☆ 4.7 Review

Advances in the modulation of ROS and transdermal administration for anti-psoriatic nanotherapies

JOURNAL OF NANOBIOTECHNOLOGY (2022)

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Review Dermatology

Macrophages in dermatology: pathogenic roles and targeted therapeutics

Drew Kuraitis et al.

Summary: The field of macrophage biology is expanding rapidly, with recent studies focusing on their pathogenic roles in dermatologic conditions like psoriasis and skin cancer. Depletion of these cells or their cytokines can lead to improved clinical outcomes, highlighting the potential for macrophage-targeted therapies in dermatology.

ARCHIVES OF DERMATOLOGICAL RESEARCH (2022)

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Review Chemistry, Multidisciplinary

Nanocarriers for Skin Applications: Where Do We Stand?

Neha Tiwari et al.

Summary: Nanosized carrier systems offer a promising alternative for improving skin penetration of therapeutic molecules with minimal damage to the skin's natural barrier. The use of nanoparticles for delivering drugs, genetic material, and vaccines into the skin is discussed, along with the importance of nanotoxicology studies and recent clinical developments in shedding light on their potential for market translation.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2022)

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Article Biotechnology & Applied Microbiology

A multifunctional composite hydrogel as an intrinsic and extrinsic coregulator for enhanced therapeutic efficacy for psoriasis

Jiangmei Xu et al.

Summary: In this study, a nanocomposite-based hydrogel was developed for the combined multiple target therapy of psoriasis by loading methotrexate (MTX) into ZnO/Ag. The results showed that the hydrogel exhibited a self-therapeutic effect and could reduce the production of innate cytokines and the secretion of adaptive cytokines in keratinocytes. In a psoriasis mice model, the hydrogel demonstrated superior transdermal delivery and enhanced therapeutic efficacy.

JOURNAL OF NANOBIOTECHNOLOGY (2022)

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Review Dermatology

International eDelphi Study to Reach Consensus on the Methotrexate Dosing Regimen in Patients With Psoriasis

Astrid M. van Huizen et al.

Summary: A global consensus on the dosing regimen of methotrexate for psoriasis patients was reached in this eDelphi study, with 20 out of 21 proposals achieving consensus, indicating the potential for a unified treatment approach with methotrexate for patients with psoriasis.

JAMA DERMATOLOGY (2022)

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Article Biochemistry & Molecular Biology

Effect of Melatonin on Psoriatic Phenotype in Human Reconstructed Skin Model

Sarah Adriana Scuderi et al.

Summary: This study investigates the effect of melatonin on psoriatic phenotype and S. aureus infection-associated psoriasis using an in vitro model. The results demonstrate that melatonin reduces histological damage, restores tight-junction expression, and reduces pro-inflammatory cytokine levels. Melatonin may have potential as a promising strategy for treating psoriasis-like skin inflammation and complications of psoriasis, such as S. aureus infection.

BIOMEDICINES (2022)

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Article Chemistry, Multidisciplinary

Topical formulation based on disease-specific nanoparticles for single-dose cure of psoriasis

Yang Mai et al.

Summary: A nanoparticle-based topical formulation called Tris-BNPs has shown promise in treating psoriasis. It has strong permeability and retention, only penetrating psoriatic skin without harming healthy skin. Tris-BNPs can slowly release corticosteroids within lesioned skin to maintain drug concentration above the therapeutic level. Compared to commercial treatments, Tris-BNPs offer better penetration and retention, and are not affected by sweating, humidity, or wiping.

JOURNAL OF CONTROLLED RELEASE (2022)

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Review Allergy

A Review of Neutrophil Extracellular Traps (NETs) in Disease: Potential Anti-NETs Therapeutics

Victoria Mutua et al.

Summary: Activated neutrophils release NETs to capture and destroy microbes, but they also cause inflammation and tissue damage. The role of NETs in autoimmune and autoinflammatory diseases is being studied, and inhibition of NETosis may reduce disease severity.

CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY (2021)

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Review Immunology

Autoinflammatory psoriasis-genetics and biology of pustular psoriasis

Ranjitha Uppala et al.

Summary: Psoriasis is a chronic inflammatory skin condition with a wide range of clinical manifestations. Genetic studies have identified six genetic variants predisposing to pustular psoriasis, with IL-36 cytokines playing a central role in disease pathophysiology.

CELLULAR & MOLECULAR IMMUNOLOGY (2021)

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Article Dermatology

Enhanced Inflammasome Activity in Patients with Psoriasis Promotes Systemic Inflammation

Deepti Verma et al.

Summary: Psoriasis patients show increased levels of IL-1 beta and IL-18 in plasma, along with elevated expression of inflammasome sensors in peripheral blood cells. TNF-alpha activates the NLRP3 inflammasome, and anti-TNF therapy can normalize inflammasome function, potentially reducing cardiovascular risk.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2021)

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Review Engineering, Biomedical

Microneedle-mediated transdermal drug delivery for treating diverse skin diseases

Dan Yang et al.

Summary: This review discusses the emergence of versatile microneedles for transdermal delivery of various drugs, especially focusing on their application in treating different skin diseases such as superficial tumors, scars, psoriasis, herpes, acne, and alopecia. It also summarizes the promises and challenges of widespread translation of microneedles for transdermal drug delivery in dermatology.

ACTA BIOMATERIALIA (2021)

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Article Engineering, Biomedical

Targeted silver nanoparticles for rheumatoid arthritis therapy via macrophage apoptosis and Re-polarization

Yihua Yang et al.

