相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。The E3 Ubiquitin Ligase TRAF6 Interacts with the Cellular Prion Protein and Modulates Its Solubility and Recruitment to Cytoplasmic p62/SQSTM1-Positive Aggresome-Like Structures
Lara Masperone et al.
MOLECULAR NEUROBIOLOGY (2022)
Selective Autophagy Receptor p62/SQSTM1, a Pivotal Player in Stress and Aging
Anita V. Kumar et al.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2022)
Don't forget to be picky - selective autophagy of protein aggregates in neurodegenerative diseases
Anne Simonsen et al.
CURRENT OPINION IN CELL BIOLOGY (2022)
Making the Case for Accelerated Withdrawal of Aducanumab
Peter Whitehouse et al.
JOURNAL OF ALZHEIMERS DISEASE (2022)
Prion protein monoclonal antibody (PRN100) therapy for Creutzfeldt–Jakob disease: evaluation of a first-in-human treatment programme
Simon Mead et al.
LANCET NEUROLOGY (2022)
Can We Treat Neurodegenerative Proteinopathies by Enhancing Protein Degradation?
Simone Engelender et al.
MOVEMENT DISORDERS (2022)
Faulty autolysosome acidification in Alzheimer's disease mouse models induces autophagic build-up of Aβ in neurons, yielding senile plaques
Ju-Hyun Lee et al.
NATURE NEUROSCIENCE (2022)
Deciphering the prion-like behavior of pathogenic protein aggregates in neurodegenerative diseases
Shun Yoshida et al.
NEUROCHEMISTRY INTERNATIONAL (2022)
Proteostatic regulation in neuronal compartments
Stefano L. Giandomenico et al.
TRENDS IN NEUROSCIENCES (2022)
Mechanisms of neuronal survival safeguarded by endocytosis and autophagy
Melina Overhoff et al.
JOURNAL OF NEUROCHEMISTRY (2021)
Ubiquitin signaling in neurodegenerative diseases: an autophagy and proteasome perspective
Francois Le Guerroue et al.
CELL DEATH AND DIFFERENTIATION (2021)
Structure and function of p62/SQSTM1 in the emerging framework of phase separation
Sabrina Berkamp et al.
FEBS JOURNAL (2021)
Molecular and cellular dynamics of the 26S proteasome
Eri Sakata et al.
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (2021)
Adapting the proteostasis capacity to sustain brain healthspan
Claudio Hetz
CELL (2021)
Aducanumab produced a clinically meaningful benefit in association with amyloid lowering
Jeffrey Cummings et al.
ALZHEIMERS RESEARCH & THERAPY (2021)
Chaperone-mediated autophagy: a gatekeeper of neuronal proteostasis
Mathieu Bourdenx et al.
AUTOPHAGY (2021)
EVOO Polyphenols Relieve Synergistically Autophagy Dysregulation in a Cellular Model of Alzheimer's Disease
Manuela Leri et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)
Defective Autophagy and Mitophagy in Alzheimer's Disease: Mechanisms and Translational Implications
Jie Chen et al.
MOLECULAR NEUROBIOLOGY (2021)
Extracellular vesicles (exosomes and ectosomes) play key roles in the pathology of brain diseases
Jacopo Meldolesi
MOLECULAR BIOMEDICINE (2021)
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)
Daniel J. Klionsky et al.
AUTOPHAGY (2021)
Impairment of autophagy in scrapie-infected transgenic mice at the clinical stage
Oscar Lopez-Perez et al.
LABORATORY INVESTIGATION (2020)
Metformin reduces prion infection in neuronal cells by enhancing autophagy
Dalia H. Abdelaziz et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2020)
Ubiquitin biology in neurodegenerative disorders: From impairment to therapeutic strategies
Dhiraj Kumar et al.
AGEING RESEARCH REVIEWS (2020)
The Braak hypothesis in prion disease with a focus on Creutzfeldt-Jakob disease
Yasushi Iwasaki
NEUROPATHOLOGY (2020)
Extracellular vesicles: where the amyloid precursor protein carboxyl-terminal fragments accumulate and amyloid-β oligomerizes
Rocio Perez-Gonzalez et al.
