4.3 Article

Hepatitis B virus promotes hepatocellular carcinoma development by activating GP73 to repress the innate immune response

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GP73 is a TBC-domain Rab GTPase-activating protein contributing to the pathogenesis of non-alcoholic fatty liver disease without obesity

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Summary: The study reveals that dysregulation of lipid metabolism and transport contribute to non-alcoholic fatty liver disease (NAFLD), with GP73 identified as a TBC-domain Rab GTPase-activating protein that regulates very low-density lipoprotein export and promotes NAFLD development in mice.

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