期刊
FRONTIERS IN PHARMACOLOGY
卷 13, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fphar.2022.1018951
关键词
thiosemicarbazone; schiff base; metal complexes; anti-lung cancer; chemotherapy
资金
- Henan Engineering Technology Research Center of Funiu Mountain Medicinal Resource Utilization and Molecular Medicine, Key Science and Technology Research Projects in Henan Provincial [202102310476]
- Key scientific research project of henan Province [22A530005]
- Youth Fund of Pingdingshan College [PXY-QNJJ-202110]
- Pingdingshan College PhD Startup Fund [PXY-BSQD-202003]
Thiosemicarbazone Schiff base complexes have the potential to be effective anti-lung cancer drugs, and their structural diversity offers pharmaceutical chemists a wide range of possibilities. These ligands and complexes play crucial roles in anti-lung cancer treatment, but there are still challenges to overcome.
The great success of cisplatin as a chemotherapeutic agent considerably increased research efforts in inorganic biochemistry to identify more metallic drugs having the potential of treating lung cancer. Metal coordination centres, which exhibit a wide range of coordination numbers and geometries, various oxidised and reduced states and the inherent ligand properties offer pharmaceutical chemists a plethora of drug structures. Owing to the presence of C=N and C=S bonds in a thiosemicarbazone Schiff base, N and S atoms in its hybrid orbital has lone pair of electrons, which can generate metal complexes with different stabilities with most metal elements under certain conditions. Such ligands and complexes play key roles in the treatment of anti-lung cancer. Research regarding metallic anti-lung cancer has advanced considerably, but there remain several challenges. In this review, we discuss the potential of thiosemicarbazone Schiff base complexes as anti-lung cancer drugs, their anti-cancer activities and the most likely action mechanisms involving the recent families of copper, nickel, platinum, ruthenium and other complexes.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据