Heidihuangwan alleviates renal fibrosis in rats with 5/6 nephrectomy by inhibiting autophagy

Article Cardiac & Cardiovascular Systems

Catalpol Alleviates Ang II-Induced Renal Injury Through NF-κB Pathway and TGF-β1/Smads Pathway

Cong Cong et al.

Summary: Catalpol can alleviate Ang II-induced renal injury by inactivating NF-kappa B and TGF-beta 1/Smads signaling pathways.

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY (2022)

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Article Biochemistry & Molecular Biology

Anti-Fibrotic Effect of Synthetic Noncoding Oligodeoxynucleotide for Inhibiting mTOR and STAT3 via the Regulation of Autophagy in an Animal Model of Renal Injury

Hyun Jin Jung et al.

Summary: Renal fibrosis, a common process in kidney diseases, and autophagy, an important cellular process, are closely related. This study investigates the effects of mTOR/STAT3 ODN on renal fibrosis and autophagy regulation. The findings suggest that mTOR/STAT3 ODN can suppress inflammation and fibrosis, and further research is needed to understand its role in autophagy regulation.

MOLECULES (2022)

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Article Biochemistry & Molecular Biology

Hydroxychloroquine alleviates renal interstitial fibrosis by inhibiting the PI3K/Akt signaling pathway

Dengren Li et al.

Summary: This study found that hydroxychloroquine (HCQ) can alleviate inflammation and cell apoptosis caused by renal fibrosis by inhibiting the activation of the PI3K/AKT and NF-kB pathways, improving the epithelial-mesenchymal transition (EMT) and extracellular matrix (ECM) deposition in renal tubular epithelial cells. This provides theoretical evidence for the treatment of renal fibrosis with HCQ.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2022)

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Article Cell Biology

DNMT3a negatively regulates PTEN to activate the PI3K/AKT pathway to aggravate renal fibrosis

Taotao Hu et al.

Summary: In this study, the relationship between PTEN methylation and renal fibrosis was investigated. It was found that PTEN promoter region was methylated in a mouse model of unilateral ureteral obstruction (UUO), and the expression of PTEN was significantly reduced in the UUO group. Furthermore, DNMT3a negatively regulated PTEN to activate the PI3K/AKT signaling pathway and induce EMT in renal tubular epithelial cells, aggravating renal fibrosis.

CELLULAR SIGNALLING (2022)

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Article Integrative & Complementary Medicine

Jieduquyuzishen Prescription Attenuates Renal Fibrosis in MRL/lpr Mice via Inhibiting EMT and TGF-β1/Smad2/3 Pathway

Shan Wu et al.

Summary: The study found that Jieduquyuziyin prescription (JP) has therapeutic effects on lupus nephritis, alleviating disease activity, improving renal function, reducing proteinuria, and improving renal injury and fibrosis. This may be achieved through the inhibition of epithelial-mesenchymal transition (EMT) and the activation of the TGF-beta 1/Smad2/3 signaling pathway.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2022)

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Article Biochemistry & Molecular Biology

Mitophagy induced by UMI-77 preserves mitochondrial fitness in renal tubular epithelial cells and alleviates renal fibrosis

Lini Jin et al.

Summary: Activation of mitophagy improves mitochondrial health, reduces TGF-beta 1/Smad signaling, alleviates TEC injuries, and decreases inflammatory infiltration in the kidneys.

FASEB JOURNAL (2022)

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Article Urology & Nephrology

Berberine protects diabetic nephropathy by suppressing epithelial-to-mesenchymal transition involving the inactivation of the NLRP3 inflammasome

Zejun Ma et al.

Summary: This study demonstrates that berberine can alleviate tubulointerstitial fibrosis and epithelial-to-mesenchymal transition (EMT) in diabetic kidney disease (DKD) by suppressing the NLRP3 inflammasome. Berberine may serve as a novel drug to improve tubulointerstitial fibrosis in DKD.

RENAL FAILURE (2022)

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Article Urology & Nephrology

Pentosan polysulfate ameliorates fibrosis and inflammation markers in SV40 MES13 cells by suppressing activation of PI3K/AKT pathway via miR-446a-3p

Liangxiang Xiao et al.

