期刊
JOURNAL OF NANOBIOTECHNOLOGY
卷 20, 期 1, 页码 -出版社
BMC
DOI: 10.1186/s12951-022-01610-7
关键词
Brain tumor; Glioma; Glioblastoma; Blood-brain barrier; Invasive and non-invasive methods; Targeting vectors; Nanocarriers; Viral-like particles; Therapeutic drugs; Cell-based vehicles; Cell therapy
资金
- Ministry of Science and Higher Education of the Russian Federation [075-15-2022-311]
- Russian Science Foundation [22-75-10011]
Despite the broad development of nanotechnological approaches for cancer diagnosis and therapy, there has been no significant progress in the treatment of brain tumors. The key challenge lies in finding therapeutic molecules that can cross the blood-brain barrier and effectively target brain tumors. Various methods and nanocarriers have been explored, but clinical translations have been lacking. Understanding the mechanisms of blood-brain barrier penetration and developing advanced drug delivery platforms are crucial for the development of effective therapy against brain tumors.
Besides the broad development of nanotechnological approaches for cancer diagnosis and therapy, currently, there is no significant progress in the treatment of different types of brain tumors. Therapeutic molecules crossing the blood-brain barrier (BBB) and reaching an appropriate targeting ability remain the key challenges. Many invasive and non-invasive methods, and various types of nanocarriers and their hybrids have been widely explored for brain tumor treatment. However, unfortunately, no crucial clinical translations were observed to date. In particular, chemotherapy and surgery remain the main methods for the therapy of brain tumors. Exploring the mechanisms of the BBB penetration in detail and investigating advanced drug delivery platforms are the key factors that could bring us closer to understanding the development of effective therapy against brain tumors. In this review, we discuss the most relevant aspects of the BBB penetration mechanisms, observing both invasive and non-invasive methods of drug delivery. We also review the recent progress in the development of functional drug delivery platforms, from viruses to cell-based vehicles, for brain tumor therapy. The destructive potential of chemotherapeutic drugs delivered to the brain tumor is also considered. This review then summarizes the existing challenges and future prospects in the use of drug delivery platforms for the treatment of brain tumors.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据