Bacteriophobic Zwitterionic/Dopamine Coatings for Medical Elastomers

Despite modern advancements in sterilization and medical practices, bacterial infections remain a significant concern in the implantation of medical devices. There is currently an urgent need for long-lasting and high-stable strategies to avoid the adhesion of bacteria to the wide range of materials present in medical devices. Here, a versatile methodology to create anti-biofouling coatings that prevent the adhesion of bacteria to silicone-based materials used in healthcare is reported. These coatings consist of bifunctional ethylene glycol dimethacrylate as an anchor between a zwitterionic polymer (SBMA), which provides antifouling properties, and a polydopamine layer that operates as an interfacial binder, providing mechanical strength and strong adhesion to elastomeric substrates. The coatings exhibit superhydrophilic and anti-biofouling properties, creating a strong bacteriophobic effect that leads to a >99% reduction in bacterial adhesion. This bacteriophobic coating is successfully implemented and validated in a commercial urinary catheter, reducing bacterial adhesion by 1-2 orders of magnitude and avoiding bacterial colonization to prevent catheter-associated urinary tract infections. The results presented here demonstrate the versatility, durability, and scalability of the coating methodology for preventing bacterial adhesion in silicone elastomers, which can be easily applied to other elastomeric materials used in medical devices beyond urinary tract infection prevention.

Automated summary

This study introduces a versatile methodology for creating anti-biofouling coatings on medical devices, specifically silicone-based materials. The coatings consist of a functional anchor, a zwitterionic polymer, and a polydopamine layer, providing superhydrophilic and anti-biofouling properties. The results demonstrate significant reduction in bacterial adhesion, making it a promising strategy for preventing bacterial infections in healthcare settings.