Summary: The study found that PPS can protect SV40 MES13 cells from AGEs-induced toxicity by altering the miRNA expression profile, and subsequently inhibit the activation of the PI3K/AKT pathway through miR-466a-3p.

BMC NEPHROLOGY (2022)

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Article Chemistry, Medicinal

Astragaloside IV Alleviates Renal Tubular Epithelial-Mesenchymal Transition via CX3CL1-RAF/MEK/ERK Signaling Pathway in Diabetic Kidney Disease

Yonghui Hu et al.

Summary: This study found that AS-IV can alleviate renal tubular EMT in DKD patients by regulating CX3CL1, thereby reducing renal pathological damage.

DRUG DESIGN DEVELOPMENT AND THERAPY (2022)

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Article Pharmacology & Pharmacy

Network Pharmacology and Experimental Verification Strategies to Illustrate the Mechanism of Jian-Pi-Yi-Shen Formula in Suppressing Epithelial-Mesenchymal Transition

Yuan Zhao et al.

Summary: This study combines network pharmacology and experimental verification to elucidate the potential mechanism of the traditional Chinese medicine Jian-Pi-Yi-Shen formula (JPYSF) in treating renal fibrosis by inhibiting epithelial-mesenchymal transition (EMT). The results show that JPYSF effectively targets EMT through multiple pathways, including the Wnt3a/beta-catenin signaling pathway, and improves interstitial fibrosis in rats. These findings provide insights into the renoprotective effects of JPYSF against EMT, suggesting its potential in attenuating renal fibrosis.

FRONTIERS IN PHARMACOLOGY (2022)

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Review Biochemistry & Molecular Biology

Network Pharmacology and Experimental Validation to Reveal the Pharmacological Mechanisms of Chongcaoyishen Decoction Against Chronic Kidney Disease

Zhenliang Fan et al.

Summary: This study explored the pharmacological mechanisms of Chongcaoyishen decoction (CCYSD) against chronic kidney disease (CKD) through network pharmacology analysis and experimental validation. The results indicate that CCYSD may exert its pharmacological effects by activating autophagy, promoting mitochondrial degradation, and reducing tissue oxidative stress injury.

FRONTIERS IN MOLECULAR BIOSCIENCES (2022)

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Review Biochemistry & Molecular Biology

Therapeutic Implications of Ferroptosis in Renal Fibrosis

Yao Zhang et al.

Summary: This paper reviews the relationship between renal fibrosis and ferroptosis from the perspective of iron metabolism and lipid peroxidation. It summarizes some pharmaceuticals or chemicals associated with both ferroptosis and renal fibrosis. Additionally, other programmed cell death and ferroptosis in renal fibrosis are also reviewed for comparison and further investigation.

FRONTIERS IN MOLECULAR BIOSCIENCES (2022)

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Article Biochemical Research Methods

The Anti-hyperuricemia and Anti-inflammatory Effects of Atractylodes Macrocephala in Hyperuricemia and Gouty Arthritis Rat Models

Xvwu Qian et al.

COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING (2022)

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Article Anatomy & Morphology

Astragaloside IV attenuated TGF-β1-induced epithelial-mesenchymal transition of renal tubular epithelial cells via connexin 43 and Akt/mTOR signaling pathway

Yonghong Lian et al.

Summary: This study aimed to investigate the role of connexin 43 (Cx43) in regulating epithelial mesenchymal transformation (EMT) of renal tubular epithelial cells (RTECs) through the Akt/mTOR signaling pathway and the potential inhibitory effect of Astragaloside IV (ASV) on renal interstitial fibrosis by regulating Cx43. The results showed that Cx43 played a significant role in RTECs injury and that ASV could inhibit TGF-beta 1-induced RTECs transdifferentiation. Further investigation of this mechanism may provide promising therapeutic strategies for the treatment of renal interstitial fibrosis.

TISSUE & CELL (2022)

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Article Immunology

FuZhengHuaYuJiangZhuTongLuoFang Prescription Modulates Gut Microbiota and Gut-Derived Metabolites in UUO Rats

Ziwei Chen et al.

