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Bin Zeng et al.
PHYTOTHERAPY RESEARCH (2022)
Acute and Subacute Toxicity Assessment of Andrographolide-2-hydroxypropyl-β-cyclodextrin Complex via Oral and Inhalation Route of Administration in Sprague-Dawley Rats
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Andrographolide suppresses osteoarthritis progression by regulating circ_Rapgef1/miR-383-3p/NLRP3 signaling axis
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TRANSPLANT IMMUNOLOGY (2022)
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Andrographolide suppresses NLRP3 inflammasome activation in microglia through induction of parkin-mediated mitophagy in in-vitro and in-vivo models of Parkinson disease
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Synthesis, extracorporeal nephrotoxicity, and 3D-QSAR of andrographolide derivatives
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CHEMICAL BIOLOGY & DRUG DESIGN (2021)
Andrographolide attenuates inflammatory response induced by LPS via activating Nrf2 signaling pathway in bovine endometrial epithelial cells
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RESEARCH IN VETERINARY SCIENCE (2021)
Andrographolide inhibits IL-1β release in bone marrow-derived macrophages and monocyte infiltration in mouse knee joints induced by monosodium urate
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TOXICOLOGY AND APPLIED PHARMACOLOGY (2021)
Contraceptive potential of Andrographis paniculata is via androgen suppression and not induction of oxidative stress in male Wistar rats
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TISSUE & CELL (2021)
Anti-SARS-CoV-2 Activity of Andrographis paniculata Extract and Its Major Component Andrographolide in Human Lung Epithelial Cells and Cytotoxicity Evaluation in Major Organ Cell Representatives
Khanit Sa-ngiamsuntorn et al.
JOURNAL OF NATURAL PRODUCTS (2021)
Inhibition of Inducible Nitric Oxide Synthase (iNOS) by Andrographolide and In Vitro Evaluation of Its Antiproliferative and Proapoptotic Effects on Cervical Cancer
Akbar Pasha et al.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2021)
Efficacy and safety of Xiyanping injection in the treatment of COVID-19: A multicenter, prospective, open-label and randomized controlled trial
Xin-Yi Zhang et al.
PHYTOTHERAPY RESEARCH (2021)
Andrographolide Inhibition of Th17-Regulated Cytokines and JAK1/STAT3 Signaling in OVA-Stimulated Asthma in Mice
Qian Yu et al.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2021)
Andrographolide improves PCP-induced schizophrenia-like behaviors through blocking interaction between NRF2 and KEAP1
Xiying Wang et al.
JOURNAL OF PHARMACOLOGICAL SCIENCES (2021)
A Computational Approach Identified Andrographolide as a Potential Drug for Suppressing COVID-19-Induced Cytokine Storm
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FRONTIERS IN IMMUNOLOGY (2021)
Protective effect of andrographolide against STZ induced Alzheimer's disease in experimental rats: possible neuromodulation and Aβ(1-42) analysis
Royal Patel et al.
INFLAMMOPHARMACOLOGY (2021)
Andrographolide attenuates synovial inflammation of osteoarthritis by interacting with tumor necrosis factor receptor 2 trafficking in a rat model
Rongliang Wang et al.
JOURNAL OF ORTHOPAEDIC TRANSLATION (2021)
Andrographolide ameliorates oxidative stress, inflammation and histological outcome in complete Freund's adjuvant-induced arthritis
Shasha Luo et al.
CHEMICO-BIOLOGICAL INTERACTIONS (2020)
Protective Effect of Andrographolide on Alleviating Chronic Alcoholic Liver Disease in Mice by Inhibiting Nuclear Factor Kappa B and Tumor Necrosis Factor Alpha Activation
Yuan Song et al.
JOURNAL OF MEDICINAL FOOD (2020)
Improvement of Oxazolone-Induced Ulcerative Colitis in Rats Using Andrographolide
Liuhong Zhang et al.
MOLECULES (2020)
A Diterpenoid, 14-Deoxy-11, 12-Didehydroandrographolide, in Andrographis paniculata Reduces Steatohepatitis and Liver Injury in Mice Fed a High-Fat and High-Cholesterol Diet
Yun-Ta Liu et al.
NUTRIENTS (2020)
Efficacy of andrographolide in not active progressive multiple sclerosis: a prospective exploratory double-blind, parallel-group, randomized, placebo-controlled trial
Ethel Ciampi et al.
BMC NEUROLOGY (2020)
Restoration of HDAC2 and Nrf2 by andrographolide overcomes corticosteroid resistance in chronic obstructive pulmonary disease
Wupeng Liao et al.