FASEB JOURNAL (2020)
Co-Chaperones in Targeting and Delivery of Misfolded Proteins to the 26S Proteasome
Amanda B. Abildgaard et al.
BIOMOLECULES (2020)
Trehalose Inhibits Aβ Generation and Plaque Formation in Alzheimer's Disease
Yuhang Liu et al.
MOLECULAR NEUROBIOLOGY (2020)
Molecular Chaperones: A Double-Edged Sword in Neurodegenerative Diseases
Jessica Tittelmeier et al.
FRONTIERS IN AGING NEUROSCIENCE (2020)
Autophagy Activator Drugs: A New Opportunity in Neuroprotection from Misfolded Protein Toxicity
Stefano Thellung et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)
The prion-like propagation hypothesis in Alzheimer's and Parkinson's disease
Charles Duyckaerts et al.
CURRENT OPINION IN NEUROLOGY (2019)
Clinical trials of prion disease therapeutics
Gianluigi Forloni et al.
CURRENT OPINION IN PHARMACOLOGY (2019)
Prion disease is accelerated in mice lacking stress-induced heat shock protein 70 (HSP70)
Charles E. Mays et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2019)
mTOR hyperactivation in Down Syndrome underlies deficits in autophagy induction, autophagosome formation, and mitophagy
Matteo Bordi et al.
CELL DEATH & DISEASE (2019)
Transmissibility versus Pathogenicity of Self-Propagating Protein Aggregates
Byron Caughey et al.
VIRUSES-BASEL (2019)
Polyubiquitin chain-induced p62 phase separation drives autophagic cargo segregation
Daxiao Sun et al.
CELL RESEARCH (2018)
p62 filaments capture and present ubiquitinated cargos for autophagy
Gabriele Zaffagnini et al.
EMBO JOURNAL (2018)
Dysfunction of autophagy and endosomal-lysosomal pathways: Roles in pathogenesis of Down syndrome and Alzheimer's Disease
Daniel J. Colacurcio et al.
FREE RADICAL BIOLOGY AND MEDICINE (2018)
Astemizole Inhibits mTOR Signaling and Angiogenesis by Blocking Cholesterol Trafficking
Junfang Lyu et al.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2018)
Autophagy regulates exosomal release of prions in neuronal cells
Basant A. Abdulrahman et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2018)
Rapamycin treatment for amyotrophic lateral sclerosis Protocol for a phase II randomized, double-blind, placebo-controlled, multicenter, clinical trial (RAP-ALS trial)
Jessica Mandrioli et al.
MEDICINE (2018)
Prions, prionoids and protein misfolding disorders
Claudia Scheckel et al.
NATURE REVIEWS GENETICS (2018)
Pharmacological activation of autophagy favors the clearing of intracellular aggregates of misfolded prion protein peptide to prevent neuronal death
Stefano Thellung et al.
CELL DEATH & DISEASE (2018)
A common mechanism of proteasome impairment by neurodegenerative disease-associated oligomers
Tiffany A. Thibaudeau et al.
NATURE COMMUNICATIONS (2018)
Aging and Proteins: What Does Proteostasis Have to Do with Age?
S. Magalhaes et al.
CURRENT MOLECULAR MEDICINE (2018)
The interplay between exosomes and autophagy - partners in crime
Jing Xu et al.
JOURNAL OF CELL SCIENCE (2018)
Doxycycline in early CJD: a double-blinded randomised phase II and observational study
Daniela Varges et al.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2017)
Overexpression of PLK3 Mediates the Degradation of Abnormal Prion Proteins Dependent on Chaperone-Mediated Autophagy
Hui Wang et al.
MOLECULAR NEUROBIOLOGY (2017)
Sporadic and Infectious Human Prion Diseases
Robert G. Will et al.
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2017)
Different Molecular Mechanisms Mediate Direct or Glia-Dependent Prion Protein Fragment 90-231 Neurotoxic Effects in Cerebellar Granule Neurons
Stefano Thellung et al.
NEUROTOXICITY RESEARCH (2017)
Protein Quality Control by Molecular Chaperones in Neurodegeneration
Aaron Ciechanover et al.
FRONTIERS IN NEUROSCIENCE (2017)
The Endoplasmic Reticulum Chaperone GRP78/BiP Modulates Prion Propagation in vitro and in vivo
Kyung-Won Park et al.
