☆ 4.6 Review

Dissemination and prevalence of plasmid-mediated high-level tigecycline resistance gene tet (X4)

FRONTIERS IN MICROBIOLOGY (2022)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。
Article Infectious Diseases

Detection of the transferable tigecycline resistance gene tet(X4) in Escherichia coli from pigs in the United Kingdom

Francesca Martelli et al.

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2022)

添加到收藏夹
Review Engineering, Environmental

Monitoring antibiotic resistance genes in wastewater environments: The challenges of filling a gap in the One-Health cycle

Aleksandra Milobedzka et al.

Summary: Antibiotic resistance (AR) is a global issue that requires international cooperation and coordinated action. Global monitoring of AR occurrence and dissemination paths must rely on comparable methods, while taking into account distinct needs and available resources. Despite the challenges posed by the diverse methodological approaches and variable features of monitored sites, fostering dialogue between different methods and producing action-oriented data is crucial.

JOURNAL OF HAZARDOUS MATERIALS (2022)

添加到收藏夹
Article Environmental Sciences

Widespread prevalence and molecular epidemiology of tet(X4) and mcr-1 harboring Escherichia coli isolated from chickens in Pakistan

Ruichao Li et al.

Summary: This study described the molecular epidemiology of tet(X4) and mcr-1 harboring E. coli strains of chicken origin in Pakistan, with over 30 isolates showing high levels of tigecycline and colistin resistance. Various plasmid carriers and co-transfer frequencies were observed. The findings provide new insights for preventing and controlling the spread of antibiotic resistance genes.

SCIENCE OF THE TOTAL ENVIRONMENT (2022)

添加到收藏夹
Article Environmental Sciences

Structural diversity of the ISCR2-mediated rolling-cycle transferable unit carrying tet(X4)

Dejun Liu et al.

Summary: This study analyzed the diversity of ISCR2 and tet(X4) from different sources, and the results showed that ISCR2 plays a critical role in the dissemination of tet(X4) and other resistance genes.

SCIENCE OF THE TOTAL ENVIRONMENT (2022)

添加到收藏夹
Article Environmental Sciences

Comprehensive analysis of plasmid-mediated tet(X4)-positive Escherichia coli isolates from clinical settings revealed a high correlation with animals and environments-derived strains

Chao-Yue Cui et al.

Summary: The emergence of novel plasmid-mediated high-level tigecycline resistance genes tet(X) in Enterobacteriaceae poses a public health risk. A comprehensive analysis of tet(X4)-positive Escherichia coli isolates from a hospital in Guangdong province, China revealed genetic diversity among these isolates, with certain strains showing clonal transmission. Most tet(X4) genes were located on conjugative plasmids and coexisted with other antibiotic resistance genes in patient isolates. The IncX1 plasmid type was a common vector for tet(X4) and demonstrated strong transmission ability and wide host range. Phylogenetic analysis indicated potential cross-sectorial clonal transmission between human and animal-derived tet(X4)-positive E. coli isolates.

SCIENCE OF THE TOTAL ENVIRONMENT (2022)

添加到收藏夹
Article Environmental Sciences

Swine manure facilitates the spread of antibiotic resistome including tigecycline-resistant tet(X) variants to farm workers and receiving environment

Cuihong Tong et al.

Summary: The study revealed a high richness and diversity of ARGs in swine manure, with inactivating tetracycline resistance genes being prevalent. Workers and the environment were identified as primary recipients of ARGs, with shared ARGs accounting for at least 90% of their ARG abundances. Network analysis showed Escherichia, Acinetobacter, and Erysipelothrix as the most dominant genera co-occurring with specific shared ARGs.

SCIENCE OF THE TOTAL ENVIRONMENT (2022)

添加到收藏夹
Article Infectious Diseases

Detection of tet(X6) variant-producing Proteus terrae subsp. cibarius from animal cecum in Zhejiang, China

Xue Zheng et al.

Summary: This study analyzed the genetic contexts of the tet(X6) gene in Proteus spp. and highlighted the significance of monitoring tigecycline-resistant P. terrae subsp. cibarius.

JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE (2022)

添加到收藏夹
Article Microbiology

Bismuth Drugs Reverse Tet(X)-Conferred Tigecycline Resistance in Gram-Negative Bacteria

Tian Deng et al.

Summary: Antibiotic resistance poses a serious threat to public health and human safety. The emergence of the novel resistance gene tet(X4) and its variants has jeopardized the clinical utility of tigecycline, a last-line antibiotic for multidrug-resistant bacterial infections. However, the combination of bismuth drugs, particularly bismuth nitrate [Bi(NO3)(3)], with tigecycline has shown to effectively enhance its antibacterial activity against tet(X)-positive bacteria. This is achieved by inhibiting the enzymatic activity of the Tet(X) protein through competitive and noncompetitive binding mechanisms.

MICROBIOLOGY SPECTRUM (2022)

添加到收藏夹
Article Microbiology

Presence of Mobile Tigecycline Resistance Gene tet(X4) in Clinical Klebsiella pneumoniae

Weishuai Zhai et al.

Summary: This study identified a clinical Klebsiella pneumoniae isolate harboring the tet(X4) gene on a non-self-transferable plasmid. The plasmid could be cotransferred with another conjugative plasmid to Escherichia coli, suggesting an increasing risk of spreading tet(X4) among important pathogens.

