期刊
FRONTIERS IN MOLECULAR NEUROSCIENCE
卷 15, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fnmol.2022.958797
关键词
neurotrophic factor; trophic factor; molecular structure; antidepressant; receptor signaling
资金
- U.S. Public Health Service (National Institutes of Health) [MH106640]
- University of South Dakota Center for Brain and Behavioral Research
Antidepressants regulate neurotrophic factors and these factors themselves can produce antidepressant-like effects independently. In addition to brain derived neurotrophic factor (BDNF), there are other structurally diverse trophic factors that have similar behavioral effects. Furthermore, erythropoietin, traditionally used as a hormone for treating anemia, has been found to function as a neurotrophic factor in the central nervous system.
A significant body of research has demonstrated that antidepressants regulate neurotrophic factors and that neurotrophins themselves are capable of independently producing antidepressant-like effects. While brain derived neurotrophic factor (BDNF) remains the best studied molecule in this context, there are several structurally diverse trophic factors that have shown comparable behavioral effects, including basic fibroblast growth factor (FGF-2), insulin-like growth factor 1 (IGF-1) and vascular endothelial growth factor (VEGF). In this review we discuss the structural and biochemical signaling aspects of these neurotrophic factors with antidepressant activity. We also include a discussion on a cytokine molecule erythropoietin (EPO), widely known and prescribed as a hormone to treat anemia but has recently been shown to function as a neurotrophic factor in the central nervous system (CNS).
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