Summary: FZHY treatment effectively reduces kidney damage in the early stages of CKD by regulating gut bacteria and metabolites, inhibiting inflammation responses, and reducing tubulointerstitial fibrosis.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2022)

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Article Cardiac & Cardiovascular Systems

Catalpol Alleviates Ang II-Induced Renal Injury Through NF-κB Pathway and TGF-β1/Smads Pathway

Cong Cong et al.

Summary: This study suggests that catalpol may have potential therapeutic value in treating Ang II-induced renal injury by inhibiting the NF-κB and TGF-beta 1/Smads signaling pathways.

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY (2022)

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Article Surgery

Protective effect and mechanism of Shenkang injection on adenine-induced chronic renal failure in rats

Rongchang Chen et al.

Summary: The study showed that Shenkang injection (SKI) had protective effects against adenine-induced chronic renal failure (CRF) in rats. SKI inhibited kidney injury and fibrosis, reduced inflammatory cytokine release, and increased antioxidant enzyme activity, demonstrating its anti-inflammatory and antioxidant effects.

ACTA CIRURGICA BRASILEIRA (2022)

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Review Pharmacology & Pharmacy

Therapeutic and delivery strategies of phytoconstituents for renal fibrosis

Huan Xu et al.

Summary: CKD is a common disease endangering human health and life, with RF being an important intermediate link in the progression of CKD. Active phytoconstituents extracted from various plants have potential therapeutic capabilities in RF treatment and can be structurally modified or combined with other ingredients to enhance efficiency and reduce toxicity. Delivery strategies of phytoconstituents can overcome renal barriers, improve bioavailability, and targeting in RF treatment.

ADVANCED DRUG DELIVERY REVIEWS (2021)

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Article Pharmacology & Pharmacy

Curcumin attenuates renal interstitial fibrosis by regulating autophagy and retaining mitochondrial function in unilateral ureteral obstruction rats

Miaomiao Lu et al.

Summary: Curcumin has shown promising effects in attenuating renal interstitial fibrosis in UUO rats by inhibiting NLRP3 inflammasome activation, improving mitochondrial function, and promoting autophagy. Its mechanism of action also involves inhibiting the PI3K/AKT/mTOR pathway.

BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY (2021)

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Article Food Science & Technology

Nicotinamide Attenuates the Progression of Renal Failure in a Mouse Model of Adenine-Induced Chronic Kidney Disease

Satoshi Kumakura et al.

Summary: NAD(+) plays a crucial role in kidney disease by promoting ATP generation for energy oxidation and anti-inflammatory reactions. Supplementation of the NAD(+) precursor nicotinamide can reduce kidney inflammation and fibrosis, potentially preventing disease progression.

TOXINS (2021)

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Article Pharmacology & Pharmacy

Astragalus Polysaccharide Reduces Blood Pressure, Renal Damage, and Dysfunction Through the TGF-β1-ILK Pathway

Wei Zheng et al.

Summary: Astragalus polysaccharide extract (APS) has been shown to significantly reduce blood pressure in hypertensive mice, reduce inflammation and renal fibrosis, and improve renal function. In addition, APS administration can alleviate the increase in serum creatinine, urea nitrogen, and uric acid levels.

FRONTIERS IN PHARMACOLOGY (2021)

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Article Urology & Nephrology

microRNA-29b prevents renal fibrosis by attenuating renal tubular epithelial cell-mesenchymal transition through targeting the PI3K/AKT pathway

Shuang Hu et al.

Summary: The study demonstrated that miR-29b could prevent renal interstitial fibrosis in a mouse model of unilateral ureteral obstruction by inhibiting the PI3K/AKT signaling pathway, leading to decreased fibrosis and modulation of epithelial-mesenchymal transition.

INTERNATIONAL UROLOGY AND NEPHROLOGY (2021)

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Article Pharmacology & Pharmacy

Yiqi Jiedu Huayu Decoction Alleviates Renal Injury in Rats With Diabetic Nephropathy by Promoting Autophagy

Chen Xuan et al.

Summary: The study found that YJHD can effectively improve renal function, alleviate renal pathological injury, protect podocytes, and reduce renal fibrosis. The mechanism may be related to the promotion of autophagy, inhibition of the mTOR pathway, and regulation of the PI3K/Akt and AMPK pathways.