SCIENTIFIC REPORTS (2017)
Metformin Inhibits Hepatic mTORC1 Signaling via Dose-Dependent Mechanisms Involving AMPK and the TSC Complex
Jessica J. Howell et al.
CELL METABOLISM (2017)
Familial prion protein mutants inhibit Hrd1-mediated retrotranslocation of misfolded proteins by depleting misfolded protein sensor BiP
Sarah L. Peters et al.
HUMAN MOLECULAR GENETICS (2016)
Metformin Prevents Dopaminergic Neuron Death in MPTP/P-Induced Mouse Model of Parkinson's Disease via Autophagy and Mitochondrial ROS Clearance
Ming Lu et al.
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY (2016)
Stimulating the Release of Exosomes Increases the Intercellular Transfer of Prions
Belinda B. Guo et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2016)
Trehalose Alters Subcellular Trafficking and the Metabolism of the Alzheimer-associated Amyloid Precursor Protein
Nguyen T. Tien et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2016)
Mystery solved: Trehalose kickstarts autophagy by blocking glucose transport
Pablo Mardones et al.
SCIENCE SIGNALING (2016)
Dysregulation of Ubiquitin-Proteasome System in Neurodegenerative Diseases
Qiuyang Zheng et al.
FRONTIERS IN AGING NEUROSCIENCE (2016)
Mystery solved: Trehalose kickstarts autophagy by blocking glucose transport
Pablo Mardones et al.
SCIENCE SIGNALING (2016)
p62/SQSTM1 functions as a signaling hub and an autophagy adaptor
Yoshinori Katsuragi et al.
FEBS JOURNAL (2015)
Polo-like kinase 3 (PLK3) mediates the clearance of the accumulated PrP mutants transiently expressed in cultured cells and pathogenic PrPSc in prion infected cell line via protein interaction
Hui Wang et al.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2015)
The unravelling of the ubiquitin system
Aaron Ciechanover
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2015)
Preventive study in subjects at risk of fatal familial insomnia: Innovative approach to rare diseases
Gianluigi Forloni et al.
PRION (2015)
Ubiquitin-specific protease 14 modulates degradation of cellular prion protein
Takujiro Homma et al.
SCIENTIFIC REPORTS (2015)
Bcl-2 Decreases the Affinity of SQSTM1/p62 to Poly-Ubiquitin Chains and Suppresses the Aggregation of Misfolded Protein in Neurodegenerative Disease
Liang Zhou et al.
MOLECULAR NEUROBIOLOGY (2015)
Postmortem findings in a case of variant Creutzfeldt-Jakob disease treated with intraventricular pentosan polysulfate
P. K. Newman et al.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2014)
Doxycycline in Creutzfeldt-Jakob disease: a phase 2, randomised, double-blind, placebo-controlled trial
Stephane Haik et al.
LANCET NEUROLOGY (2014)
Overexpression of p62/SQSTM1 promotes the degradations of abnormally accumulated PrP mutants in cytoplasm and relieves the associated cytotoxicities via autophagy-lysosome-dependent way
Yin Xu et al.
MEDICAL MICROBIOLOGY AND IMMUNOLOGY (2014)
Variant CJD 18 years of research and surveillance
Abigail B. Diack et al.
PRION (2014)
Increased expression of p62/SQSTM1 in prion diseases and its association with pathogenic prion protein
Takujiro Homma et al.
SCIENTIFIC REPORTS (2014)
New Molecules and Old Drugs as Emerging Approaches to Selectively Target Human Glioblastoma Cancer Stem Cells
Roberto Wuerth et al.
BIOMED RESEARCH INTERNATIONAL (2014)
FK506 reduces abnormal prion protein through the activation of autolysosomal degradation and prolongs survival in prion-infected mice
Takehiro Nakagaki et al.
AUTOPHAGY (2013)
Endocytosis and autophagy: Shared machinery for degradation
Christopher A. Lamb et al.
BIOESSAYS (2013)
The role of autophagy in neurodegenerative disease
Ralph A. Nixon
NATURE MEDICINE (2013)
Quinacrine treatment trial for sporadic Creutzfeldt-Jakob disease
Michael D. Geschwind et al.