MICROBIOLOGY SPECTRUM (2022)

添加到收藏夹
Article Environmental Sciences

Characteristics and removal of antibiotics and antibiotic resistance genes in a constructed wetland from a drinking water source in the Yangtze River Delta

Jinping Du et al.

Summary: Safe drinking water is crucial to public health, but approximately one-third of the world's population lacks access to clean drinking water. Antibiotics and ARGs in drinking water have become a severe problem, and a study in a constructed wetland in China found that 22 antibiotics and 9 ARGs were present, with some removal efficiency in the wetland system.

SCIENCE OF THE TOTAL ENVIRONMENT (2022)

添加到收藏夹
Article Microbiology

Extensive spread of tet(X4) in multidrug-resistant Escherichia coli of animal origin in western China

Jie Feng et al.

Summary: The study revealed a high prevalence of the tet(X4) tigecycline resistance gene in western China, particularly in Guangxi, Ningxia, and Shanxi. These isolates exhibited multidrug resistance and were capable of transferring tet(X4) via plasmids. The findings underscore the need for further evaluation of the impact of these tigecycline resistance genes and their spread in the region.

VETERINARY MICROBIOLOGY (2022)

添加到收藏夹
Article Engineering, Environmental

A mixed blessing of viruses in wastewater treatment plants

Ling-Dong Shi et al.

Summary: The diversity of both microorganisms and viruses in activated sludge of wastewater treatment plants plays a crucial role in controlling microbial dynamics and metabolisms. This study reveals the presence of unknown viral genera in activated sludge, indicating an unexplored reservoir for new viruses and viral diversity. The study also shows that viruses can enhance the performance of activated sludge by encoding auxiliary metabolic genes (AMGs) involved in biodegradation, but can also facilitate the spread of antibiotic resistance genes (ARGs) among microorganisms. Overall, this study highlights the mixed blessing of viruses in wastewater treatment plants and their impact on biochemical processes.

WATER RESEARCH (2022)

添加到收藏夹
Article Multidisciplinary Sciences

Antimicrobial resistance and population genomics of multidrug-resistant Escherichia coli in pig farms in mainland China

Zhong Peng et al.

Summary: The expanding use of antimicrobials in livestock has led to a rapid increase in antimicrobial resistance (AMR). A large-scale study on AMR in pig farms in China found that E. coli isolates from pigs and their breeding environments in all provinces showed AMR, with 91% of isolates demonstrating multidrug resistance. These isolates showed resistance to last-resort drugs and carried multiple resistance genes, virulence factor-encoding genes, and putative plasmids.

NATURE COMMUNICATIONS (2022)

添加到收藏夹
Article Infectious Diseases

Broad-host-range IncW plasmid harbouring tet(X) in Escherichia coli isolated from pigs in Japan

Masaru Usuia et al.

Summary: This study retrospectively analyzed the prevalence of the tet(X) resistance gene among pigs in Japan and reported the emergence of an IncW plasmid harboring tet(X) for the first time. The selective pressure exerted by the use of tetracyclines in livestock contributes to the spread of tet(X) plasmids, highlighting the need for prudent use of tetracyclines.

JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE (2022)

添加到收藏夹
Letter Infectious Diseases

Detection of Tet ( X4 )-producing Klebsiella pneumoniae from the environment and wide spread of IncFIA-IncHI1A-IncHI1B plasmid carrying tet(X4) in China

Xun Gao et al.

JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE (2022)

添加到收藏夹
Article Pharmacology & Pharmacy

Emergence of mobile tigecycline resistance gene tet(X4)-harbouring Shewanella xiamenensis in a water environment

Trung Duc Dao et al.

Journal of Global Antimicrobial Resistance (2022)

添加到收藏夹
Article Medicine, General & Internal

A novel inhibitor of monooxygenase reversed the activity of tetracyclines against tet(X3)/tet(X4)-positive bacteria

Lei Xu et al.

Summary: This study identified plumbagin as an effective broad-spectrum inhibitor of Tet(X3)/Tet(X4), which can synergistically kill bacteria producing these resistant genes when used in combination with tetracyclines.

EBIOMEDICINE (2022)

添加到收藏夹
Article Microbiology

Identification of Plasmid-Mediated Tigecycline-Resistant Gene tet(X4) in Enterobacter cloacae from Pigs in China

Yiping Wu et al.

Summary: We identified two tet(X4)-positive E. cloacae isolates and found that the pTECL_2-190k-tetX4-like plasmid has been widely disseminated across various species of Enterobacteriaceae. By analyzing 85 tet(X4)-carrying plasmids, we determined that these plasmids have multiple replicon types, including IncFIA, IncHI1A, and IncHI1B.

MICROBIOLOGY SPECTRUM (2022)

添加到收藏夹
Article Environmental Sciences

Mobile tigecycline resistance gene tet(X4) persists with different animal manure composting treatments and fertilizer receiving soils

Shiting Dai et al.

Summary: This study investigated the environmental behavior of mobile tet(X)-variant genes in manure composting treatments and amended soils. The results showed that tet(X4) was the most prevalent mobile tet(X)-variant gene, and it exhibited the lowest reduction after thermophilic composting, possibly due to its correlation with ISCR2.

CHEMOSPHERE (2022)

添加到收藏夹
Article Engineering, Environmental

Characteristics of Wild Bird Resistomes and Dissemination of Antibiotic Resistance Genes in Interconnected Bird-Habitat Systems Revealed by Similarity of blaTEM Polymorphic Sequences

Yi Luo et al.

