4.5 Article

Excessive IL-15 promotes cytotoxic CD4+CD28-T cell-mediated renal injury in lupus nephritis

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Cardiac & Cardiovascular Systems

Interleukin-7 and interleukin-15 drive CD4+CD28null T lymphocyte expansion and function in patients with acute coronary syndrome

Jessica Bullenkamp et al.

Summary: CD28(null) T cells expand preferentially in patients with acute coronary syndrome (ACS), and IL-7 and IL-15 drive this expansion while enhancing their cytotoxic function and interferon-gamma production. Blocking the IL-7/IL-15 signaling pathway may prevent the expansion of these cells and improve patient outcomes.

CARDIOVASCULAR RESEARCH (2021)

Review Rheumatology

Update on the diagnosis and management of systemic lupus erythematosus

Antonis Fanouriakis et al.

Summary: Systemic lupus erythematosus (SLE) is characterized by clinical heterogeneity, unpredictable course and flares. Diagnosis remains clinical with limited serologic test confirmation, and newer classification criteria offer more accurate classification. Treatment goals focus on patient survival, flare prevention, organ damage prevention, and quality of life optimization. High-intensity immunosuppressive therapy followed by less intensive therapy is typically used to control disease activity in severe cases of SLE.

ANNALS OF THE RHEUMATIC DISEASES (2021)

Article Medicine, Research & Experimental

Glomerular endothelial cell senescence drives age-related kidney disease through PAI-1

Camille Cohen et al.

Summary: The study uncovered a detrimental cross-talk between senescent glomerular endothelial cells and podocytes through PAI-1, affecting glomerular lesion development and podocyte loss in aged mice. Selective inactivation of PAI-1 or blocking its action prevented podocyte apoptosis, and depletion of senescent cells prevented podocyte loss in old transgenic mice. Furthermore, glomerular PAI-1 expression was predictive of poor outcomes in elderly donor kidney transplants and urinary PAI-1 levels were associated with age-related chronic kidney disease in elderly patients.

EMBO MOLECULAR MEDICINE (2021)

Article Immunology

Association between tubulointerstitial CD8+T cells and renal prognosis in lupus nephritis

Ti Zhang et al.

Summary: In patients with lupus nephritis, the number of tubulointerstitial CD8+T cells correlates with clinicohistologic impairment, and levels exceeding 130/mm(2) are independently associated with an unfavorable kidney outcome.

INTERNATIONAL IMMUNOPHARMACOLOGY (2021)

Review Immunology

T cell markers recount the course of immunosenescence in healthy individuals and chronic kidney disease

Georgios Lioulios et al.

Summary: Aging leads to significant changes in almost all cellular subpopulations within the immune system, with T lymphocytes undergoing functional and phenotypic alterations. These changes, known as immunosenescence, are also observed in chronic kidney disease, where T cells of young patients resemble those of healthy older individuals. Various surface markers can be used to identify immunosenescent T cells, which may have potential connections with impaired renal function.

CLINICAL IMMUNOLOGY (2021)

Review Immunology

Hallmarks of T cell aging

Maria Mittelbrunn et al.

Summary: In this Review, Mittelbrunn and Kroemer propose ten molecular hallmarks as common denominators of T cell aging, which include primary and secondary hallmarks explaining the manifestation of T cell aging and its impact on overall deterioration. The challenge now is to weigh the relative impact of these hallmarks on T cell aging and understand their interconnections, with the goal of defining molecular targets for interventions in the aging process.

NATURE IMMUNOLOGY (2021)

Article Immunology

CMV Status Drives Distinct Trajectories of CD4+T Cell Differentiation

Weiwen Zhang et al.

Summary: T cells induced by CMV infection can have long-term impact on immune responses, potentially detrimental to transplant patients.

FRONTIERS IN IMMUNOLOGY (2021)

Article Immunology

Maternal CMV seroprevalence rate in early gestation and congenital cytomegalovirus infection in a Chinese population

Yue Huang et al.

Summary: In China, the prevalence of CMV infection is high among pregnant women, while the prevalence of congenital CMV infection is relatively low. The majority of cCMV-positive newborns are born to mothers who are CMV seropositive.

EMERGING MICROBES & INFECTIONS (2021)

Review Immunology

Interleukin-15 (dys)regulation of lymphoid homeostasis: Implications for therapy of autoimmunity and cancer

Thomas A. Waldmann et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2020)

Article Medicine, General & Internal

Lupus nephritis

Hans-Joachim Anders et al.

NATURE REVIEWS DISEASE PRIMERS (2020)

Review Immunology

Autoimmunity and organ damage in systemic lupus erythematosus

George C. Tsokos

NATURE IMMUNOLOGY (2020)

Article Multidisciplinary Sciences

Macrophage metabolic reprogramming presents a therapeutic target in lupus nephritis

Chenzhi Jing et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Review Immunology

Mechanisms underlying T cell ageing

Jorg J. Goronzy et al.

NATURE REVIEWS IMMUNOLOGY (2019)

Review Urology & Nephrology

Cellular senescence in renal ageing and disease

Ines Sturmlechner et al.

NATURE REVIEWS NEPHROLOGY (2017)

Article Urology & Nephrology

Chronic kidney disease and premature ageing

Jeroen P. Kooman et al.

NATURE REVIEWS NEPHROLOGY (2014)

Article Rheumatology

Shortened Telomere Length in Patients With Systemic Lupus Erythematosus

Sahena Haque et al.

ARTHRITIS AND RHEUMATISM (2013)

Article Biochemistry & Molecular Biology

Molecular basis for the loss of CD28 expression in senescent T cells

AN Vallejo et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2002)