NEUROLOGY (2013)
Excitotoxicity Through NMDA Receptors Mediates Cerebellar Granule Neuron Apoptosis Induced by Prion Protein 90-231 Fragment
Stefano Thellung et al.
NEUROTOXICITY RESEARCH (2013)
Unique drug screening approach for prion diseases identifies tacrolimus and astemizole as antiprion agents
Yervand Eduard Karapetyan et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
Role of Prion Protein Aggregation in Neurotoxicity
Alessandro Corsaro et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2012)
Rapamycin Delays Disease Onset and Prevents PrP Plaque Deposition in a Mouse Model of Gerstmann-Straussler-Scheinker Disease
Constanza J. Cortes et al.
JOURNAL OF NEUROSCIENCE (2012)
Exosomes: vehicles for the transfer of toxic proteins associated with neurodegenerative diseases?
Shayne A. Bellingham et al.
FRONTIERS IN PHYSIOLOGY (2012)
Misfolded PrP impairs the UPS by interaction with the 20S proteasome and inhibition of substrate entry
Pelagia Deriziotis et al.
EMBO JOURNAL (2011)
High hydrophobic amino acid exposure is responsible of the neurotoxic effects induced by E200K or D202N disease-related mutations of the human prion protein
Alessandro Corsaro et al.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2011)
Fighting neurodegeneration with rapamycin: mechanistic insights
Jordi Bove et al.
NATURE REVIEWS NEUROSCIENCE (2011)
Efficacy of Novel Acridine Derivatives in the Inhibition of hPrP90-231 Prion Protein Fragment Toxicity
Valentina Villa et al.
NEUROTOXICITY RESEARCH (2011)
Expression of Mutant or Cytosolic PrP in Transgenic Mice and Cells Is Not Associated with Endoplasmic Reticulum Stress or Proteasome Dysfunction
Elena Quaglio et al.
PLOS ONE (2011)
Autophagy Contributes to Widespread Neuronal Degeneration in Hamsters Infected with the Echigo-1 Strain of Creutzfeldt-Jakob Disease and Mice Infected with the Fujisaki Strain of Gerstmann-Straaussler-Scheinker (GSS) Syndrome
Pawel P. Liberski et al.
ULTRASTRUCTURAL PATHOLOGY (2011)
Human PrP90-231-induced cell death is associated with intracellular accumulation of insoluble and protease-resistant macroaggregates and lysosomal dysfunction
S. Thellung et al.
CELL DEATH & DISEASE (2011)
Changes in HSP gene and protein expression in natural scrapie with brain damage
Carmen Serrano et al.
VETERINARY RESEARCH (2011)
Expression of Polyubiquitin and Heat-Shock Protein 70 Genes Increases in the Later Stages of Disease Progression in Scrapie-Infected Mouse Brain
Nigel Kenward et al.
JOURNAL OF NEUROCHEMISTRY (2010)
Interplay Between 20S Proteasomes and Prion Proteins in Scrapie Disease
Manila Amici et al.
JOURNAL OF NEUROSCIENCE RESEARCH (2010)
Trehalose ameliorates dopaminergic and tau pathology in parkin deleted/tau overexpressing mice through autophagy activation
Jose A. Rodriguez-Navarro et al.
NEUROBIOLOGY OF DISEASE (2010)
Ultrastructural Characteristics (or Evaluation) of Creutzfeldt-Jakob Disease and Other Human Transmissible Spongiform Encephalopathies or Prion Diseases
Pawel P. Liberski et al.
ULTRASTRUCTURAL PATHOLOGY (2010)
The ubiquitin proteasome system in neuropathology
Norman L. Lehman
ACTA NEUROPATHOLOGICA (2009)
Autophagy induction by trehalose counteracts cellular prion infection
Yasmine Aguib et al.
AUTOPHAGY (2009)
Lithium induces clearance of protease resistant prion protein in prion-infected cells by induction of autophagy
Andreas Heiseke et al.
