期刊
EXPERT REVIEW OF CLINICAL PHARMACOLOGY
卷 15, 期 12, 页码 1383-1397出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/17512433.2022.2142114
关键词
Medicinal cannabis; cannabidiol; pharmacokinetics; drug interactions; review
资金
- National Health and Medical Research Council's Centres of Research Excellence Program
- NSW Health's Clinical Cannabis Medicines Program
This article aims to determine the dose range at which clinically relevant cannabidiol drug interactions are likely to occur and provide clinical guidance. Although there are limitations in specific dose-response data and individual pharmacokinetic profiles for individual patients, clinicians should have an understanding of cannabinoid pharmacology and engage in clinical and therapeutic drug monitoring.
Introduction In light of the widespread use of non-prescribed and prescribed cannabidiol, the use of cannabidiol with other medications is likely, and this may result in drug interactions. Areas covered We aimed to ascertain if clinical guidance could be provided on the dose range at which cannabidiol drug interactions are likely to occur with concurrently prescribed medicines. Literature searches were conducted in Embase, MEDLINE, and PubMed from database inception to January 2022 using Emtree and MeSH terms. Reference list screening yielded further studies. Using currently available data, likely drug interactions of which prescribers of cannabidiol need to be aware, at the doses likely to cause clinically significant interactions, and drug dosing changes that may be needed are highlighted. Expert opinion We have provided an overview of evidence-based pharmacokinetic predictions and general guidance about the dose range at which clinically relevant cannabidiol drug interactions are likely. For an individual patient, there are inherent limitations in providing clinical guidance due to gaps in specific drug dose-response data and knowledge of individual pharmacokinetic profiles, including different co-morbidities, and concurrent medicines. Clinician awareness of cannabinoid pharmacology, along with clinical and therapeutic drug monitoring, are current best practice approaches to manage cannabinoid drug interactions.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据