BRITISH JOURNAL OF PHARMACOLOGY (2020)
Andrographolide attenuates oxidative stress injury in cigarette smoke extract exposed macrophages through inhibiting SIRT1/ERK signaling
Xin-fang Zhang et al.
INTERNATIONAL IMMUNOPHARMACOLOGY (2020)
Andrographolide mitigates cartilage damage via miR-27-3p-modulated matrix metalloproteinase13 repression
Shaojian Chen et al.
JOURNAL OF GENE MEDICINE (2020)
Andrographolide sulfonate ameliorates chronic colitis induced by TNBS in mice via decreasing inflammation and fibrosis
Jianhua Gao et al.
INTERNATIONAL IMMUNOPHARMACOLOGY (2020)
Andrographolide protects against endothelial dysfunction and inflammatory response in rats with coronary heart disease by regulating PPAR and NF-κB signaling pathways
Jia Shu et al.
ANNALS OF PALLIATIVE MEDICINE (2020)
Andrographolide and its fluorescent derivative inhibit the main proteases of 2019-nCoV and SARS-CoV through covalent linkage
Tzu-Hau Shi et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2020)
Andrographolide attenuates complete freund's adjuvant induced arthritis via suppression of inflammatory mediators and pro-inflammatory cytokines
Swati Gupta et al.
JOURNAL OF ETHNOPHARMACOLOGY (2020)
Andrographolide modulates OPG/RANKL axis to promote osteoblastic differentiation in MC3T3-E1 cells and protects bone loss during estrogen deficiency in rats
Duangrat Tantikanlayaporn et al.
BIOMEDICINE & PHARMACOTHERAPY (2020)
Andrographolide derivative ameliorates dextran sulfate sodium-induced experimental colitis in mice
Bao-Jian Guo et al.
BIOCHEMICAL PHARMACOLOGY (2019)
Synthesis of andrographolide analogues and their neuroprotection and neurite outgrowth-promoting activities
Yuanzhen Xu et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2019)
Andrographolide enhances hippocampal BDNF signaling and suppresses neuronal apoptosis, astroglial activation, neuroinflammation, and spatial memory deficits in a rat model of chronic cerebral hypoperfusion
Da-Peng Wang et al.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY (2019)
Neuroprotective effects of andrographolide derivative CX-10 in transient focal ischemia in rat: Involvement of Nrf2/AE and TLR/NF-κB signaling
Ming-Yan Yang et al.
PHARMACOLOGICAL RESEARCH (2019)
Andrographolide antagonizes the cigarette smoke-induced epithelial-mesenchymal transition and pulmonary dysfunction through anti-inflammatory inhibiting HOTAIR
Haibo Xia et al.
TOXICOLOGY (2019)
A review for the neuroprotective effects of andrographolide in the central nervous system
Jiashu Lu et al.
BIOMEDICINE & PHARMACOTHERAPY (2019)
Andrographolide triggers autophagy-mediated inflammation inhibition and attenuates chronic unpredictable mild stress (CUMS)-induced depressive-like behavior in mice
Ji Geng et al.
TOXICOLOGY AND APPLIED PHARMACOLOGY (2019)
Proinflammatory cytokines and lipopolysaccharides up regulate MMP-3 and MMP-13 production in Asian elephant (Elephas maximus) chondrocytes: attenuation by anti-arthritic agents
Nutnicha Sirikaew et al.
BMC VETERINARY RESEARCH (2019)
Andrographolide Ameliorates Rheumatoid Arthritis by Regulating the Apoptosis-NETosis Balance of Neutrophils
Xiaohong Li et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)
Andrographolide Derivative AL-1 Ameliorates Dextran Sodium Sulfate-Induced Murine Colitis by Inhibiting NF-κB and MAPK Signaling Pathways
Mei Jing et al.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2019)
Andrographolide inhibits inflammatory responses in LPS-stimulated macrophages and murine acute colitis through activating AMPK
Nami Kim et al.
BIOCHEMICAL PHARMACOLOGY (2019)
Andrographolide prevents human nucleus pulposus cells against degeneration by inhibiting the NF-κB pathway
Jianwei Liu et al.
JOURNAL OF CELLULAR PHYSIOLOGY (2019)
Inhibition of AIM2 inflammasome-mediated pyroptosis by Andrographolide contributes to amelioration of radiation-induced lung inflammation and fibrosis
Jian Gao et al.
CELL DEATH & DISEASE (2019)
Beneficial effects of andrographolide in a rat model of autoimmune myocarditis and its effects on PI3K/Akt pathway
Qi Zhang et al.
KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY (2019)
Evaluation of the effect of andrographolide and methotrexate combined therapy in complete Freund's adjuvant induced arthritis with reduced hepatotoxicity
Fenfen Li et al.
BIOMEDICINE & PHARMACOTHERAPY (2018)
Andrographolide Ameliorates Atherosclerosis by Suppressing Pro-Inflammation and ROS Generation-Mediated Foam Cell Formation
Teng Wu et al.
INFLAMMATION (2018)
Andrographolide derivative CX-10 ameliorates dextran sulphate sodium-induced ulcerative colitis in mice: Involvement of NF-κB and MAPK signalling pathways
Zhenfang Gao et al.
INTERNATIONAL IMMUNOPHARMACOLOGY (2018)
Andrographolide ameliorates silica induced pulmonary fibrosis
Sachin Karkale et al.
INTERNATIONAL IMMUNOPHARMACOLOGY (2018)
Inhibition of the hepatic Nlrp3 protects dopaminergic neurons via attenuating systemic inflammation in a MPTP/p mouse model of Parkinson's disease
Chen Qiao et al.
JOURNAL OF NEUROINFLAMMATION (2018)
Andrographolide affects Th1/Th2/Th17 responses of peripheral blood mononuclear cells from ulcerative colitis patients
Qin Zhu et al.
MOLECULAR MEDICINE REPORTS (2018)
Aortic plaque-targeted andrographolide delivery with oxidation-sensitive micelle effectively treats atherosclerosis via simultaneous ROS capture and anti-inflammation
Teng Wu et al.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2018)
Andrographolide Ameliorates Liver Fibrosis in Mice: Involvement of TLR4/NF-κB and TGF-β1/Smad2 Signaling Pathways
Liteng Lin et al.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2018)
Andrographolide relieved pathological pain generated by spared nerve injury model in mice
Huang-Chi Wang et al.
PHARMACEUTICAL BIOLOGY (2018)
Natural product andrographolide alleviated APAP-induced liver fibrosis by activating Nrf2 antioxidant pathway
Hongyu Yan et al.
TOXICOLOGY (2018)
Andrographolide attenuates viral myocarditis through interactions with the IL-10/STAT3 and P13K/AKT/NF- signaling pathways
Yaxin Zhao et al.
EXPERIMENTAL AND THERAPEUTIC MEDICINE (2018)
Andrographolide ameliorates intracerebral hemorrhage induced secondary brain injury by inhibiting neuroinflammation induction
Xiang Li et al.
NEUROPHARMACOLOGY (2018)
Andrographolide Alleviates Acute Brain Injury in a Rat Model of Traumatic Brain Injury: Possible Involvement of Inflammatory Signaling
Li Tao et al.
FRONTIERS IN NEUROSCIENCE (2018)
3-Dehydroandrographolide protects against lipopolysaccharide-induced inflammation through the cholinergic anti-inflammatory pathway
Zibin Lu et al.
BIOCHEMICAL PHARMACOLOGY (2018)
Dendritic cells in central nervous system autoimmunity
Christopher Sie et al.
SEMINARS IN IMMUNOPATHOLOGY (2017)
Andrographolide attenuates microglia-mediated Aβ neurotoxicity partially through inhibiting NF-κB and JNK MAPK signaling pathway
Rui Yang et al.
IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY (2017)
Andrographolide Benefits Rheumatoid Arthritis via Inhibiting MAPK Pathways
Zun-zhong Li et al.
INFLAMMATION (2017)
Multi-Targeting Andrographolide, a Novel NF-B Inhibitor, as a Potential Therapeutic Agent for Stroke
Chih-Hao Yang et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)
An ex vivo evaluation of the efficacy of andrographolide in modulating differential expression of transcription factors and target genes in periodontal cells and its potential role in treating periodontal diseases
R. Ambili et al.
JOURNAL OF ETHNOPHARMACOLOGY (2017)
Andrographolide - A promising therapeutic agent, negatively regulates glial cell derived neurodegeneration of prefrontal cortex, hippocampus and working memory impairment
Sudeshna Das et al.
JOURNAL OF NEUROIMMUNOLOGY (2017)
Andrographolide Activates Keap1/Nrf2/ARE/HO-1 Pathway in HT22 Cells and Suppresses Microglial Activation by A beta(42) through Nrf2-Related Inflammatory Response
Ji Yeon Seo et al.
MEDIATORS OF INFLAMMATION (2017)
Andrographolide inhibits influenza A virus-induced inflammation in a murine model through NF-κB and JAK-STAT signaling pathway
Yi Ding et al.