JOURNAL OF NEUROCHEMISTRY (2009)
Ultrastructural study of florid plaques in variant Creutzfeldt-Jakob disease: a comparison with amyloid plaques in kuru, sporadic Creutzfeldt-Jakob disease and Gerstmann-Straussler-Scheinker disease
B. Sikorska et al.
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY (2009)
Dual Modulation of ERK1/2 and p38 MAP Kinase Activities Induced by Minocycline Reverses the Neurotoxic Effects of the Prion Protein Fragment 90-231
Alessandro Corsaro et al.
NEUROTOXICITY RESEARCH (2009)
Germline P Granules Are Liquid Droplets That Localize by Controlled Dissolution/Condensation
Clifford P. Brangwynne et al.
SCIENCE (2009)
Trehalose impairs aggregation of PrPSc molecules and protects prion-infected cells against oxidative damage
Florence Beranger et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2008)
Dysfunction of the ubiquitin-proteasome system in multiple disease conditions: therapeutic approaches
Subhankar Paul
BIOESSAYS (2008)
Amyloid peptides in different assembly states and related effects on isolated and cellular proteasomes
Valentina Cecarini et al.
BRAIN RESEARCH (2008)
Autophagy induction and autophagosome clearance in neurons: Relationship to autophagic pathology in Alzheimer's disease
Barry Boland et al.
JOURNAL OF NEUROSCIENCE (2008)
Aβ inhibits the proteasome and enhances amyloid and tau accumulation
Bertrand P. Tseng et al.
NEUROBIOLOGY OF AGING (2008)
The Efficacy of Tetracyclines in Peripheral and Intracerebral Prion Infection
Ada De Luigi et al.
PLOS ONE (2008)
Heat shock factor 1 regulates lifespan as distinct from disease onset in prion disease
Andrew D. Steele et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Induction of autophagy promotes fusion of multivesicular bodies with autophagic vacuoles in K562 cells
Claudio M. Fader et al.
TRAFFIC (2008)
Intracellular accumulation of a mild-denatured monomer of the human PrP fragment 90-231, as possible mechanism of its neurotoxic effects
Katia Chiovitti et al.
JOURNAL OF NEUROCHEMISTRY (2007)
p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy
Serhiy Pankiv et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
In vitro and in vivo neurotoxicity of prion protein oligomers
Steve Simoneau et al.
PLOS PATHOGENS (2007)
Disease-associated prion protein oligomers inhibit the 26S proteasome
Mark Kristiansen et al.
MOLECULAR CELL (2007)
Trehalose, a novel mTOR-independent autophagy enhancer, accelerates the clearance of mutant huntingtin and α-synuclein
Sovan Sarkar et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Packaging of prions into exosomes is associated with a novel pathway of PrP processing
L. J. Vella et al.
JOURNAL OF PATHOLOGY (2007)
Potential therapeutic applications of autophagy
David C. Rubinsztein et al.
NATURE REVIEWS DRUG DISCOVERY (2007)
Potential compensatory responses through autophagic/lysosomal pathways in Neurodegenerative diseases
David Butler et al.
AUTOPHAGY (2006)
Inositol and IP3 levels regulate autophagy - Biology and therapeutic speculations
Sovan Sarkar et al.
AUTOPHAGY (2006)
Conformation dependent pro-apoptotic activity of the recombinant human prion protein fragment 90-231
A. Corsaro et al.
INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY (2006)
The battle of the fold: chaperones take on prions
HL True
TRENDS IN GENETICS (2006)
p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death
G Bjorkoy et al.
JOURNAL OF CELL BIOLOGY (2005)
Trehalose differentially inhibits aggregation and neurotoxicity of beta-amyloid 40 and 42
R Liu et al.
NEUROBIOLOGY OF DISEASE (2005)
Novel insights into the mechanism of chaperone-assisted protein disaggregation
J Weibezahn et al.
BIOLOGICAL CHEMISTRY (2005)
Prion protein is ubiquitinated after developing protease resistance in the brains of scrapie-infected mice
SC Kang et al.
JOURNAL OF PATHOLOGY (2004)
Treatment of transmissible spongiform encephalopathy by intraventricular drug infusion in animal models
K Doh-Ura et al.
JOURNAL OF VIROLOGY (2004)
Doxycycline and protein folding agents rescue the abnormal phenotype of familial CJD H187R in a cell model
YP Gu et al.