Summary: This study reveals the presence of extensive antibiotic resistance genes (ARGs) in wild bird feces and their exchange with their habitats. It highlights the potential of high-mobility birds as vectors for global propagation of ARGs.

ENVIRONMENTAL SCIENCE & TECHNOLOGY (2022)

添加到收藏夹
Article Microbiology

Emergence and Characterization of Tigecycline Resistance Gene tet(X4) in ST609 Escherichia coli Isolates from Wastewater in Turkey

Cemil Kurekci et al.

Summary: This study firstly described the presence and molecular characteristics of tet(X4)-positive E. coli isolates from wastewater in Turkey. These isolates belonged to the ST609 clone, which is commonly found in humans, animals and the environment. These findings highlight the importance of monitoring the tet(X4) gene in different settings globally.

MICROBIOLOGY SPECTRUM (2022)

添加到收藏夹
Article Food Science & Technology

International Spread of Tet(X4)-Producing Escherichia coli Isolates

Zengfeng Zhang et al.

Summary: Tigecycline resistance in bacteria poses a significant threat to food safety and public health, with international spread mainly occurring in Asian countries. Pigs and their products are the most common vehicle for transmission.

FOODS (2022)

添加到收藏夹
Article Food Science & Technology

Distinct increase in antimicrobial resistance genes among Escherichia coli during 50 years of antimicrobial use in livestock production in China

Lu Yang et al.

Summary: Genomic analyses of Escherichia coli samples from livestock in China reveal a significant increase in the number of plasmids over the past 50 years, contributing to the spread of antimicrobial resistance. The study also found a doubling of antimicrobial resistance genes per isolate, including resistance to important drugs for both veterinary and human medicine. The increase in plasmids of various incompatibility groups acts as an effective means of spreading antimicrobial resistance genes.

NATURE FOOD (2022)

添加到收藏夹
Letter Infectious Diseases

Characterization of three porcine Escherichia coli isolates co-harbouring tet(X4) and cfr

Yizhi Tang et al.

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2021)

添加到收藏夹
Article Engineering, Environmental

Dissemination of the tet(X)-Variant Genes from Layer Farms to Manure-Receiving Soil and Corresponding Lettuce

Tao He et al.

Summary: The emergence of high-level tigecycline resistance tet(X) variant genes poses a new transferable resistance crisis to food safety and human health, with these genes being widely present in samples from layer manures, soils, and lettuce. The detection rate of tet(X)/(X2) was the highest, and tet(X)/tet(X2) and tet(X3) were more abundant in manured soils and lettuce samples.

ENVIRONMENTAL SCIENCE & TECHNOLOGY (2021)

添加到收藏夹
Review Biotechnology & Applied Microbiology

Prevalence and Traits of Mobile Colistin Resistance Gene Harbouring Isolates from Different Ecosystems in Africa

Madubuike Umunna Anyanwu et al.

Summary: The mobile colistin resistance (mcr) gene poses a threat to the effectiveness of colistin, a last-resort antibiotic, in Africa where the regulation of critically important antimicrobial agents like colistin is lacking. Various mcr genes have been detected in isolates from humans, animals, foods, and the environment on the continent, leading to increased antimicrobial resistance and virulence in African strains. Transmission routes of mcr-containing bacteria in Africa include contact with reservoirs, consumption of contaminated foods, and trade and travel.

BIOMED RESEARCH INTERNATIONAL (2021)

添加到收藏夹
Article Microbiology

Co-production of Tet(X) and MCR-1, two resistance enzymes by a single plasmid

Yongchang Xu et al.

Summary: The co-carriage of tet(X6) and mcr-1 in Escherichia coli leads to resistance to both tigecycline and colistin antibiotics. The presence of Tet(X6) and MCR-1 appears to be a major concern in infection treatment.

ENVIRONMENTAL MICROBIOLOGY (2021)

添加到收藏夹
Article Food Science & Technology

Investigation of tigecycline resistant Escherichia coli from raw meat reveals potential transmission among food-producing animals

Honghu Sun et al.

Summary: The study identified tet(X4)-carrying E. coli in retail raw meat from Sichuan Province, with the highest prevalence in pork. Analysis revealed two dominant sequence types and potential clone-like transmission clusters, indicating the extensive and successful spread of tet(X4) among different food-producing animals.

FOOD CONTROL (2021)

添加到收藏夹
Review Environmental Sciences

Updates on the global dissemination of colistin-resistant Escherichia coli: An emerging threat to public health

Shaqiu Zhang et al.

Summary: Colistin drug resistance is an emerging public health threat worldwide, with prevalence in multiple reservoirs and ecological environmental settings. Escherichia coli carrying mobile colistin resistance genes exhibit abundant clinically important resistance genes and are spread through various plasmid replicon types.

SCIENCE OF THE TOTAL ENVIRONMENT (2021)

添加到收藏夹
Review Environmental Sciences

Interaction between tetracycline and microorganisms during wastewater treatment: A review

Quan Liao et al.

Summary: Tetracycline (TC) is a commonly used antibiotic in human and veterinary medicine, which is discharged into wastewater as parent compounds. The activated sludge processes in wastewater treatment plants are not effective in removing TC, and the impact of TC in wastewater treatment processes and removal methods should be emphasized.

SCIENCE OF THE TOTAL ENVIRONMENT (2021)

添加到收藏夹
Article Microbiology

Spread of tet(X5) and tet(X6) genes in multidrug-resistant Acinetobacter baumannii strains of animal origin

Chong Chen et al.

