4.7 Article

Engineered skeletal muscle recapitulates human muscle development, regeneration and dystrophy

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Multidisciplinary Sciences

Muscle repair after physiological damage relies on nuclear migration for cellular reconstruction

William Roman et al.

Summary: The study revealed that localized muscle injuries triggered by exercise activate a myofiber self-repair mechanism that is independent of satellite cells. A signaling cascade involving calcium, Cdc42, and phosphokinase C attracts myonuclei to the damaged site, accelerating sarcomere repair and delivering messenger RNA for cellular reconstruction. Myofiber self-repair is a cell-autonomous protective mechanism, offering an alternative model for understanding muscle architecture restoration in health and disease.

SCIENCE (2021)

Article Geriatrics & Gerontology

Myogenesis modelled by human pluripotent stem cells: a multi-omic study of Duchenne myopathy early onset

Virginie Mournetas et al.

Summary: This study utilized cells from DMD patients and induced pluripotent stem cells to investigate the pathogenesis of DMD through multi-omic analysis, revealing that pathological changes of DMD start as early as the embryonic stage, suggesting a need to reconsider the role of dystrophin in muscle development.

JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE (2021)

Editorial Material Geriatrics & Gerontology

Ethical guidelines for publishing in the Journal of Cachexia, Sarcopenia and Muscle: update 2021

Stephan von Haehling et al.

Summary: This article outlines the ethical guidelines for authorship and publishing in The Journal of Cachexia, Sarcopenia and Muscle and its two daughter journals. It includes principles such as author approval, contribution, originality, approval from relevant bodies, disclosure of conflicts of interest and funding sources, and maintenance of data integrity. If any information in the manuscript changes, authors are required to promptly notify the Editor-in-Chief for updates or withdrawal.

JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE (2021)

Article Multidisciplinary Sciences

Prednisolone rescues Duchenne muscular dystrophy phenotypes in human pluripotent stem cell-derived skeletal muscle in vitro

Ziad Al Tanoury et al.

Summary: This study introduces an in vitro human model to investigate the pathology of Duchenne muscular dystrophy (DMD) and test new therapeutic approaches. The researchers describe an optimized protocol for differentiating human induced pluripotent stem cells (iPSC) to a late myogenic stage, which allows them to replicate classic DMD phenotypes in isogenic DMD-mutant iPSC lines. Treatment with prednisolone significantly improves muscle function in DMD iPSC lines, challenging the prevailing view that its benefits are solely due to anti-inflammatory properties.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

Article Cell Biology

A muscle fatigue-like contractile decline was recapitulated using skeletal myotubes from Duchenne muscular dystrophy patient-derived iPSCs

Tomoya Uchimura et al.

Summary: This study demonstrates the development of a disease model using MYOD1-induced differentiation of hiPSCs into functional skeletal myotubes, which recapitulates declines in contractile performance in dystrophic myotubes through long-term EFS training. Screening of clinically relevant drugs using this model identifies three compounds that ameliorate this decline, and the feasibility of adapting the model to a 96-well culture system using optogenetic technology for large-scale screening is validated.

CELL REPORTS MEDICINE (2021)

Article Biochemical Research Methods

Purification and preservation of satellite cells from human skeletal muscle

Katharine Striedinger et al.

Summary: This protocol offers techniques for isolating and purifying functional satellite cells from human muscle tissue, allowing for in vitro and in vivo experimentation and potential clinical applications.

STAR PROTOCOLS (2021)

Correction Cell & Tissue Engineering

Self-Organizing 3D Human Trunk Neuromuscular Organoids (vol 26, pg 172, 2020)

Jorge-Miguel Faustino Martins et al.

CELL STEM CELL (2020)

Article Biochemistry & Molecular Biology

Regeneration competent satellite cell niches in rat engineered skeletal muscle

Malte Tiburcy et al.

FASEB BIOADVANCES (2019)

Article Multidisciplinary Sciences

Engineering human pluripotent stem cells into a functional skeletal muscle tissue

Lingjun Rao et al.

NATURE COMMUNICATIONS (2018)

Article Cell Biology

In Vivo Human Somitogenesis Guides Somite Development from hPSCs

Haibin Xi et al.

CELL REPORTS (2017)

Article Biochemical Research Methods

Generation of human muscle fibers and satellite-like cells from human pluripotent stem cells in vitro

Jerome Chal et al.

NATURE PROTOCOLS (2016)

Article Cell & Tissue Engineering

A Human Pluripotent Stem Cell Model of Facioscapulohumeral Muscular Dystrophy-Affected Skeletal Muscles

Leslie Caron et al.

STEM CELLS TRANSLATIONAL MEDICINE (2016)

Article Biotechnology & Applied Microbiology

Differentiation of pluripotent stem cells to muscle fiber to model Duchenne muscular dystrophy

Jerome Chal et al.

NATURE BIOTECHNOLOGY (2015)

Article Multidisciplinary Sciences

Biomimetic engineered muscle with capacity for vascular integration and functional maturation in vivo

Mark Juhas et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Article Cell & Tissue Engineering

Derivation and Expansion of PAX7-Positive Muscle Progenitors from Human and Mouse Embryonic Stem Cells

Michael Shelton et al.

STEM CELL REPORTS (2014)

Article Cell Biology

Transplantation of Genetically Corrected Human iPSC-Derived Progenitors in Mice with Limb-Girdle Muscular Dystrophy

Francesco Saverio Tedesco et al.

SCIENCE TRANSLATIONAL MEDICINE (2012)

Article Developmental Biology

The epaxial-hypaxial subdivision of the avian somite

L Cheng et al.

DEVELOPMENTAL BIOLOGY (2004)

Article Biochemistry & Molecular Biology

Dystrophin and utrophin influence fiber type composition and post-synaptic membrane structure

JA Rafael et al.

HUMAN MOLECULAR GENETICS (2000)