期刊
ADVANCED MATERIALS INTERFACES
卷 9, 期 27, 页码 -出版社
WILEY
DOI: 10.1002/admi.202201029
关键词
field-effect transistors; phenylboronic acid; polyaniline; serotonin
资金
- Program on Open Innovation Platform with Enterprises, Research Institute and Academia (OPERA) of Japan Science and Technology (JST)
This study proposes a biosensor interface that enhances analyte signal and reduces noise in a potentiometric biosensor. The incorporation of gold nanoparticles increases signal intensity in serotonin sensing, while the structure of the biosensor reduces interfering noise.
Reduction of nonspecific signals (noise) in electrochemical biosensors is important for the realization of enzyme-free, point-of-care (POC) diagnostic devices. In this study, a simple biosensor interface that simultaneously realizes analyte signal enhancement and noise reduction to increase signal-to-noise ratio in a field-effect transistor-based potentiometric biosensor is proposed. As a proof-of-concept, a phytic-acid-doped self-functionalized polyaniline (pAni)-based nanostructure is designed. It is shown that the incorporation of gold nanoparticles in the nanostructure increases the signal intensity in serotonin sensing. Moreover, the phenylboronic acid moiety in the pAni backbone and porous nanostructure of the pAni nanostructure reduces the interfering noise generated by catecholamines and human serum albumin. It is believed that this study will contribute to the realization of versatile and multiplexed POC diagnostic devices in the future.
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