Summary: The recent discovery of plasmid-mediated tigecycline-resistant gene tet(X) in sick ducks and chickens in Guangdong, China, challenges the clinical effectiveness of tigecycline. The isolates exhibited high degradation activities on tetracyclines by hydroxylation and showed multidrug resistance to several antibiotics. Additional efforts are needed to evaluate the clinical impact of these tigecycline resistance genes.

VETERINARY MICROBIOLOGY (2021)

添加到收藏夹
Letter Infectious Diseases

Co-occurrence of plasmid-mediated resistance genes tet(X4) and blaNDM-5 in a multidrug-resistant Escherichia coli isolate recovered from chicken in China

Honghu Sun et al.

JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE (2021)

添加到收藏夹
Review Immunology

Antibiotic Resistance: One Health One World Outlook

Bilal Aslam et al.

Summary: Antibiotic resistance is a global public health concern that requires an integrated One Health approach for effective mitigation. Global interdisciplinary and unified approaches are essential to limit the dissemination cycle of antibiotic resistance, raise awareness and education about antibiotic use, and promote policy, advocacy, and antimicrobial stewardship.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2021)

添加到收藏夹
Article Microbiology

Occurrence and Molecular Characterization of Abundant tet(X) Variants Among Diverse Bacterial Species of Chicken Origin in Jiangsu, China

Yingshan Li et al.

Summary: The study identified widespread dissemination of different tet(X) variants in the chicken farming environment, with tet(X4) being the dominant variant. It is recommended to limit antibiotic usage to control the emergence and transmission of novel tet(X) variants in the poultry industry.

FRONTIERS IN MICROBIOLOGY (2021)

添加到收藏夹
Article Microbiology

Histone-Like Nucleoid Structuring Protein Modulates the Fitness of tet(X4)-Bearing IncX1 Plasmids in Gram-Negative Bacteria

Wenhui Cai et al.

Summary: The IncX1-type plasmid is a common vector for spreading the tet(X4) gene, with H-NS protein encoded by the tet(X4)-bearing plasmids facilitating virulence and biofilm formation in host bacteria. The expression of the hns gene positively impacts the fitness of host bacteria, while negatively correlating with the expression of the tet(X4) gene, indicating a regulatory role in adaptability.

FRONTIERS IN MICROBIOLOGY (2021)

添加到收藏夹
Article Infectious Diseases

First report of mobile tigecycline resistance gene tet(X4)-harbouring multidrug-resistant Escherichia coli from wastewater in Norway

Nachiket P. Marathe et al.

Summary: The study revealed a tigecycline-resistant Escherichia coli strain isolated from sewage in Norway carrying the mobile tet(X4) gene, conferring resistance to multiple antibiotics, including tetracyclines. Through conjugation assays, the strain showed the ability to transfer tigecycline resistance to other strains.

JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE (2021)

添加到收藏夹
Review Environmental Sciences

Distribution of genetic elements associated with antibiotic resistance in treated and untreated animal husbandry waste and wastewater

Andressa Rezende Pereira et al.

Summary: Animal breeding for meat production, especially based on swine, cattle, poultry, and aquaculture, has raised concerns related to the spread of antibiotic resistance. Studies show that biological treatments like waste composting and anaerobic digestion are effective in removing antibiotic resistance genes, but some genes remain persistent and may require advanced oxidative processes for further reduction. It is crucial to optimize operational parameters such as temperature, hydraulic retention time, and sunlight penetration to effectively reduce antibiotic resistance genes in animal waste treatments.

ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH (2021)

添加到收藏夹
Review Biochemistry & Molecular Biology

Acquisition and Spread of Antimicrobial Resistance: A tet(X) Case Study

Rustam Aminov

Summary: Understanding the mechanisms behind the development of antimicrobial resistance is crucial, but monitoring and detection measures have been significantly delayed and focused mainly on bacterial pathogens, missing key events before resistance emerges. Recent developments in antimicrobial resistance may provide valuable insights into the driving mechanisms of resistance evolution.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

添加到收藏夹
Article Engineering, Environmental

Abundance of tigecycline resistance genes and association with antibiotic residues in Chinese livestock farms

Yulin Fu et al.

Summary: The study found that tet(X4), tmexCD1-toprJ1, and other tigecycline resistance genes were more abundant in chicken feces, indicating a higher risk of TRG propagation in chicken feces. Positive correlations between ISCR2/IS26 and TRGs further demonstrated the potential transfer and mobilization of these resistance genes.

JOURNAL OF HAZARDOUS MATERIALS (2021)

添加到收藏夹
Article Genetics & Heredity

Distribution and genomic characterization of tigecycline-resistant tet(X4)-positive Escherichia coli of swine farm origin

Yan Li et al.

Summary: The study identified tigecycline-resistant Escherichia coli strains carrying the tet(X4) gene in swine farms, which showed resistance to tigecycline. Through various experiments and analyses, different sequence types and prophages carrying different resistance genes were found, as well as possible correlations between CRISPR spacer sequences and serotypes or sequence types. The co-existence of tet(A) variants and tet(X4) complicates the evolution of resistance genes in farming environments.

MICROBIAL GENOMICS (2021)

添加到收藏夹
Article Microbiology

Comprehensive Genomic Investigation of Tigecycline Resistance Gene tet(X4)-Bearing Strains Expanding among Different Settings

Ruichao Li et al.

