期刊
CATALYSTS
卷 12, 期 10, 页码 -出版社
MDPI
DOI: 10.3390/catal12101265
关键词
enzymatic synthesis; cinnamamides; continuous-flow reaction technology; continuous-flow microreactor; ammonolysis reaction
资金
- Natural Science Foundation of Zhejiang Province [LGN20C200020, KYYHX-20211096]
- Key Research & Development Projects of Zhejiang Province [2020C03090]
- Zhejiang Provincial Key Discipline of Chemistry Biology
- National Science and Technology Support Project [2015BAD14B0305]
- National Natural Science Foundation of China [21306172]
- Science and Technology Research Program of Zhejiang Province [2014C32094]
- Natural Science Foundation of Zhejiang University of Technology [116004029]
A highly efficient method for the synthesis of cinnamamides catalyzed by Lipozyme (R) TL IM in continuous-flow microreactors was developed. The method offers short residence time, mild reaction conditions, easy control of the reaction process, and the possibility of catalyst recycling.
While a few derivatives of cinnamamides exhibited anti-inflammatory and/ or analgesic activity, in this study, we developed a highly efficient method for the synthesis of cinnamamides from methyl cinnamates and phenylethylamines catalyzed by Lipozyme (R) TL IM in continuous-flow microreactors. The reaction parameters and broad substrate range of the new method was studied. Maximum conversion (91.3%) was obtained under the optimal condition of substrate molar ratio of 1:2 (methyl 4-chlorocinnamate: phenylethylamine) at 45 degrees C for about 40 min. The remarkable features of this work include short residence time, mild reaction conditions, easy control of the reaction process, and that the catalyst can be recycled or reused, which provide a rapid and economical strategy for the synthesis and design of cinnamamide derivatives for further research on drug activity.
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