Summary: This study developed folic acid modified silver nanoparticles for targeted rheumatoid arthritis treatment by inducing M1 macrophage reduction and M2 macrophage polarization, demonstrating potent therapeutic efficacy in mice models with high biosafety.

BIOMATERIALS (2021)

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Article Biotechnology & Applied Microbiology

Catalpol ameliorates psoriasis-like phenotypes via SIRT1 mediated suppression of NF-κB and MAPKs signaling pathways

Aimin Liu et al.

Summary: This study aims to investigate the therapeutic role of catalpol in psoriasis, and the results suggest that catalpol may ameliorate psoriasis symptoms by reducing oxidative stress and inflammation, possibly through SIRT1-mediated suppression of NF-.B and MAPKs pathways.

BIOENGINEERED (2021)

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Article Chemistry, Multidisciplinary

TNFα siRNA delivery by nanoparticles and photochemical internalization for psoriasis topical therapy

Isabella Luiz Suzuki et al.

Summary: A delivery system for TNF alpha siRNA based on hybrid polymer-lipid nanoparticles was developed and successfully optimized with photochemical internalization (PCI) to decrease TNF alpha levels in a psoriasis animal model. The results demonstrate the potential of this approach for topical treatment of psoriasis.

JOURNAL OF CONTROLLED RELEASE (2021)

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Article Engineering, Biomedical

Targeting and clearance of senescent foamy macrophages and senescent endothelial cells by antibody-functionalized mesoporous silica nanoparticles for alleviating aorta atherosclerosis

Le Minh Pham et al.

Summary: This study found that CD9 antibody-modified nanoparticles showed high cellular uptake in vitro models, reducing oxidative stress and inflammation in senescent cells, and improving cell viability. In vivo experiments demonstrated that these nanoparticles effectively targeted senescent areas, delivering anti-senescence drugs to atherosclerotic plaques and alleviating the progression of atherosclerosis. This suggests a novel and precise therapeutic approach for treating atherosclerosis by targeting senescent cells.

BIOMATERIALS (2021)

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Article Chemistry, Multidisciplinary

Alkyl-Terminated Gold Nanoparticles as a Self-Therapeutic Treatment for Psoriasis

Ruifang Han et al.

Summary: The study introduces a self-therapeutic nanoparticle for the prevention and treatment of psoriasis. Results show that the nanoparticles can effectively penetrate the stratum corneum to inhibit psoriasis development and treat established psoriasis.

NANO LETTERS (2021)

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Article Dermatology

MTH1 Inhibitors for the Treatment of Psoriasis

Cecilia Bivik Eding et al.

Summary: Inflammatory diseases like psoriasis are characterized by changes in redox regulation, with increased MTH1 expression detected in affected skin. Inhibition of MTH1 can reduce psoriatic histological characteristics and normalize levels of neutrophils and T cells in the skin. Additionally, MTH1 inhibition decreases expression of T helper type 17-associated cytokines in the skin.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2021)

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Article Multidisciplinary Sciences

Skin-resident innate lymphoid cells converge on a pathogenic effector state

Piotr Bielecki et al.

Summary: This study reveals that induction of psoriasis in mice by IL-23 or imiquimod leads to a reconfiguration of skin ILCs towards a pathogenic ILC3-like state. Skin ILCs exhibit a range and flexibility in their responses, indicating that immune activities primed in healthy tissues dynamically adapt to provocations and, left unchecked, drive pathological remodelling.

NATURE (2021)

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Article Multidisciplinary Sciences

Catalytic activity tunable ceria nanoparticles prevent chemotherapy-induced acute kidney injury without interference with chemotherapeutics

Qinjie Weng et al.

Summary: Catalytic activity tunable ceria nanoparticles have been reported as potential agents for preventing chemotherapy-induced acute kidney injury without compromising the efficacy of chemotherapeutic agents. This context-dependent reactive oxygen species scavenger shows promise for clinical application in cancer patients.

NATURE COMMUNICATIONS (2021)

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Review Immunology

The Role of Natural Killer Cells in Autoimmune Diseases

Umut Can Kucuksezer et al.

Summary: NK cells are a subset of innate lymphoid cells that play important roles in anti-tumor immune responses and immune regulation, with different subgroups showing cytotoxic functions or cytokine production. Their activation is influenced by a variety of factors, including cell surface receptors and cytokines, and their dysregulation can contribute to various immune-mediated diseases. Further research on NK cell biology and their potential therapeutic applications is necessary for better understanding and treatment of inflammatory disorders.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Multidisciplinary Sciences

Microneedle-assisted genome editing: A transdermal strategy of targeting NLRP3 by CRISPR-Cas9 for synergistic therapy of inflammatory skin disorders

Tao Wan et al.

Summary: The study introduces a dissolvable microneedle patch that can deliver CRISPR-Cas9-based genome-editing agents and glucocorticoids for the treatment of inflammatory skin disorders. The microneedle releases two types of nanoformulations in the skin to exert therapeutic effects on subcutaneous inflammations.

SCIENCE ADVANCES (2021)

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Review Health Care Sciences & Services

Circulating Free DNA and Its Emerging Role in Autoimmune Diseases

Patricia Mondelo-Macia et al.

Summary: Liquid biopsies are a new way to guide therapeutic decisions in cancer by analyzing tissue-derived information such as cfDNA. Research interest in cfDNA and autoimmune diseases has recently expanded due to advancements in technology and understanding of DNA sensing receptors. The focus is on utilizing cfDNA as a biomarker in autoimmune diseases for disease activity, progression, and prediction of treatment response.

JOURNAL OF PERSONALIZED MEDICINE (2021)

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Review Immunology

SIRT1: A Potential Therapeutic Target in Autoimmune Diseases

Pan Shen et al.