Summary: This study identified 58 strains of bacteria carrying the tet(X4) gene in fresh pork samples from multiple regions in China, with Escherichia coli being the predominant species. Four novel tet(X4)-positive bacterial species were also characterized. Genetic analysis revealed various types of core tet(X4)-bearing genetic environments and tandem duplications. The study highlights the potential transmission risk of animal-borne tet(X4)-bearing pathogens in consumed food, emphasizing the urgent need for large-scale monitoring and effective control measures.

MICROBIOLOGY SPECTRUM (2021)

添加到收藏夹
Article Microbiology

Source Tracking and Global Distribution of the Tigecycline Non-Susceptible tet(X)

Rong-Min Zhang et al.

Summary: The emergence of tet(X) genes has compromised the clinical use of the last-line antibiotic tigecycline, with new tet(X) genes identified in human microbiome samples and their distribution patterns in Bacteroidaceae highlighted. The study emphasizes the potential threat of tet(X) genes to public health and the importance of monitoring their spread in various bacterial populations.

MICROBIOLOGY SPECTRUM (2021)

添加到收藏夹
Article Microbiology

Sporadic Dissemination of tet(X3) and tet(X6) Mediated by Highly Diverse Plasmidomes among Livestock-Associated Acinetobacter

Ying-Ying Cheng et al.

Summary: The study identified clonal and sporadic dissemination patterns of plasmid-borne tet(X) genes in Acinetobacter isolates from livestock farms. Plasmid pAT181 was found to be self-transmissible and increased tigecycline resistance and growth rate. The structure of tet(X3) and tet(X6) plasmidomes exhibited high diversity in dissemination.

MICROBIOLOGY SPECTRUM (2021)

添加到收藏夹
Article Infectious Diseases

An Outbreak of tet(X6)-Carrying Tigecycline-Resistant Acinetobacter baumannii Isolates with a New Capsular Type at a Hospital in Taiwan

Yu-Chia Hsieh et al.

Summary: The study found that seven strains of tigecycline-non-susceptible Acinetobacter baumannii isolates in Taiwan carried tet(X)-like genes, which were considered outbreak strains. The co-harboring of tet(X6) and bla(OXA-72) genes in these strains highlights the potential risk of spreading tigecycline- and carbapenem-resistant A. baumannii in healthcare settings.

ANTIBIOTICS-BASEL (2021)

添加到收藏夹
Article Infectious Diseases

A method for screening tigecycline-resistant gene tet(X) from human gut

Yu Zeng et al.

Summary: The study developed an effective enrichment method for tet(X) detection using PCR and Sanger sequencing. Results showed a 2.26% prevalence of tet(X4)-positive Escherichia coli, with 96.6% exhibiting resistance to tigecycline. This specific screening strategy will aid in advancing knowledge of tet(X) and tigecycline resistance mechanisms.

JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE (2021)

添加到收藏夹
Article Microbiology

Evolutionary Trajectory of the Tet(X) Family: Critical Residue Changes towards High-Level Tigecycline Resistance

Chao-Yue Cui et al.

Summary: This study identified key residue changes that enhance Tet(X) activity and highlighted their crucial role in the molecular evolution of Tet(X) orthologs. These mutations indirectly affect enzyme activity by altering the conformational dynamics and provide insights into the evolutionary relationship between Tet(X) orthologs.

MSYSTEMS (2021)

添加到收藏夹
Article Infectious Diseases

Antibiotic-Resistant Enterobacteriaceae in Wastewater of Abattoirs

Timo Homeier-Bachmann et al.

Summary: Antibiotic-resistant Enterobacteriaceae are commonly found in wastewaters from pig and poultry slaughterhouses, with high rates of multidrug resistance. Colistin-resistant Enterobacteriaceae were detected in both poultry and pig water samples, while no carbapenem resistance was found. These resistant bacteria were directly observed in discharge from abattoirs, indicating the potential contamination of environmental surfaces.

ANTIBIOTICS-BASEL (2021)

添加到收藏夹
Article Environmental Sciences

Distribution and association of antimicrobial resistance and virulence traits in Escherichia coli isolates from healthy waterfowls in Hainan, China

Shaqiu Zhang et al.

Summary: The study revealed that healthy waterfowls harbor E. coli with multiple ARGs and various ExPEC-associated VAGs. The findings suggest the need for regulated antibiotic use to prevent the direct or indirect spread of these resistant and potentially pathogenic microbes to the natural environment.

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2021)

添加到收藏夹
Article Environmental Sciences

More diversified antibiotic resistance genes in chickens and workers of the live poultry markets

Yanan Wang et al.

Summary: The study reveals the significant impact of the live poultry trade on the diversity of antimicrobial resistance genes in LPM workers, chickens, and environments in China. The LPMs possess a greater diversity of antimicrobial resistance genes, some of which are also carried by human clinical pathogens.

ENVIRONMENT INTERNATIONAL (2021)

添加到收藏夹
Article Microbiology

The poultry pathogen Riemerella anatipestifer appears as a reservoir for Tet(X) tigecycline resistance

Zeeshan Umar et al.

Summary: The study identified 26 new variants of the tigecycline resistance gene tet(X) from the poultry pathogen Riemerella anatipestifer, expanding the current family extensively. R. anatipestifer is shown to be a natural reservoir for tet(X), with varied copies of tet(X) progenitors on its chromosome. A potential progenitor of tet(X), Tet(X2/4)-P, was characterized to show intermediate tigecycline resistance.

