose a serious health threat to humans and animals.

FRONTIERS IN VETERINARY SCIENCE (2021)

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Article Pharmacology & Pharmacy

Toxicity Evaluation of the Naphthalen-2-yl 3,5-Dinitrobenzoate: A Drug Candidate for Alzheimer Disease

Fareeha Anwar et al.

Summary: The study demonstrated that SF1 can induce toxic effects in rats at certain doses, affecting various biochemical markers and reproductive functions. However, no fetal abnormalities were observed at the doses given. Therefore, SF1 may have an impact on liver function and the immune system at doses below the LD50, but it can be safely used during pregnancy.

FRONTIERS IN PHARMACOLOGY (2021)

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Article Chemistry, Multidisciplinary

Toxicological Screening of 4-Phenyl-3,4-dihydrobenzo[h]quinolin-2(1H)-one: A New Potential Candidate for Alzheimer's Treatment

Fareeha Anwar et al.

Summary: The toxicity studies on a new drug SF3, including acute oral, subacute, and teratogenicity studies, showed low toxicity levels and minimal impact on organ and biochemical parameters, indicating its safety as a potential drug candidate.

ACS OMEGA (2021)

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Article Medicine, Research & Experimental

Neuroprotective effects of allocryptopine-rich alkaloid extracts against oxidative stress-induced neuronal damage

Serap Nigdelioglu Dolanbay et al.

Summary: The study investigated the anti-oxidative, anti-apoptotic, and cell cycle regulatory mechanisms of alkaloid extracts from Glaucium corniculatum against H2O2-induced neuronal damage. Results showed that allocryptopine in the extracts suppressed oxidative stress-induced neuronal apoptosis by regulating multiple mechanisms, offering a potential strategy for exploring novel drugs for neuroprotection and cognitive improvement.

BIOMEDICINE & PHARMACOTHERAPY (2021)

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Article Biochemical Research Methods