Summary: SIRT1, as a member of the class III family of nicotinamide adenine dinucleotide (NAD(+))-dependent histone deacetylases, plays a crucial role in the progression of various diseases, including autoimmune diseases. Modulating the functions of SIRT1 may serve as a potential therapeutic strategy for these diseases.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Immunology

Immune Cell Infiltration Analysis Demonstrates Excessive Mast Cell Activation in Psoriasis

Yongjun Zhang et al.

Summary: Psoriatic skin shows a significant change in immune cell profiles, with an increase in activated mast cells and an almost elimination of resting mast cells. Treatment leads to a gradual restoration of resting mast cells in lesioned skin, indicating their critical role in maintaining the immune cell niche.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Biochemistry & Molecular Biology

Rapamycin Alleviates 2,3,7,8-Tetrachlorodibenzo-p-dioxin-Induced Aggravated Dermatitis in Mice with Imiquimod-Induced Psoriasis-Like Dermatitis by Inducing Autophagy

Hye Ran Kim et al.

Summary: Through mouse model experiments, we found that TCDD aggravated skin inflammation in IMQ-induced psoriatic mice, increasing the expression of AHR, CYP1A1, inflammatory cytokines, and oxidative stress markers while decreasing autophagy-related factors and antioxidant markers. Rapamycin, on the other hand, alleviated TCDD-induced skin inflammation and restored autophagy inhibition, AHR expression, oxidative stress, and inflammatory response in the psoriatic mouse model.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Allergy

Immunomodulatory aged neutrophils are augmented in blood and skin of psoriasis patients

Yessica A. Rodriguez-Rosales et al.

Summary: Patients with psoriasis exhibit a distinct neutrophil profile in circulation, with two different subsets present in psoriatic skin, including a subset resembling aged neutrophils. These aged neutrophils display suboptimal functions and induce inflammatory cytokine production by T cells through neutrophil extracellular trap formation. Targeted biological treatment may help to control sustained neutrophil-mediated inflammation.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2021)

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Article Medicine, General & Internal

The Global, Regional, and National Burden of Psoriasis: Results and Insights From the Global Burden of Disease 2019 Study

Giovanni Damiani et al.

Summary: The Global Burden of Disease study in 2019 showed that there were 4,622,594 incident cases of psoriasis worldwide in 2019, with the highest age-standardized incidence rate in high-income countries of North America and Europe. This highlights the need for objective evaluation of the disease burden to track progress at a population level.

FRONTIERS IN MEDICINE (2021)

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Review Medicine, General & Internal

Cutaneous and Systemic Psoriasis: Classifications and Classification for the Distinction

Bing-Xi Yan et al.

Summary: Psoriasis is a chronic inflammatory disease that affects approximately 0.1-1.5% of the global population, with classic skin manifestations of scaly erythematous plaques. It is often associated with comorbidities such as psoriatic arthritis, metabolic syndrome, diabetes, cardiovascular disease, nephropathy, bowel disease, and brain diseases. Classifying psoriasis as cutaneous or systemic may help in better understanding and managing the disease.

FRONTIERS IN MEDICINE (2021)

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Article Medicine, General & Internal

Acitretin Promotes the Differentiation of Myeloid-Derived Suppressor Cells in the Treatment of Psoriasis

Panpan Liu et al.

Summary: The study found that increased numbers of myeloid-derived suppressor cells (MDSCs) are involved in the development of psoriasis. Acitretin, a treatment for psoriasis, was shown to reduce the number of MDSCs and promote their differentiation into macrophages and dendritic cells. This effect was mediated by acitretin's regulation of glutathione synthesis and activation of extracellular signal-regulated kinase 1/2.

FRONTIERS IN MEDICINE (2021)

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Review Chemistry, Multidisciplinary

Functional Hydrogels as Wound Dressing to Enhance Wound Healing

Yongping Liang et al.

Summary: Hydrogels have shown promising advantages as wound dressings due to their excellent biochemical and mechanical properties. This review summarizes the advanced functions of hydrogel dressings, such as antimicrobial, adhesion, hemostasis, anti-inflammatory, substance delivery, self-healing, stimulus response, and conductivity, as well as the emerging wound monitoring feature. The potential applications for different types of wounds, including chronic wounds and focus on infected, burn, and diabetic wounds, are discussed, along with proposed future directions for hydrogel wound dressings in wound healing.

ACS NANO (2021)

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Review Chemistry, Multidisciplinary

Rational Design of Immunomodulatory Hydrogels for Chronic Wound Healing

Mahshid Kharaziha et al.

Summary: The immune reaction plays a critical role in chronic wound healing, with modulation of macrophages' polarization being an appealing approach in regenerative medicine. The use of hydrogels-based constructs has been recently developed to adjust immune cell functions in various stages of wound healing. The properties of hydrogels have significant effects on immunogenic features and the wound healing process.

ADVANCED MATERIALS (2021)

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Review Nutrition & Dietetics

Vitamin A and Vitamin E: Will the Real Antioxidant Please Stand Up?

William S. Blaner et al.

Summary: This review focuses on the mechanisms of action of vitamin A and vitamin E in the body, suggesting that vitamin A acts as an indirect antioxidant by transcriptionally regulating genes involved in antioxidant responses, while vitamin E functions as a direct antioxidant and helps prevent the increase of peroxidized lipids that affect metabolic pathways and gene expression profiles. The review also discusses the lack of compelling evidence for a direct transcriptional mechanism of vitamin E similar to that of vitamin A.

