期刊
IMMUNITY & AGEING
卷 19, 期 1, 页码 -出版社
BMC
DOI: 10.1186/s12979-022-00294-9
关键词
SARS-CoV-2; COVID-19; Telomere length; Pulmonary fibrosis
资金
- FOREUM Foundation for Research in Rheumatology
- Fondo de Investigacion Sanitaria, Instituto de Salud Carlos III [PI19/01129, COV20/00181, RICOR RD21/0002]
- European Regional Development Fund (FEDER)
This study analyzed leukocyte telomere length in patients with severe COVID-19 and found that shorter telomere length is associated with COVID-19 hospitalization, but not with hospital clinical outcomes or persistent post-COVID-19 manifestations.
Background Age and comorbidity are the main determinants of COVID-19 outcome. Shorter leukocyte telomere length (TL), a hallmark of biological aging, has been associated with worse COVID-19 outcomes. We sought to determine TL in patients with severe COVID-19 requiring hospitalization to analyze whether clinical outcomes and post-COVID-19 manifestations are associated with shorter TL. Results We analyzed 251 patients with PCR-confirmed COVID-19, hospitalized in the first months of the pandemics. We determined TL in PBL at admission by quantitative-PCR (qPCR) analysis in patients. A healthy cohort from the same area with a similar age range (n = 169) was used to calculate TL Z-scores. After hospital discharge, 144 COVID-19 survivors were followed-up for persistent COVID-19 manifestations. A second TL determination was performed in a smaller group of 63 patients 1 year later and compared with baseline TL. Hospitalized COVID-19 patients had a decreased baseline age-adjusted TL Z-score compared to the reference group. No differences in Z-scores were observed in patients with different COVID-19 outcomes, classified as WHO ordinal scores. In 144 patients, followed for a median of 8 months, post-COVID manifestations were not associated to differences in TL. Persistence of lung radiographic abnormalities was associated with shorter baseline TL. In patients with a second TL determination, further telomere shortening (TS) was observed in 35% and telomere lengthening in 49%. Patients with further TS had suffered a more severe disease. Conclusion Shorter TL is associated with COVID-19 hospitalization but not with hospital clinical outcomes nor with persistent post-COVID-19 manifestations. Delayed resolution of radiographic lung abnormalities was also associated with shorter TL.
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