期刊
FRONTIERS IN MOLECULAR NEUROSCIENCE
卷 15, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fnmol.2022.817738
关键词
acupuncture; TRPV channels; autonomic nervous system; central nervous system; peripheral sensory nervous
资金
- National Natural Science Foundation of China
- Traditional Chinese Medicine Scientific Research Project of Hubei Provincial Health Commission
- Wuhan Medical Research Project
- [81774420]
- [81774401]
- [82105009]
- [82274634]
- [ZY2021Q031]
- [WX19Y18]
- [WZ22Q32]
This article discusses the relationship between acupuncture and TRPV channels and finds that acupuncture stimulation has a significant modulation effect on TRPV1 and TRPV4. However, the regulation of TRPV channels differs at different anatomical levels.
Acupuncture is a common complementary and alternative therapy around the world, but its mechanism remains still unclear. In the past decade, some studies indicated that transient receptor potential vanilloid (TRPV) channels play a great role in the response of acupuncture stimulation. In this article, we discussed the relationship between acupuncture and TRPV channels. Different from inhibitors and agonists, the regulation of acupuncture on TRPV channels is multi-targeted and biphasic control. Acupuncture stimulation shows significant modulation on TRPV1 and TRPV4 at the autonomic nervous system (ANS) including central and peripheral nervous systems. On the contrary, the abundant expression and functional participation of TRPV1 and TRPV4 were specific to acupuncture stimulation at acupoints. The enhancement or inhibition of TRPV channels at different anatomical levels will affect the therapeutic effect of acupuncture. In conclusion, TRPV channels help to understand the principle of acupuncture stimulation, and acupuncture also provides a potential approach to TRPV-related trials.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据