A case of human infection by H3N8 influenza virus

Letter Infectious Diseases

Wild bird-origin H3N8 avian influenza virus exhibit well adaptation in mammalian host

Yitao Li et al.

JOURNAL OF INFECTION (2022)

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Letter Infectious Diseases

A child with acute respiratory distress syndrome caused by avian influenza H3N8 virus

Dongliang Cheng et al.

JOURNAL OF INFECTION (2022)

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Letter Medicine, General & Internal

Human Infection with an Avian-Origin Influenza A (H10N3) Virus

Xian Qi et al.

NEW ENGLAND JOURNAL OF MEDICINE (2022)

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Article Multidisciplinary Sciences

Rare variant MX1 alleles increase human susceptibility to zoonotic H7N9 influenza virus

Yongkun Chen et al.

Summary: Research shows a strong association between rare variants in the MX1 gene and H7N9 infection in humans. The identified MxA protein variants lost the ability to inhibit avian IAVs, exerting a dominant-negative effect on wild-type MxA's antiviral function, possibly leading to an MxA null phenotype in heterozygous carriers. This study provides genetic evidence for the crucial role of MX1-based antiviral defense in controlling zoonotic IAV infections in humans.

SCIENCE (2021)

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Article Multidisciplinary Sciences

Etiological and epidemiological features of acute respiratory infections in China

Zhong-Jie Li et al.

Summary: A nationwide prospective surveillance in China from 2009 to 2019 revealed that children under 5 and school-age children have the highest viral and bacterial positivity rates, with influenza virus being the most common viral pathogen and Streptococcus pneumoniae being the most common bacterial pathogen. This study emphasizes the importance of differential priorities for diagnosis, prevention, and control of acute respiratory tract infections based on patients' demographics, geographic locations, and seasonal variations in China.

NATURE COMMUNICATIONS (2021)

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Article Medicine, General & Internal