ANNUAL REVIEW OF NUTRITION, VOL 41, 2021 (2021)

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Article Engineering, Biomedical

Keratinocyte membrane-mediated nanodelivery system with dissolving microneedles for targeted therapy of skin diseases

Qian Jing et al.

Summary: The study found that epidermal cells have targeting functions and developed HaCaT cell membrane-coated pH-sensitive micelles for the treatment of skin diseases. This emerging biomimetic delivery strategy enhances the therapeutic efficacy of drugs against skin diseases. Additionally, abnormally high protein expression of Na+/K+-ATPase in diseased skin may serve as a biomarker for psoriasis.

BIOMATERIALS (2021)

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Article Engineering, Biomedical

Topical cationic hairy particles targeting cell free DNA in dermis enhance treatment of psoriasis

Yanzi Yan et al.

Summary: The study reveals that poly(2-(dimethylamino)ethyl methacrylate) (PDMA) grafted hairy silica particles (cSPs) with tunable PDMA length and particle size can effectively scavenge cfDNA in the dermis, treating psoriasis. Among them, cSPs of 700 nm diameter show excellent performance with more accumulation and longer retention in psoriatic lesions, leading to better treatment results at a lower administration frequency.

BIOMATERIALS (2021)

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Article Immunology

Glycyrrhizin improves the pathogenesis of psoriasis partially through IL-17A and the SIRT1-STAT3 axis

Huang Qiong et al.

Summary: The study showed that glycyrrhizin improved psoriasis by inhibiting the expression of IL-17A and IFN-gamma in vivo, as well as suppressing the proliferation of IL-17A-HaCaT cells and regulating STAT3 expression by upregulating SIRT1 in vitro.

BMC IMMUNOLOGY (2021)

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Article Immunology

Galangin ameliorates Imiquimod-Induced psoriasis-like skin inflammation in BALB/c mice via down regulating NF-κB and activation of Nrf2 signaling pathways

Rajendra Sangaraju et al.

Summary: The study demonstrated that galangin (GAL) has a significant protective effect on skin inflammation induced by psoriasis-like symptoms, possibly through modulation of inflammatory pathways and oxidative stress. Galangin also regulated protein levels and antioxidant markers, showing potential for treating psoriasis.

INTERNATIONAL IMMUNOPHARMACOLOGY (2021)

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Article Nanoscience & Nanotechnology

Celastrol Niosome Hydrogel Has Anti-Inflammatory Effect on Skin Keratinocytes and Circulation without Systemic Drug Exposure in Psoriasis Mice

Fen Qiu et al.

Summary: Cel Nio gel achieved the anti-psoriatic effect by inhibiting inflammation and hyperproliferation of keratinocytes in the skin, further suppressing systemic inflammation. The gel demonstrated significant local and systemic therapeutic effects in treating psoriasis.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2021)

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Review Pharmacology & Pharmacy

Microneedles-based drug delivery for the treatment of psoriasis

S. H. Shravanth et al.

Summary: This review discusses the application of microneedles as a transdermal drug delivery system for treating psoriasis, highlighting the safety and advantages of microneedle technology compared to conventional transdermal delivery systems. The article introduces different types of microneedles, discussing their characteristics, mechanisms, and drug preparation and application.

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY (2021)

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Article Materials Science, Biomaterials

Bio-hybrid hydrogel comprising collagen-capped silver nanoparticles and melatonin for accelerated tissue regeneration in skin defects

Murali Ragothaman et al.

Summary: Hydrogel-based drug delivery system shows promise in treating chronic tissue defects by inhibiting pathogenic infection and accelerating tissue regeneration. A stable bio-hybrid hydrogel system with antimicrobial, antioxidant and anti-inflammatory properties was developed. The bio-hybrid hydrogel exhibited better properties in terms of gelation, surface morphology, rheology and degelation.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2021)

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Article Engineering, Biomedical

Facile Polyphenol-Europium Assembly Enabled Functional Poly(l-Lactic Acid) Nanofiber Mats with Enhanced Antioxidation and Angiogenesis for Accelerated Wound Healing

Keke Wu et al.

Summary: A functional wound dressing was fabricated using polyphenol-europium ion assembly, showing abilities to improve wound microenvironment, scavenge ROS, and promote angiogenesis. In vitro and in vivo experiments confirmed its antioxidant properties, cell adhesion and proliferation-promoting effects, as well as angiogenesis stimulation abilities. This novel dressing holds promise for accelerated wound healing.

ADVANCED HEALTHCARE MATERIALS (2021)

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Article Chemistry, Multidisciplinary

Osteoporosis Remission and New Bone Formation with Mesoporous Silica Nanoparticles

Patricia Mora-Raimundo et al.

Summary: Nanotechnology plays a crucial role in the treatment of osteoporosis by delivering siRNA through mesoporous silica nanoparticles, promoting bone formation and improving bone microarchitecture, effectively treating osteoporosis.

ADVANCED SCIENCE (2021)

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Review Immunology

Metabolic Syndrome and Psoriasis: Mechanisms and Future Directions

Yan Hao et al.

Summary: The association between psoriasis and metabolic syndrome involves various mechanisms including endoplasmic reticulum stress, pro-inflammatory cytokine releases, excess production of reactive oxygen species, alterations in adipocytokine levels, and gut microbiota dysbiosis.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Immunology

Mitochondrial Reactive Oxygen Species Are Essential for the Development of Psoriatic Inflammation

Soichi Mizuguchi et al.