ENVIRONMENTAL MICROBIOLOGY (2021)

添加到收藏夹
Article Environmental Sciences

Emergence of plasmid-mediated tigecycline resistance tet(X4) gene in Escherichia coli isolated from poultry, food and the environment in South Asia

Mashkoor Mohsin et al.

Summary: The study identified plasmid-mediated tigecycline and colistin resistance genes in E. coli isolates from different sources in Pakistan, with tet(X4) being transferable by conjugation. This poses a serious threat to human health as the convergence of tigecycline and colistin resistance is detected in South Asia.

SCIENCE OF THE TOTAL ENVIRONMENT (2021)

添加到收藏夹
Review Microbiology

The Role of Gulls as Reservoirs of Antibiotic Resistance in Aquatic Environments: A Scoping Review

Danae Zeballos-Gross et al.

Summary: The role of wildlife with long-range dispersal, such as gulls, in the global spread of antimicrobial resistance is still poorly understood. Future research, including standardization of sampling protocols, longitudinal sampling using advanced satellite tracking, and whole-genome sequencing typing, is needed to confirm the role of gulls in the spread of AMR.

FRONTIERS IN MICROBIOLOGY (2021)

添加到收藏夹
Article Microbiology

Prevalence of tet(X4) in Escherichia coli From Duck Farms in Southeast China

Yang Yu et al.

Summary: This study identified and characterized the prevalence of tet(X4) resistance gene in E. coli isolates from duck and goose farms in Southeast China. The presence of tet(X4) raises concerns about the widespread tigecycline resistance in animal farming and highlights the need for surveillance of this primary resistance gene.

FRONTIERS IN MICROBIOLOGY (2021)

添加到收藏夹
Article Infectious Diseases

Detection of a new tet(X6)-encoding plasmid in Acinetobacter towneri

Yingying Cheng et al.

Summary: This study characterized a novel plasmid carrying tet(X6) gene in a livestock-associated Acinetobacter towneri isolate, highlighting the potential dissemination of tigecycline resistance. Functional analysis showed that Tet(X6) activity was weaker than other variants. Continuous monitoring of plasmid-borne tet(X) genes is essential to control its spread.

JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE (2021)

添加到收藏夹
Article Microbiology

A Transferable IncC-IncX3 Hybrid Plasmid Cocarrying blaNDM-4, tet(X), and tmexCD3-toprJ3 Confers Resistance to Carbapenem and Tigecycline

Aki Hirabayashi et al.

Summary: This study identified a CPE isolate harboring both emerging tigecycline resistance factors for the first time, which simultaneously confer high-level resistance to multiple antimicrobials. The plasmid carrying these resistance genes poses a public health crisis due to the lack of effective antibiotics to combat the spread of multidrug-resistant bacteria.

MSPHERE (2021)

添加到收藏夹
Article Microbiology

Multiple Mechanisms of Tigecycline Resistance in Enterobacteriaceae from a Pig Farm, China

Jing Wang et al.

Summary: Tigecycline-resistant Enterobacteriaceae strains isolated from a pig farm in Shanghai, China carried tet(X) and tet(A) resistance genes, which were transmitted via plasmids or chromosomal integrative and conjugative elements (ICEs). The rational use of antibiotics and surveillance of antibiotic resistance in livestock are crucial to combat the emergence and spread of tigecycline resistance.

MICROBIOLOGY SPECTRUM (2021)

添加到收藏夹
Article Infectious Diseases

Genetic Characterization of the Tetracycline-Resistance Gene tet(X) Carried by Two Epilithonimonas Strains Isolated from Farmed Diseased Rainbow Trout, Oncorhynchus mykiss in Chile

Christopher Concha et al.

Summary: This study characterized the tet(X) genes carried by the resistant strains FP105 and FP233-J200, isolated from rainbow trout in Chile, which encode a monooxygenase that catalyzes the degradation of tetracycline antibiotics. The Tet(X) genes showed high amino acid similarity with those found in strains isolated from fish, indicating the potential reservoir of tet(X) genes in pathogenic strains occurring in Chilean salmonid farms. This study highlights the importance of understanding tet(X) carriage in Epilithonimonas strains and its impact on limiting antimicrobial therapies in freshwater salmonid farming.

ANTIBIOTICS-BASEL (2021)

添加到收藏夹
Article Infectious Diseases

Overexpression of the adeB Efflux Pump Gene in Tigecycline-Resistant Acinetobacter baumannii Clinical Isolates and Its Inhibition by (+)Usnic Acid as an Adjuvant

Nagaraju Bankan et al.

Summary: Acinetobacter species, especially Acinetobacter baumannii, exhibit multidrug resistance through efflux pump mechanisms. The natural compound (+)Usnic acid shows better efficacy as an efflux pump inhibitor compared to conventional inhibitors in lowering the minimum inhibitory concentration of tigecycline-resistant Acinetobacter baumannii isolates.

ANTIBIOTICS-BASEL (2021)

添加到收藏夹
Article Infectious Diseases

Detection of Plasmid-Mediated Tigecycline Resistance Gene tet(X4) in a Salmonella enterica Serovar Llandoff Isolate

Yanan Wang et al.

Summary: The study identified the plasmid-mediated tigecycline resistance gene tet(X4) in a Salmonella Llandoff strain isolated from a human in China for the first time and revealed that a total of 171 isolates carrying tet(X)-like genes are distributed across 21 countries or areas on 6 continents, posing a serious threat to humans and public health. Further surveillance is needed to prevent the spread of the tet(X)-like genes.

