期刊
SUSTAINABILITY
卷 14, 期 20, 页码 -出版社
MDPI
DOI: 10.3390/su142013481
关键词
atomic force microscopy (AFM); bioaccessibility; cytotoxicity; inductively coupled plasma (ICP); scanning electron microscopy (SEM); transmission electron microscopy (TEM); X-ray diffraction (XRD); X-ray fluorescence (XRF)
资金
- One Asia Foundation
- Nazarbayev University
This review aims to comprehensively assess the toxicity and composition of particle-bound pollutants, evaluate different methods for characterizing particles, and provide recommendations for enhancing human health risk assessment. The study found that the cellular response to particles is complex and requires a combination of morphological and chemical data for a comprehensive assessment. The recommended method for single-particle analysis is SEM-EDS, followed by dry or wet chemical analysis techniques for studying the bulk chemistry of particles. Using bioaccessible/soluble fractions can improve the accuracy of human health risk assessment.
Particle-bound pollutants are a critical risk factor for human respiratory/cardiovascular conditions. A comprehensive analysis of the physicochemical characteristics of PM is often challenging since it requires combining different practical methods with a good understanding the of characterization outputs. The present review aims to (1) provide a comprehensive assessment of the underlying mechanisms of PM cytotoxicity and the related biological response; (2) evaluate the selected methods for PM characterization in terms of outputs, technical aspects, challenges, and sample preparation; (3) present effective means of studying PM physicochemical toxicity and composition; and (4) provide recommendations for enhancing the human health risk assessment. The cellular response to potentially toxic elements in PM is complex to understand as exposure includes systemic inflammation, increased ROS accumulation, and oxidative stress. A comprehensive toxicity assessment requires blending morphological features and chemical composition data. For the morphological/chemical characterization, we recommend first using SEM-EDS as a practical method for the single-particle analysis. Then, the bulk chemistry of PM can be further studied using either a dry analysis (e.g., XRF) or wet analysis techniques (e.g., ICP and IC). Finally, when used on a need basis, the reviewed complementary laboratory methods may further add valuable information to the characterization. The accuracy of the human health risk assessment may be improved using bioaccessible/soluble fractions of the contaminants instead of the total contaminant concentration. Having an integrated understanding of the covered analytical methods along with the health risk assessment guidelines would contribute to research on atmospheric chemistry, molecular biology, and public health while helping researchers better characterize human exposure to PM and the associated adverse health effects.
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