Summary: Psoriasis is an immune-mediated chronic inflammatory skin disease, with potential involvement of mitochondrial function. p32/C1qbp and mtROS may serve as therapeutic targets for psoriasis treatment.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Medicine, Research & Experimental

Clinically translatable gold nanozymes with broad spectrum antioxidant and anti-inflammatory activity for alleviating acute kidney injury

Dong-Yang Zhang et al.

Summary: A new gold nanozyme capped with NAC was developed to alleviate AKI, showing higher bioavailability and stability than NAC and significantly enhancing renal function restoration and protection against oxidative injury and inflammation in AKI mice.

THERANOSTICS (2021)

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Article Immunology

Redox regulation of immunometabolism

Jonathan Muri et al.

Summary: Immunometabolism research has revealed the significant impact of metabolic pathways and redox systems on immune cell functions, including the role of reactive oxygen species (ROS) and antioxidant pathways like thioredoxin and glutathione pathways. Studies show the central role of metabolism in determining the fate and function of immune cells, with cellular activation inducing profound changes in their oxidation-reduction system.

NATURE REVIEWS IMMUNOLOGY (2021)

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Article Dermatology

Plasma oxidation status and antioxidant capacity in psoriatic children

Tiziana Bacchetti et al.

ARCHIVES OF DERMATOLOGICAL RESEARCH (2020)

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Article Dermatology

Targeting the IL-17 Receptor Using Liposomal Spherical Nucleic Acids as Topical Therapy for Psoriasis

Haoming Liu et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2020)

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Article Cell Biology

Lysosomotropic beta blockers induce oxidative stress and IL23A production in Langerhans cells

Gerrit Mueller et al.

AUTOPHAGY (2020)

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Article Dermatology

Nanoparticle-Coupled Topical Methotrexate Can Normalize Immune Responses and Induce Tissue in Psoriasis

Alaz Ozcan et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2020)

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Article Biochemistry & Molecular Biology

Red-kerneled rice proanthocyanidin inhibits arachidonate 5-lipoxygenase and decreases psoriasis-like skin inflammation

Keisuke Toda et al.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2020)

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Article Biochemistry & Molecular Biology

Roles of mTORC1 and mTORC2 in controlling γδ T1 and γδ T17 differentiation and function

Quanli Yang et al.

CELL DEATH AND DIFFERENTIATION (2020)

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Article Biotechnology & Applied Microbiology

Polymer-stabilized Cas9 nanoparticles and modified repair templates increase genome editing efficiency

David N. Nguyen et al.

NATURE BIOTECHNOLOGY (2020)

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Article Cell Biology

Salivary Antioxidants and Oxidative Stress in Psoriatic Patients: Can Salivary Total Oxidant Status and Oxidative Status Index Be a Plaque Psoriasis Biomarker?

Anna Skutnik-Radziszewska et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2020)

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Review Biochemistry & Molecular Biology

Antioxidative and Anti-Inflammatory Properties of Cannabidiol

Sinemyiz Atalay et al.

ANTIOXIDANTS (2020)

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Article Chemistry, Multidisciplinary

Surfactant-Free, Self-Assembled Nanomicelles-Based Transdermal Hydrogel for Safe and Targeted Delivery of Methotrexate against Rheumatoid Arthritis

Maimoona Qindeel et al.

ACS NANO (2020)

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Article Biochemistry & Molecular Biology

The PDE4 inhibitor CHF6001 affects keratinocyte proliferation via cellular redox pathways

Brittany Woodby et al.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2020)

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Review Cell Biology

Role of Silent Information Regulator 1 (SIRT1) in Regulating Oxidative Stress and Inflammation

Vivek Singh et al.

INFLAMMATION (2020)

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Review Immunology

Innate Lymphocytes in Psoriasis

Barbara Polese et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Article Nanoscience & Nanotechnology

Improved Immunoregulation of Ultra-Low-Dose Silver Nanoparticle-Loaded TiO2 Nanotubes via M2 Macrophage Polarization by Regulating GLUTI and Autophagy

Yangmengfan Chen et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2020)

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Article Nanoscience & Nanotechnology

Cyclodextrin-Modified CeO2 Nanoparticles as a Multifunctional Nanozyme for Combinational Therapy of Psoriasis

Lingyun Wu et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2020)

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Review Medicine, General & Internal

Pathophysiology, Clinical Presentation, and Treatment of Psoriasis A Review

April W. Armstrong et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2020)

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Article Medicine, General & Internal

National, regional, and worldwide epidemiology of psoriasis: systematic analysis and modelling study

Rosa Parisi et al.

BMJ-BRITISH MEDICAL JOURNAL (2020)

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Article Biotechnology & Applied Microbiology

Development of erianin-loaded dendritic mesoporous silica nanospheres with pro-apoptotic effects and enhanced topical delivery

Canlong Mo et al.

JOURNAL OF NANOBIOTECHNOLOGY (2020)

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Review Chemistry, Multidisciplinary

The Impact of Engineered Silver Nanomaterials on the Immune System

Neethu Ninan et al.

NANOMATERIALS (2020)

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Reactive oxygen species (ROS) as pleiotropic physiological signalling agents

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Myeloperoxidase Modulates Inflammation in Generalized Pustular Psoriasis and Additional Rare Pustular Skin Diseases

Stefan Haskamp et al.

AMERICAN JOURNAL OF HUMAN GENETICS (2020)

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Cellular Mechanisms of NETosis

Hawa Racine Thiam et al.

Annual Review of Cell and Developmental Biology (2020)

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Article Biochemistry & Molecular Biology

Cimifugin ameliorates imiquimod-induced psoriasis by inhibiting oxidative stress and inflammation via NF-κB/MAPK pathway

Aimin Liu et al.