MOLECULAR BRAIN RESEARCH (2004)
Proteasomal inhibition by α-synuclein filaments and oligomers
E Lindersson et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Efficacy of flupirtine on cognitive function in patients with CJD - A double-blind study
M Otto et al.
NEUROLOGY (2004)
Trehalose alleviates polyglutamine-mediated pathology in a mouse model of Huntington disease
M Tanaka et al.
NATURE MEDICINE (2004)
Autophagy is a part of ultrastructural synaptic pathology in Creutzfeldt-Jakob disease : a brain biopsy study
B Sikorska et al.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2004)
Cells release prions in association with exosomes
B Fevrier et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Stages in the development of Parkinson's disease-related pathology
H Braak et al.
CELL AND TISSUE RESEARCH (2004)
Subclinical prion infection
AF Hill et al.
TRENDS IN MICROBIOLOGY (2003)
The ubiquitin proteasome system in neurodegenerative diseases: Sometimes the chicken, sometimes the egg
A Ciechanover et al.
NEURON (2003)
Prion protein trafficking and the development of neurodegeneration
RS Hegde et al.
TRENDS IN NEUROSCIENCES (2003)
Aggresome formation by mutant prion proteins: The unfolding role of proteasomes in familial prion disorders
Ravi Shankar Mishra et al.
JOURNAL OF ALZHEIMERS DISEASE (2003)
Impairment of proteasome structure and function in aging
G Carrard et al.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2002)
Aggregate formation inhibits proteasomal degradation of polyglutamine proteins
LGGC Verhoef et al.
HUMAN MOLECULAR GENETICS (2002)
Tetracyclines affect prion infectivity
G Forloni et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
Inherent toxicity of aggregates implies a common mechanism for protein misfolding diseases
M Bucciantini et al.
NATURE (2002)
The ubiquitin-proteasome proteolytic pathway: Destruction for the sake of construction
MH Glickman et al.
PHYSIOLOGICAL REVIEWS (2002)
Wild-type PrP and a mutant associated with prion disease are subject to retrograde transport and proteasome degradation
JY Ma et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
Role of AMP-activated protein kinase in mechanism of metformin action
GC Zhou et al.
JOURNAL OF CLINICAL INVESTIGATION (2001)
Proteasomes and ubiquitin are involved in the turnover of the wild-type prion protein
Y Yedidia et al.
EMBO JOURNAL (2001)
Prominent stress response of Purkinje cells in Creutzfeldt-Jakob disease
GG Kovács et al.
NEUROBIOLOGY OF DISEASE (2001)
Ubiquitin enters the new millennium
CM Pickart
MOLECULAR CELL (2001)
Distinct functional surface regions on ubiquitin
KE Sloper-Mould et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Impairment of the ubiquitin-proteasome system by protein aggregation
NF Bence et al.
SCIENCE (2001)
A transmembrane form of the prion protein contains an uncleaved signal peptide and is retained in the endoplasmic reticululm
RS Stewart et al.
MOLECULAR BIOLOGY OF THE CELL (2001)
Conformational propagation with prion-like characteristics in a simple model of protein folding
PM Harrison et al.
PROTEIN SCIENCE (2001)
Human platelets loaded with trehalose survive freeze-drying
WF Wolkers et al.
CRYOBIOLOGY (2001)
The chaperone protein BiP binds to a mutant prion protein and mediates its degradation by the proteasome
TC Jin et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Aggresomes, inclusion bodies and protein aggregation
RR Kopito
TRENDS IN CELL BIOLOGY (2000)
PrPC expression in the peripheral nervous system is a determinant of prion neuroinvasion
M Glatzel et al.
JOURNAL OF GENERAL VIROLOGY (2000)
Effect of the E200K mutation on prion protein metabolism - Comparative study of a cell model and human brain
S Capellari et al.
AMERICAN JOURNAL OF PATHOLOGY (2000)
Impaired proteasome function in Alzheimer's disease
JN Keller et al.
JOURNAL OF NEUROCHEMISTRY (2000)
Accumulation of protease-resistant prion protein (PrP) and apoptosis of cerebellar granule cells in transgenic mice expressing a PrP insertional mutation
R Chiesa et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)