期刊
FRONTIERS IN PHARMACOLOGY
卷 13, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fphar.2022.1007746
关键词
phytopharmacology; adulteration; purity; extraction process; ginkgolides; proanthocyanidins; flavonoids; bilobalide
资金
- Dr. Willmar Schwabe GmbH and Co., KG, Germany
The phytochemical composition of extracts derived from the same plant can vary significantly, affecting their pharmacokinetic and pharmacodynamic properties, and ultimately their clinical efficacy and safety. Regulating active constituent levels and reducing undesired substances is vital for ensuring the quality and consistency of herbal extracts. The heterogeneity of extracts should be carefully considered when evaluating the efficacy and safety of plant-derived remedies.
It is an often-neglected fact that extracts derived from the very same plant can differ significantly in their phytochemical composition, and thus also in their pharmacokinetic and pharmacodynamic properties which are the basis for their clinical efficacy and safety. The Ginkgo biloba L. [Ginkgoaceae] special extract EGb 761 (R) is one of the best-studied plant extracts in the world. In the present review, using that extract as a paradigm, we describe insights how climate, the harvest region, processing of the plant material, the drying process, the extraction solvents, and the details of the subsequent process steps substantially impact the quality and uniformity of the final extract. We highlight the importance of regulating active constituent levels and consistent reduction of undesired substances in herbal extracts. This is accomplished by a controlled production process and corresponding analytical specifications. In conclusion, since extracts derived from the same plant can have very different phytochemical compositions, results from pharmacological, toxicological and clinical studies gained with one specific extract cannot be extrapolated to other extracts that were generated using different production processes. We propose that the heterogenous nature of extracts should be meticulously considered when evaluating the efficacy and safety of plant-derived remedies.
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