BIOSCIENCE REPORTS (2020)

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Article Pharmacology & Pharmacy

Therapeutic treatment with Ibrutinib attenuates imiquimod-induced psoriasis-like inflammation in mice through downregulation of oxidative and inflammatory mediators in neutrophils and dendritic cells

Naif O. Al-Harbi et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2020)

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Article Dermatology

NADPH oxidase inhibition rescues keratinocytes from elevated oxidative stress in a 2D atopic dermatitis and psoriasis model

Hila Emmert et al.

EXPERIMENTAL DERMATOLOGY (2020)

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Article Multidisciplinary Sciences

Topical nanoparticles interfering with the DNA-LL37 complex to alleviate psoriatic inflammation in mice and monkeys

Huiyi Liang et al.

SCIENCE ADVANCES (2020)

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Article Engineering, Biomedical

Multi-component clobetasol-loaded monolithic lipid-polymer hybrid nanoparticles ameliorate imiquimod-induced psoriasis-like skin inflammation in Swiss albino mice

Sudeep Sudesh Pukale et al.

ACTA BIOMATERIALIA (2020)

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Review Materials Science, Biomaterials

Silver nanoparticles: Advanced and promising technology in diabetic wound therapy

Hira Choudhury et al.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2020)

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Review Biochemistry & Molecular Biology

Role of Innate Immune Cells in Psoriasis

Yuki Sato et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Review Biochemistry & Molecular Biology

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Cannabidiol Modifies the Formation of NETs in Neutrophils of Psoriatic Patients

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Bilirubin nanomedicine alleviates psoriatic skin inflammation by reducing oxidative stress and suppressing pathogenic signaling

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Melatonin's Impact on Antioxidative and Anti-Inflammatory Reprogramming in Homeostasis and Disease

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The KEAP1/NRF2 Signaling Pathway in Keratinization

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Natural Nrf2 Modulators for Skin Protection

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Targeted Combination of Antioxidative and Anti-Inflammatory Therapy of Rheumatoid Arthritis using Multifunctional Dendrimer-Entrapped Gold Nanoparticles as a Platform

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Melatonin loaded lecithin-chitosan nanoparticles improved the wound healing in diabetic rats

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Dimethyl Fumarate Targets MSK1, RSK1, 2 and IKKα/β Kinases and Regulates NF-κB/p65 Activation in Psoriasis: A Demonstration of the Effect on Peripheral Blood Mononuclear Cells, Drawn from Two Patients with Severe Psoriasis Before and After Treatment with Dimethyl Fumarate

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Tuned Cationic Dendronized Polymer: Molecular Scavenger for Rheumatoid Arthritis Treatment

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cis-Khellactone Inhibited the Proinflammatory Macrophages via Promoting Autophagy to Ameliorate Imiquimod-Induced Psoriasis

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A systematic review of cannabidiol dosing in clinical populations

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Apremilast increases IL-10-producing regulatory B cells and decreases proinflammatory T cells and innate cells in psoriatic arthritis and psoriasis

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Adaptive and Innate Immunity in Psoriasis and Other Inflammatory Disorders

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Thermoresponsive in Situ Forming Hydrogel with Sol-Gel Irreversibility for Effective Methicillin-Resistant Staphylococcus aureus Infected Wound Healing

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Ceria Nanoparticles Meet Hepatic Ischemia-Reperfusion Injury: The Perfect Imperfection

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Increased ILC3s associated with higher levels of IL-1β aggravates inflammatory arthritis in mice lacking phagocytic NADPH oxidase

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Dimethyl fumarate alters intracellular Ca2+ handling in immune cells by redox-mediated pleiotropic effects

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Hyaluronic Acid-Based Dissolving Microneedle Patch Loaded with Methotrexate for Improved Treatment of Psoriasis

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Chemerin/ChemR23 axis triggers an inflammatory response in keratinocytes through ROS-sirt1-NF-κB signaling

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Therapeutic targeting of the NRF2 and KEAP 1 partnership in chronic diseases

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Redox imbalance and IL-17 responses in memory CD4+ T cells from patients with psoriasis

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Synergistic Oxygen Generation and Reactive Oxygen Species Scavenging by Manganese Ferrite/Ceria Co-decorated Nanoparticles for Rheumatoid Arthritis Treatment

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Histone Acetylation Promotes Neutrophil Extracellular Trap Formation

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Targeted therapy in chronic diseases using nanomaterial-based drug delivery vehicles

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Astilbin reduces ROS accumulation and VEGF expression through Nrf2 in psoriasis-like skin disease

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NATURE REVIEWS IMMUNOLOGY (2019)

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CD44 Assists the Topical Anti-Psoriatic Efficacy of Curcumin-Loaded Hyaluronan-Modified Ethosomes: A New Strategy for Clustering Drug in Inflammatory Skin

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THERANOSTICS (2019)

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Nanoparticle-Assisted Transcutaneous Delivery of a Signal Transducer and Activator of Transcription 3-Inhibiting Peptide Ameliorates Psoriasis-like Skin Inflammation

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Polymeric microneedles for transdermal protein delivery

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Custom-Made Ceria Nanoparticles Show a Neuroprotective Effect by Modulating Phenotypic Polarization of the Microglia

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Ceria Nanoparticle Systems for Selective Scavenging of Mitochondrial, Intracellular, and Extracellular Reactive Oxygen Species in Parkinson's Disease

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Dimethyl fumarate (DMF) vs. monoethyl fumarate (MEF) salts for the treatment of plaque psoriasis: a review of clinical data

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Topical silver and gold nanoparticles complexed with Cornus mas suppress inflammation in human psoriasis plaques by inhibiting NF-B activity

