期刊
FRONTIERS IN MOLECULAR NEUROSCIENCE
卷 15, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fnmol.2022.1017568
关键词
Wnt/beta-catenin; Wnt/PCP; WNT/calcium; neural progenitor cells; neurogenesis; glioma; glioblastoma therapy
资金
- Qatar National Research Fund (QNRF) [NPRP14S-0404-21014]
- FRS-FNRS [PDR T00075.15, PDR T0236.20, EOS 30913351]
- JED Foundation
- Reine Elisabeth Medical Foundation (FMRE)
Neurogenesis and tumorigenesis share common signaling molecules and pathways involved in cell proliferation, differentiation, migration, and death. Abnormalities in these molecular mechanisms can lead to tumor formation and progression.
Neurogenesis and tumorigenesis share signaling molecules/pathways involved in cell proliferation, differentiation, migration, and death. Self-renewal of neural stem cells is a tightly regulated process that secures the accuracy of cell division and eliminates cells that undergo mitotic errors. Abnormalities in the molecular mechanisms controlling this process can trigger aneuploidy and genome instability, leading to neoplastic transformation. Mutations that affect cell adhesion, polarity, or migration enhance the invasive potential and favor the progression of tumors. Here, we review recent evidence of the WNT pathway's involvement in both neurogenesis and tumorigenesis and discuss the experimental progress on therapeutic opportunities targeting components of this pathway.
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