期刊
NANO ENERGY
卷 100, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.nanoen.2022.107483
关键词
MWCNT membrane; Rotating magnetic field; Nearly 100% neurons; Electromagnetic induction nanogenerator; Wireless electric stimulation
类别
资金
- Project of 20 items of University of Jinan [2018GXRC031]
- National Natural Science Foundation of China [51972148]
- Major Scientific and Technological Innovation Project of Shandong Province [2021CXGC010603]
- Major Innovation Projects in Shandong Province [2018YFJH0503]
- Natural Science Foundation of Shandong Province [ZR2020KE056]
- China Scholarship Council [201808370188]
This study established a wireless triggered local electrical stimulation system to induce neuronal differentiation from rat bone-marrow-derived MSCs by using a highly conductive and flexible multi-wall carbon nanotube membrane combined with a rotating magnetic field. The system successfully generated well-differentiated neurons without nerve-inducing factors and showed promising effects in the treatment of neurodegenerative diseases.
Transdifferentiation of mesenchymal stem cells (MSCs) into neurons provides a practical way for neurodegenerative diseases as alternatives to neural stem cells, but is confronted with challenges to get well-differentiated and mature neurons. In this work, a wirelessly triggered local electrical stimulation system was established to specifically induce neuronal differentiation from rat bone-marrow-derived MSCs (rBMSCs) by coupling a highly conductive and flexible multi-wall carbon nanotube (MWCNT) membrane with a rotating magnetic field. Without nerve-inducing factors, a nearly 100% yield of differentiated neurons was realised without the presence of astrocyte cells by the localized electrical stimuli mediated from electromagnetic induction nanogenerator. Neuronal functions were revealed by rapid spontaneous [Ca2+] i-transient peaks under neurotransmitter action. This novel therapeutic strategy for neurodegenerative disease was further demonstrated in vivo, where the successful neural differentiation of exogenous rBMSCs driven by external magnetic-filed accelerated the brain recovery. This wireless electric stimulation system shows promising effects on neuron differentiation and offers a new perspective in nerve repair without glial scarring.
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