Different routes and forms of uterotonics for treatment of retained placenta: a randomized clinical trial

Objectives: To compare between three different uterotonics (oxytocin, carbetocin and misoprostol) given via three different routes (intraumbilical, intravenous and sublingual, respectively) in reducing the need for manual removal of placenta (MROP).Methods: A randomized trial for cases with retained placenta 30min following vaginal delivery. They received intraumbilical oxytocin, intravenous carbetocin or sublingual misoprostol. Main outcome measures were delivery of the placenta within 30min following drug administration, and need for MROP. Secondary outcome measures were injection to placental delivery time, post-delivery hemoglobin, need for blood transfusion or additional uterotonics.Results: The overall success rate was 66.7% (64/96), 71.3% (67/94) and 63.7% (58/91) for oxytocin, carbetocin and misoprostol groups, respectively (p>0.05). When time needed to achieve placental delivery considered, a significant difference was observed with the shortest time for carbetocin (16.613.76min), then oxytocin (18.28 +/- 3.34min) and lastly misoprostol (23.00 +/- 3.38min) (p<0.001). Again, carbetocin group needed less additional uterotonics to achieve adequate uterine contractions (p<0.001).Conclusions: Although we aimed to exploit the advantage of certain drug over another, all seemed to have close efficacy but it would be important that further research should highlight availability, cost, ease of administration and storage requirements to determine which agent would best be used in this clinical scenario.