FRONTIERS IN PHARMACOLOGY (2021)

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Article Cell Biology

Resveratrol Attenuates Oxalate-Induced Renal Oxidative Injury and Calcium Oxalate Crystal Deposition by Regulating TFEB-Induced Autophagy Pathway

Yue Wu et al.

Summary: The study showed that resveratrol can reverse renal inflammation, oxidative injury, and CaOx crystal deposition induced by oxalate through the induction of autophagy. Additionally, resveratrol promotes the upregulation of LC3II, downregulation of p62, and the formation of autophagosomes in renal tubular epithelial cells.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Article Medicine, Research & Experimental

Role of autophagy and evaluation the effects of microRNAs 214, 132, 34c and prorenin receptor in a rat model of focal segmental glomerulosclerosis

Derya Yildirim et al.

Summary: This study investigated the role of autophagy in the pathogenesis of FSGS, revealing that decreased autophagic activity and PRR expression play important roles in the disease process. miR-34c, miR-132, and miR-214 may serve as potential treatment strategies by regulating autophagy.

LIFE SCIENCES (2021)

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Article Food Science & Technology

In Vitro and In Vivo Antifibrotic Effects of Fraxetin on Renal Interstitial Fibrosis via the ERK Signaling Pathway

Yi-Hsien Hsieh et al.

Summary: Fraxetin has been shown to decrease renal dysfunction and reduce renal interstitial collagen fibers in a mouse model of renal fibrosis, while inhibiting the expression of key proteins involved in fibrosis. This suggests that fraxetin may be beneficial in slowing the progression of chronic kidney disease.

TOXINS (2021)

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Article Food Science & Technology

The Protein-Independent Role of Phosphate in the Progression of Chronic Kidney Disease

Irene Faria Duayer et al.

Summary: The study found that a high-phosphate diet may exacerbate the progression of chronic kidney disease, leading to renal interstitial inflammation and fibrosis, with phosphate possibly playing a role in dysregulating the renal cell autophagy mechanism.

TOXINS (2021)

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Review Geriatrics & Gerontology

Autophagy and Renal Fibrosis

Shan Liang et al.

Summary: Renal fibrosis is a common process in chronic kidney diseases, and autophagy plays an important role in maintaining intracellular homeostasis. Although the specific role of autophagy in renal fibrosis is not fully understood, recent advances have shed light on its functions in this progression.

AGING AND DISEASE (2021)

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Article Cell Biology

Podocytes maintain high basal levels of autophagy independent of mtor signaling

Tillmann Bork et al.

AUTOPHAGY (2020)

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Article Medicine, General & Internal

Global, regional, and national burden of chronic kidney disease, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017

Boris Bikbov et al.

LANCET (2020)

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Article Integrative & Complementary Medicine

Oleanolic Acid Attenuates Renal Fibrosis through TGF-β/Smad Pathway in a Rat Model of Unilateral Ureteral Obstruction

Zhao Dapeng et al.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2020)

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Review Urology & Nephrology

Autophagy in kidney homeostasis and disease

Chengyuan Tang et al.

NATURE REVIEWS NEPHROLOGY (2020)

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Article Medicine, Research & Experimental

Astragaloside IV inhibits excessive mesangial cell proliferation and renal fibrosis caused by diabetic nephropathy via modulation of the TGF-β1/Smad/miR-192 signaling pathway

Qian Mao et al.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2019)

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Article Medicine, Research & Experimental

Effect of ATM on inflammatory response and autophagy in renal tubular epithelial cells in LPS-induced septic AKI

Chenfei Zheng et al.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2019)

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Article Medicine, Research & Experimental

Astragaloside IV ameliorates high glucose-induced renal tubular epithelial-mesenchymal transition by blocking mTORC1/p70S6K signaling in HK-2 cells

Xiao Chen et al.

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2019)

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Review Cell & Tissue Engineering

Mesenchymal Stem Cells in Renal Fibrosis: The Flame of Cytotherapy

Quan Zhuang et al.

STEM CELLS INTERNATIONAL (2019)

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Article Pharmacology & Pharmacy

Cryptotanshinone Attenuates Oxidative Stress and Inflammation through the Regulation of Nrf-2 and NF-kappa B in Mice with Unilateral Ureteral Obstruction

Wei Wang et al.

BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY (2018)

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Article Medicine, Research & Experimental

Ferulic acid protects lipopolysaccharide-induced acute kidney injury by suppressing inflammatory events and upregulating antioxidant defenses in Balb/c mice

Salma Mukhtar Mir et al.

BIOMEDICINE & PHARMACOTHERAPY (2018)

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Article Chemistry, Medicinal

A stragaloside IV represses high glucose-induced mesangial cells activation by enhancing autophagy via SIRT1 deacetylation of NF-kappa B p65 subunit

Xiaolei Wang et al.

DRUG DESIGN DEVELOPMENT AND THERAPY (2018)

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Article Medicine, General & Internal

Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017

Spencer L. G. James et al.

LANCET (2018)

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Article Medicine, General & Internal

Global, regional, and national disability-adjusted life-years (DALYs) for 359 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017

Hmwe Hmwe Kyu et al.

LANCET (2018)

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Article Medicine, General & Internal

Global, regional, and national age-sex-specific mortality for 282 causes of death in 195 countries and territories, 1980-2017: a systematic analysis for the Global Burden of Disease Study 2017

Gregory A. Roth et al.

LANCET (2018)

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Review Cell Biology

Signalling pathways involved in hypoxia-induced renal fibrosis

Minna Liu et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2017)

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Article Physiology

UCP2 attenuates apoptosis of tubular epithelialcells in renal ischemia-reperfusion injury

Yang Zhou et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2017)

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Article Immunology

Rutin ameliorates kidney interstitial fibrosis in rats with obstructive nephropathy

Bin Wang et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2016)

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Review Cell Biology

TGF-beta 1/Smads and miR-21 in Renal Fibrosis and Inflammation

Agnieszka Loboda et al.

MEDIATORS OF INFLAMMATION (2016)

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Review Urology & Nephrology

Developmental signalling pathways in renal fibrosis: the roles of Notch, Wnt and Hedgehog

Maria Edeling et al.

NATURE REVIEWS NEPHROLOGY (2016)

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Article Multidisciplinary Sciences

IGF-1 protects tubular epithelial cells during injury via activation of ERK/MAPK signaling pathway

Zengbin Wu et al.

SCIENTIFIC REPORTS (2016)

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Article Cell & Tissue Engineering

Bone Marrow-Derived Mesenchymal Stem Cells and Their Conditioned Medium Attenuate Fibrosis in an Irreversible Model of Unilateral Ureteral Obstruction

Andrei F. da Silva et al.

CELL TRANSPLANTATION (2015)

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Article Biochemistry & Molecular Biology

Trans-10,cis-12-conjugated linoleic acid worsens renal pathology and alters cyclooxygenase derived oxylipins in obesity-associated nephropathy

Yang Zhan et al.

JOURNAL OF NUTRITIONAL BIOCHEMISTRY (2015)

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Article Urology & Nephrology

Telomerase deficiency delays renal recovery in mice after ischemia-reperfusion injury by impairing autophagy

Huifang Cheng et al.

KIDNEY INTERNATIONAL (2015)

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Article Medicine, Research & Experimental

Increased adenosine levels contribute to ischemic kidney fibrosis in the unilateral ureteral obstruction model

Jin Tang et al.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2015)

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Article Toxicology

Protective activity of gallic acid against glyoxal -induced renal fibrosis in experimental rats

Mohammed Jainuddin Yousuf et al.

TOXICOLOGY REPORTS (2015)

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Article Urology & Nephrology

New Autophagy Reporter Mice Reveal Dynamics of Proximal Tubular Autophagy

Ling Li et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2014)

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Article Cell Biology

Autophagy plays a critical role in kidney tubule maintenance, aging and ischemia-reperfusion injury

Shuya Liu et al.

AUTOPHAGY (2012)

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Article Urology & Nephrology

The role of autophagy in unilateral ureteral obstruction rat model

Wan-Young Kim et al.

NEPHROLOGY (2012)

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Article Pathology

Autophagy Is a Component of Epithelial Cell Fate in Obstructive Uropathy

Ling Li et al.

AMERICAN JOURNAL OF PATHOLOGY (2010)

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Heidihuangwan alleviates renal fibrosis in rats with 5/6 nephrectomy by inhibiting autophagy

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