MICROBES AND INFECTION (2017)
Inhalable Andrographolide-β-cyclodextrin Inclusion Complexes for Treatment of Staphylococcus aureus Pneumonia by Regulating Immune Responses
Tongtong Zhang et al.
MOLECULAR PHARMACEUTICS (2017)
Prevention and treatment of cancer targeting chronic inflammation: research progress, potential agents, clinical studies and mechanisms
Yong Zhang et al.
SCIENCE CHINA-LIFE SCIENCES (2017)
Andrographolide enhanced 5-fluorouracil-induced antitumor effect in colorectal cancer via inhibition of c-MET pathway
Meng Su et al.
DRUG DESIGN DEVELOPMENT AND THERAPY (2017)
Andrographolide ameliorates d-galactosamine/lipopolysaccharide-induced acute liver injury by activating Nrf2 signaling pathway
Chen-wei Pan et al.
ONCOTARGET (2017)
Andrographolide Ameliorates Inflammation and Fibrogenesis and Attenuates Inflammasome Activation in Experimental Non-Alcoholic Steatohepatitis
Daniel Cabrera et al.
SCIENTIFIC REPORTS (2017)
Attenuation of Innate Immunity by Andrographolide Derivatives Through NF-κB Signaling Pathway
Xin Nie et al.
SCIENTIFIC REPORTS (2017)
Is there a future for andrographolide to be an anti-inflammatory drug? Deciphering its major mechanisms of action
W. S. Daniel Tan et al.
BIOCHEMICAL PHARMACOLOGY (2017)
Multi-targeting Andrographolide and its Natural Analogs as Potential Therapeutic Agents
V. Kishore et al.
CURRENT TOPICS IN MEDICINAL CHEMISTRY (2017)
Andrographolide alleviates imiquimod-induced psoriasis in mice via inducing autophagic proteolysis of MyD88
Fenli Shao et al.
BIOCHEMICAL PHARMACOLOGY (2016)
Andrographolide protects liver cells from H2O2 induced cell death by upregulation of Nrf-2/HO-1 mediated via adenosine A2a receptor signalling
Smriti P. K. Mittal et al.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2016)
Andrographolide-induced apoptosis in human renal tubular epithelial cells: Roles of endoplasmic reticulum stress and inflammatory response
Li-Li Gu et al.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY (2016)
Andrographis paniculata extract attenuates pathological cardiac hypertrophy and apoptosis in high-fat diet fed mice
You-Liang Hsieh et al.
JOURNAL OF ETHNOPHARMACOLOGY (2016)
Cigarette Smoke-Induced Lung Disease Predisposes to More Severe Infection with Nontypeable Haemophilus influenzae: Protective Effects of Andrographolide
W. S. Daniel Tang et al.
JOURNAL OF NATURAL PRODUCTS (2016)
A semisynthetic diterpenoid lactone inhibits NF-κB signalling to ameliorate inflammation and airway hyperresponsiveness in a mouse asthma model
J. C. -W. Lim et al.
TOXICOLOGY AND APPLIED PHARMACOLOGY (2016)
Andrographolide stimulates p38 mitogen-activated protein kinase-nuclear factor erythroid-2-related factor 2-heme oxygenase 1 signaling in primary cerebral endothelial cells for definite protection against ischemic stroke in rats
Ting-Lin Yen et al.
TRANSLATIONAL RESEARCH (2016)
Andrographolide suppresses thymic stromal lymphopoietin in phorbol myristate acetate/calcium ionophore A23187-activated mast cells and 2,4-dinitrofluorobenzene-induced atopic dermatitis-like mice model
Chun-xiao Li et al.
DRUG DESIGN DEVELOPMENT AND THERAPY (2016)
Andrographolide ameliorates OVA-induced lung injury in mice by suppressing ROS-mediated NF-κB signaling and NLRP3 inflammasome activation
Shuang Peng et al.
ONCOTARGET (2016)
Andrographolide sulfonate ameliorates lipopolysaccharide-induced acute lung injury in mice by down-regulating MAPK and NF-κB pathways
Shuang Peng et al.
ACTA PHARMACEUTICA SINICA B (2016)
Andrographolide derivative AL-1 ameliorates TNBS-induced colitis in mice: involvement of NF-κB and PPAR-γ signaling pathways
Yali Yang et al.
SCIENTIFIC REPORTS (2016)
Andrographolide Ameliorates Abdominal Aortic Aneurysm Progression by Inhibiting Inflammatory Cell Infiltration through Downregulation of Cytokine and Integrin Expression
Jun Ren et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2016)
Andrographolide activates the canonical Wnt signalling pathway by a mechanism that implicates the non-ATP competitive inhibition of GSK-3β: autoregulation of GSK-3β in vivo
Cheril Tapia-Rojas et al.