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Deciphering psoriasis. A bioinformatic approach

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Proanthocyanidins: novel treatment for psoriasis that reduces oxidative stress and modulates Th17 and Treg cells

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Dimethyl fumarate targets GAPDH and aerobic glycolysis to modulate immunity

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Naturally derived Heme-Oxygenase 1 inducers attenuate inflammatory responses in human dendritic cells and T cells: relevance for psoriasis treatment

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SCIENTIFIC REPORTS (2018)

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Mannan-induced Nos2 in macrophages enhances IL-17-driven psoriatic arthritis by innate lymphocytes

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SCIENCE ADVANCES (2018)

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Curcumin-loaded lipid-hybridized cellulose nanofiber film ameliorates imiquimod-induced psoriasis-like dermatitis in mice

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Application of nanoparticles in percutaneous delivery of active ingredients in cosmetic preparations

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BIOMEDICINE & PHARMACOTHERAPY (2018)

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Carbomer gel bearing methotrexate loaded lipid nanocontainers shows improved topical delivery intended for effective management of psoriasis

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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2018)

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Electrophilic properties of itaconate and derivatives regulate the I kappa B zeta-ATF3 inflammatory axis

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Review Pharmacology & Pharmacy

Novel Topical Nanocarriers for Treatment of Psoriasis: An Overview

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CURRENT PHARMACEUTICAL DESIGN (2018)

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Cationic nanoparticle as an inhibitor of cell-free DNA-induced inflammation

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NATURE COMMUNICATIONS (2018)

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Dimethyl fumarate modulates neutrophil extracellular trap formation in a glutathione- and superoxide-dependent manner

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A systematic review of worldwide epidemiology of psoriasis

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Enhanced topical penetration, system exposure and anti-psoriasis activity of two particle-sized, curcumin-loaded PLGA nanoparticles in hydrogel

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HBV inhibits LPS-induced NLRP3 inflammasome activation and IL-1β production via suppressing the NF-κB pathway and ROS production

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Nanoparticle delivery of Cas9 ribonucleoprotein and donor DNA in vivo induces homology-directed DNA repair

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Involvement of autophagy in NK cell development and function

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Pro-oxidant status and Nrf2 levels in psoriasis vulgaris skin tissues and dimethyl fumarate-treated HaCaT cells

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GPR43 activation enhances psoriasis-like inflammation through epidermal upregulation of IL-6 and dual oxidase 2 signaling in a murine model

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Direct control of regulatory I cells by keratinocytes

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Apremilast: A Review in Psoriasis and Psoriatic Arthritis

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DRUGS (2017)

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Psoriasis-Targets and Therapy (2017)

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Mitochondria-Targeting Ceria Nanoparticles as Antioxidants for Alzheimer's Disease

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ACS NANO (2016)

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Bilirubin Nanoparticles as a Nanomedicine for Anti-inflammation Therapy

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ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2016)

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Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages

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Heme oxygenase 1 controls early innate immune response of macrophages to Salmonella Typhimurium infection

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CELLULAR MICROBIOLOGY (2016)

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Neutrophil extracellular traps enriched in oxidized mitochondrial DNA are interferogenic and contribute to lupus-like disease

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NATURE MEDICINE (2016)

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Heme oxygenase-1 induction attenuates imiquimod-induced psoriasiform inflammation by negative regulation of Stat3 signaling

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SCIENTIFIC REPORTS (2016)

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Immunomodulatory Effects of Coated Gold Nanoparticles in LPS-Stimulated In Vitro and In Vivo Murine Model Systems

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CHEM (2016)

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Review Immunology

Mitochondria in the Regulation of Innate and Adaptive Immunity

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IMMUNITY (2015)

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Human mast cells are major IL-22 producers in patients with psoriasis and atopic dermatitis

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JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2015)

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Acute Activation of Oxidative Pentose Phosphate Pathway as First-Line Response to Oxidative Stress in Human Skin Cells

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MOLECULAR CELL (2015)

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Intracellular free radical production by peripheral blood T lymphocytes from patients with systemic sclerosis: role of NADPH oxidase and ERK1/2

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Aquaporin-3-mediated hydrogen peroxide transport is required for NF-κB signalling in keratinocytes and development of psoriasis

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NATURE COMMUNICATIONS (2015)

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Review Cell Biology

Heme oxygenase-1: emerging target of cancer therapy

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JOURNAL OF BIOMEDICAL SCIENCE (2015)

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Review Immunology

Immunology of Psoriasis

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ANNUAL REVIEW OF IMMUNOLOGY, VOL 32 (2014)

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Interferon-γ/CCR5 expression in invariant natural killer T cells and CCL5 expression in capillary veins of dermal papillae correlate with development of psoriasis vulgaris

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BRITISH JOURNAL OF DERMATOLOGY (2014)

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Article Dermatology

Circulating cell-free DNA levels in Portuguese patients with psoriasis vulgaris according to severity and therapy

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BRITISH JOURNAL OF DERMATOLOGY (2014)

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Article Cell Biology

Apremilast is a selective PDE4 inhibitor with regulatory effects on innate immunity

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CELLULAR SIGNALLING (2014)

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Interplay between DNA repair and inflammation, and the link to cancer

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CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY (2014)

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T cell-derived microvesicles induce mast cell production of IL-24: Relevance to inflammatory skin diseases

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JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2014)

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Editorial Material Dermatology

A New Player on the Psoriasis Block: IL-17A-and IL-22-Producing Innate Lymphoid Cells

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JOURNAL OF INVESTIGATIVE DERMATOLOGY (2014)

