期刊
FRONTIERS IN PHARMACOLOGY
卷 13, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fphar.2022.920435
关键词
andrographolide; inflammatory diseases; anti-inflammation; immunomodulation; review
资金
- National Natural Science Foundation of China
- Science and Technology Foundation of Shandong Traditional Chinese Medicine [82004249]
- [2021Q078]
Andrographolide, a natural active ingredient derived from Andrographis paniculata, has anti-inflammatory effects and can be used to treat various inflammatory diseases. It acts on multiple inflammation-related signaling pathways and has potential clinical applications.
Botanicals have attracted much attention in the field of anti-inflammatory due to their good pharmacological activity and efficacy. Andrographis paniculata is a natural plant ingredient that is widely used around the world. Andrographolide is the main active ingredient derived from Andrographis paniculata, which has a good effect on the treatment of inflammatory diseases. This article reviews the application, anti-inflammatory mechanism and molecular targets of andrographolide in different inflammatory diseases, including respiratory, digestive, immune, nervous, cardiovascular, skeletal, and tumor system diseases. And describe its toxicity and explain its safety. Studies have shown that andrographolide can be used to treat inflammatory lesions of various systemic diseases. In particular, it acts on many inflammation-related signalling pathways. The future direction of andrographolide research is also introduced, as is the recent research that indicates its potential clinical application as an anti-inflammatory agent.
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