BIOCHEMICAL JOURNAL (2015)
Proteomic identification of mitochondrial targets involved in andrographolide sodium bisulfite-induced nephrotoxicity in a rat model
Wen Min Xing et al.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY (2015)
Andrographolide inhibits the migration, invasion and matrix metalloproteinase expression of rheumatoid arthritis fibroblast-like synoviocytes via inhibition of HIF-1α signaling
Guo-feng Li et al.
LIFE SCIENCES (2015)
Small molecule-driven mitophagy-mediated NLRP3 inflammasome inhibition is responsible for the prevention of colitis-associated cancer
Wenjie Guo et al.
AUTOPHAGY (2014)
Signaling pathway cross talk in Alzheimer's disease
Juan A. Godoy et al.
CELL COMMUNICATION AND SIGNALING (2014)
Andrographolide sodium bisulfate-induced apoptosis and autophagy in human proximal tubular endothelial cells is a ROS-mediated pathway
Hong Lu et al.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY (2014)
Andrographolide reduces cognitive impairment in young and mature AβPPswe/PS-1 mice
Felipe G. Serrano et al.
MOLECULAR NEURODEGENERATION (2014)
Neuroprotective effects of the andrographolide analogue AL-1 in the MPP+/MPTP-induced Parkinson's disease model in vitro and in mice
Zaijun Zhang et al.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR (2014)
Andrographolide protects against cigarette smoke-induced oxidative lung injury via augmentation of Nrf2 activity
S. P. Guan et al.
BRITISH JOURNAL OF PHARMACOLOGY (2013)
Andrographolide Protects against LPS-Induced Acute Lung Injury by Inactivation of NF-κB
Tao Zhu et al.
PLOS ONE (2013)
Andrographolide induces cell cycle arrest and apoptosis in human rheumatoid arthritis fibroblast-like synoviocytes
Jie Yan et al.
CELL BIOLOGY AND TOXICOLOGY (2012)
Andrographolide induces apoptosis in B16F-10 melanoma cells by inhibiting NF-κB-mediated bcl-2 activation and modulating p53-induced caspase-3 gene expression
P. Pratheeshkumar et al.
IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY (2012)
Protective Mechanism of Andrographolide against Carbon Tetrachloride-Induced Acute Liver Injury in Mice
Ju-Feng Ye et al.
BIOLOGICAL & PHARMACEUTICAL BULLETIN (2011)
Andrographolide Inhibits PI3K/AKT-Dependent NOX2 and iNOS Expression Protecting Mice against Hypoxia/Ischemia-Induced Oxidative Brain Injury
Chang-Ming Chern et al.
PLANTA MEDICA (2011)
Neuroprotective effects of andrographolide in a rat model of permanent cerebral ischaemia
Su Jing Chan et al.
BRITISH JOURNAL OF PHARMACOLOGY (2010)
Efficacy of an Andrographis paniculata composition for the relief of rheumatoid arthritis symptoms: a prospective randomized placebo-controlled trial
R. A. Burgos et al.
CLINICAL RHEUMATOLOGY (2009)
Absorption of andrographolides from Andrographis paniculata and its effect on CCl4-induced oxidative stress in rats
G. A. Akowuah et al.
FOOD AND CHEMICAL TOXICOLOGY (2009)
Modulation of nuclear factor-κB activity can influence the susceptibility to systemic lupus erythematosus
Alexis M. Kalergis et al.
IMMUNOLOGY (2009)
Reproductive and Fertility Effects of an Extract of Andrographis paniculata in Male Wistar Rats
J. Joshua Allan et al.
INTERNATIONAL JOURNAL OF TOXICOLOGY (2009)
Strong synergistic induction of CYP1A1 expression by andrographolide plus typical CYP1A inducers in mouse hepatocytes
Atika Jaruchotikamol et al.
TOXICOLOGY AND APPLIED PHARMACOLOGY (2007)
Inhibition of nuclear factor-κB enhances the capacity of immature dendritic cells to induce antigen-specific tolerance in experimental autoimmune encephalomyelitis
Mirentxu I. Iruretagoyena et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2006)
Andrographolide interferes with T cell activation and reduces experimental autoimmune encephalomyelitis in the mouse
MI Iruretagoyena et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2005)
Andrographolide reduces inflammation-mediated dopaminergic neurodegeneration in mesencephalic neuron-glia cultures by inhibiting microglial activation
TG Wang et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2004)
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