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Composition of Innate Lymphoid Cell Subsets in the Human Skin: Enrichment of NCR+ ILC3 in Lesional Skin and Blood of Psoriasis Patients

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JOURNAL OF INVESTIGATIVE DERMATOLOGY (2014)

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Characterization of Innate Lymphoid Cells in Human Skin and Blood Demonstrates Increase of NKp44+ILC3 in Psoriasis

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JOURNAL OF INVESTIGATIVE DERMATOLOGY (2014)

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Article Immunology

Perivascular leukocyte clusters are essential for efficient activation of effector T cells in the skin

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NATURE IMMUNOLOGY (2014)

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Article Biochemistry & Molecular Biology

Anti-inflammatory activity of compounds isolated from Astragalus sinicus L. in cytokine-induced keratinocytes and skin

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EXPERIMENTAL AND MOLECULAR MEDICINE (2014)

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A biodegradable hydrogel system containing curcumin encapsulated in micelles for cutaneous wound healing

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BIOMATERIALS (2013)

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ROS play a critical role in the differentiation of alternatively activated macrophages and the occurrence of tumor-associated macrophages

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CELL RESEARCH (2013)

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Article Immunology

Tumor Necrosis Factor Receptor Signaling in Keratinocytes Triggers Interleukin-24-Dependent Psoriasis-like Skin Inflammation in Mice

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IMMUNITY (2013)

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Article Allergy

Human mast cells drive memory CD4+ T cells toward an inflammatory IL-22+ phenotype

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JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2013)

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Review Biochemistry & Molecular Biology

Unearthing the secrets of mitochondrial ROS and glutathione in bioenergetics

Ryan J. Mailloux et al.

TRENDS IN BIOCHEMICAL SCIENCES (2013)

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Review Immunology

The IL-23/T17 pathogenic axis in psoriasis is amplified by keratinocyte responses

Michelle A. Lowes et al.

TRENDS IN IMMUNOLOGY (2013)

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Review Immunology

Innate lymphoid cells - how did we miss them?

Jennifer A. Walker et al.

NATURE REVIEWS IMMUNOLOGY (2013)

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Review Immunology

The role of dendritic cells in autoimmunity

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NATURE REVIEWS IMMUNOLOGY (2013)

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Review Chemistry, Multidisciplinary

Mesoporous Silica Nanoparticles: Synthesis, Biocompatibility and Drug Delivery

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ADVANCED MATERIALS (2012)

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Article Rheumatology

Mitochondrial mutagenesis correlates with the local inflammatory environment in arthritis

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ANNALS OF THE RHEUMATIC DISEASES (2012)

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Article Dermatology

Assessment of an imiquimod-induced psoriatic mouse model in relation to oxidative stress

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ARCHIVES OF DERMATOLOGICAL RESEARCH (2012)

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Article Engineering, Biomedical

Skin permeating nanogel for the cutaneous co-delivery of two anti-inflammatory drugs

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BIOMATERIALS (2012)

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Article Medicine, Research & Experimental

Rorγt+ innate lymphocytes and γδ T cells initiate psoriasiform plaque formation in mice

Stanislav Pantelyushin et al.

JOURNAL OF CLINICAL INVESTIGATION (2012)

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Human Keratinocytes' Response to Injury Upregulates CCL20 and Other Genes Linking Innate and Adaptive Immunity

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JOURNAL OF INVESTIGATIVE DERMATOLOGY (2012)

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Article Immunology

Pivotal Role of Dermal IL-17-Producing γδ T Cells in Skin Inflammation

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IMMUNITY (2011)

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Article Allergy

Human mast cell degranulation and preformed TNF secretion require mitochondrial translocation to exocytosis sites: Relevance to atopic dermatitis

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JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2011)

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Article Chemistry, Multidisciplinary

Topical drug delivery by a polymeric nanosphere gel: Formulation optimization and in vitro and in vivo skin distribution studies

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JOURNAL OF CONTROLLED RELEASE (2011)

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Article Immunology

Fumarates improve psoriasis and multiple sclerosis by inducing type II dendritic cells

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JOURNAL OF EXPERIMENTAL MEDICINE (2011)

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A role for mitochondria in NLRP3 inflammasome activation

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NATURE (2011)

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Review Biochemistry & Molecular Biology

The Inflammasomes

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CELL (2010)

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Review Allergy

Natural killer cells in atopic and autoimmune diseases of the skin

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JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2010)

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Article Cardiac & Cardiovascular Systems

Cannabidiol Attenuates Cardiac Dysfunction, Oxidative Stress, Fibrosis, and Inflammatory and Cell Death Signaling Pathways in Diabetic Cardiomyopathy

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JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2010)

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Aquaporin-3 mediates hydrogen peroxide uptake to regulate downstream intracellular signaling

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

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Mitochondrial Uncoupling Protein 2 Inhibits Mast Cell Activation and Reduces Histamine Content

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JOURNAL OF IMMUNOLOGY (2009)

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Review Dermatology

Treatments for psoriasis and the risk of malignancy

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Amelioration of epidermal hyperplasia by TNF inhibition is associated with reduced Th17 responses

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Glutathione depletion inhibits dendritic cell maturation and delayed-type hypersensitivity: Implications for systemic disease and immunosenescence

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Stat3 links activated keratinocytes and immunocytes required for development of psoriasis in a novel transgenic mouse model

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Calcium, ATP, and ROS: a mitochondrial love-hate triangle

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Psoriasis is mediated by a cutaneous defect triggered by activated immunocytes: Induction of psoriasis by cells with natural killer receptors

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