INFECTIOUS MICROBES & DISEASES (2021)

添加到收藏夹
Article Immunology

Novel tigecycline resistance mechanisms in Acinetobacter baumannii mediated by mutations in adeS, rpoB and rrf

Xiaoting Hua et al.

Summary: Acinetobacter baumannii is an important pathogen in hospital acquired infections. Although tigecycline remains effective for treating infections caused by multidrug resistant A. baumannii strains, reports of tigecycline resistant isolates have increased. This study identified mutations in adeS, rrf, and rpoB genes that are associated with tigecycline resistance in A. baumannii.

EMERGING MICROBES & INFECTIONS (2021)

添加到收藏夹
Review Engineering, Environmental

Impact factors of the accumulation, migration and spread of antibiotic resistance in the environment

Zibo Lin et al.

Summary: Antibiotic resistance poses significant risks to global public health and ecological environment. Horizontal gene transfer plays a crucial role in the spread of antibiotic resistance genes, and the presence of antibiotic-resistant genes and bacteria in the environment exacerbates the risk of antibiotic resistance transmission.

ENVIRONMENTAL GEOCHEMISTRY AND HEALTH (2021)

添加到收藏夹
Article Microbiology

Novel Plasmid-Mediated tet(X5) Gene Conferring Resistance to Tigecycline, Eravacycline, and Omadacycline in a Clinical Acinetobacter baumannii Isolate

Liyuan Wang et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2020)

添加到收藏夹
Review Medicine, Research & Experimental

Effectiveness and Safety of High Dose Tigecycline for the Treatment of Severe Infections: A Systematic Review and Meta-Analysis

Lei Zha et al.

ADVANCES IN THERAPY (2020)

添加到收藏夹
Article Microbiology

Co-occurrence of Plasmid-Mediated Tigecycline and Carbapenem Resistance in Acinetobacter spp. from Waterfowls and Their Neighboring Environment

Chao-Yue Cui et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2020)

添加到收藏夹
Article Infectious Diseases

A novel tigecycline resistance gene, tet(X6), on an SXT/R391 integrative and conjugative element in a Proteus genomospecies 6 isolate of retail meat origin

Dandan He et al.

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2020)

添加到收藏夹
Article Infectious Diseases

Identification of the novel tigecycline resistance gene tet(X6) and its variants in Myroides, Acinetobacter and Proteus of food animal origin

Dejun Liu et al.

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2020)

添加到收藏夹
Letter Infectious Diseases

Characterization of a porcine Proteus cibarius strain co-harbouring tet(X6) and cfr

Kai Peng et al.

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2020)

添加到收藏夹
Article Infectious Diseases

A Nosocomial Cluster of Tigecycline- and Vancomycin-Resistant Enterococcus faecium Isolates and the Impact of rpsJ and tet(M) Mutations on Tigecycline Resistance

Jennifer K. Bender et al.

MICROBIAL DRUG RESISTANCE (2020)

添加到收藏夹
Article Microbiology

Emergence of a Plasmid-Encoded Resistance-Nodulation-Division Efflux Pump Conferring Resistance to Multiple Drugs, Including Tigecycline, in Klebsiella pneumoniae

Luchao Lv et al.

MBIO (2020)

添加到收藏夹
Article Microbiology

Colistin Combined With Tigecycline: A Promising Alternative Strategy to Combat Escherichia coli Harboring blaNDM-5 and mcr-1

Yu-Feng Zhou et al.

FRONTIERS IN MICROBIOLOGY (2020)

添加到收藏夹
Letter Infectious Diseases

Characterization of Acinetobacter indicus co-harbouring tet(X3) and blaNDM-1 of dairy cow origin

Tao He et al.

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2020)

添加到收藏夹
Editorial Material Multidisciplinary Sciences

Discovery of tigecycline resistance genes tet(X3) and tet(X4) in live poultry market worker gut microbiomes and the surrounded environment

Yanan Wang et al.

SCIENCE BULLETIN (2020)

添加到收藏夹
Article Microbiology

Deciphering the Structural Diversity and Classification of the Mobile Tigecycline Resistance Gene tet(X)-Bearing Plasmidome among Bacteria

Ruichao Li et al.

MSYSTEMS (2020)

添加到收藏夹
Article Parasitology

Emergence of Escherichia coli isolates producing NDM-1 carbapenemase from waterfowls in Hainan island, China

Mujeeb Ur Rehman et al.

ACTA TROPICA (2020)

添加到收藏夹
Review Biochemistry & Molecular Biology

Emerging High-Level Tigecycline Resistance: Novel Tetracycline Destructases Spread via the Mobile Tet(X)

Liang-Xing Fang et al.

BIOESSAYS (2020)

添加到收藏夹
Article Microbiology

Emergence of Carbapenem- and Tigecycline-ResistantProteus cibariusof Animal Origin

Yan Li et al.

FRONTIERS IN MICROBIOLOGY (2020)

添加到收藏夹
Article Immunology

Identification of novel tetracycline resistance genetet(X14) and its co-occurrence withtet(X2) in a tigecycline-resistant and colistin-resistantEmpedobacter stercoris

Yingying Cheng et al.

EMERGING MICROBES & INFECTIONS (2020)

添加到收藏夹
Article Infectious Diseases

Novel IS26-mediated hybrid plasmid harbouring tet(X4) in Escherichia coli

Pengcheng Du et al.

JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE (2020)

添加到收藏夹
Letter Infectious Diseases

Co-existence of plasmid-mediated tigecycline and colistin resistance genes tet(X4) and mcr-1 in a community-acquired Escherichia coli isolate in China

Zhi Ruan et al.

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2020)

添加到收藏夹
Article Infectious Diseases

Preliminary view of the global distribution and spread of the tet(X) family of tigecycline resistance genes

Yu Pan et al.

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2020)

添加到收藏夹
Letter Infectious Diseases

A novel plasmid-borne tet(X6) variant co-existing with blaNDM-1 and blaOXA-58 in a chicken Acinetobacter baumannii isolate

Xing-Run Zheng et al.

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2020)

添加到收藏夹
Article Biology

Genomic epidemiology of animal-derived tigecycline-resistant Escherichia coli across China reveals recent endemic plasmid-encoded tet(X4) gene

Chengtao Sun et al.

COMMUNICATIONS BIOLOGY (2020)

添加到收藏夹
Article Microbiology

Chromosomal and Plasmid-Borne Tigecycline Resistance Genes tet(X3) and tet(X4) in Dairy Cows on a Chinese Farm

Rong Zhang et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2020)

添加到收藏夹
Article Food Science & Technology

Identification of Novel Plasmids Containing the Tigecycline Resistance Genetet(X4) inEscherichia coliIsolated from Retail Chicken Meat

Hong Lv et al.

FOODBORNE PATHOGENS AND DISEASE (2020)

添加到收藏夹
Article Infectious Diseases

Emergence of tigecycline- and eravacycline-resistant Tet(X4)-producing Enterobacteriaceae in the gut microbiota of healthy Singaporeans

Yichen Ding et al.

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2020)

添加到收藏夹
Article Environmental Sciences

Exploring tet (X)-bearing tigecycline-resistant bacteria of swine farming environments

Ruichao Li et al.

SCIENCE OF THE TOTAL ENVIRONMENT (2020)

添加到收藏夹
Article Multidisciplinary Sciences

Epidemiological and phylogenetic analysis reveals Flavobacteriaceae as potential ancestral source of tigecycline resistance gene tet(X)

Rong Zhang et al.

NATURE COMMUNICATIONS (2020)

添加到收藏夹
Article Microbiology

Coexistence ofblaOXA-58andtet(X) on a Novel Plasmid inAcinetobactersp. From Pig in Shanghai, China

Jing Wang et al.

FRONTIERS IN MICROBIOLOGY (2020)

添加到收藏夹
Article Genetics & Heredity

Genetic diversity and characteristics of high-level tigecycline resistance Tet(X) in Acinetobacter species

Chong Chen et al.

GENOME MEDICINE (2020)

添加到收藏夹
Article Infectious Diseases

Global Trends in Antimicrobial Use in Food Animals from 2017 to 2030

Katie Tiseo et al.

ANTIBIOTICS-BASEL (2020)

添加到收藏夹
Article Multidisciplinary Sciences

The role of spillover in antibiotic resistance

Scott W. Olesen et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

添加到收藏夹
Review Veterinary Sciences

Manure as a Potential Hotspot for Antibiotic Resistance Dissemination by Horizontal Gene Transfer Events

Tiago Lima et al.

VETERINARY SCIENCES (2020)

添加到收藏夹
Article Environmental Sciences

Dissemination of antibiotic resistance genes (ARGs) via integrons in Escherichia coli: A risk to human health

Shaqiu Zhang et al.

ENVIRONMENTAL POLLUTION (2020)

添加到收藏夹
Review Biochemistry & Molecular Biology

Horizontal transfer of antibiotic resistance genes in clinical environments

Nicole A. Lerminiaux et al.

CANADIAN JOURNAL OF MICROBIOLOGY (2019)

添加到收藏夹
Review Biochemistry & Molecular Biology

Antibiotic resistance in grass and soil

Ciara Tyrrell et al.

BIOCHEMICAL SOCIETY TRANSACTIONS (2019)

添加到收藏夹
Review Biochemistry & Molecular Biology

Bacteriophages as Environmental Reservoirs of Antibiotic Resistance

William Calero-Caceres et al.

TRENDS IN MICROBIOLOGY (2019)

添加到收藏夹
Review Chemistry, Medicinal

Efflux pump inhibitors of clinically relevant multidrug resistant bacteria

Andraz Lamut et al.

MEDICINAL RESEARCH REVIEWS (2019)

添加到收藏夹
Article Microbiology

Emergence of plasmid-mediated high-level tigecycline resistance genes in animals and humans

Tao He et al.

NATURE MICROBIOLOGY (2019)

添加到收藏夹
Article Infectious Diseases

Detection of plasmid-mediated tigecycline-resistant gene tet(X4) in Escherichia coli from pork, Sichuan and Shandong Provinces, China, February 2019

Li Bai et al.

EUROSURVEILLANCE (2019)

添加到收藏夹
Article Ecology

Viruses as key reservoirs of antibiotic resistance genes in the environment

Didier Debroas et al.

ISME JOURNAL (2019)

添加到收藏夹
Article Infectious Diseases

Antibiotic resistance gene reservoir in live poultry markets

Yanan Wang et al.

JOURNAL OF INFECTION (2019)

添加到收藏夹
Review Infectious Diseases

Global economic impact of antibiotic resistance: A review

Mohammad Ahmad et al.

JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE (2019)

添加到收藏夹
Article Microbiology

Plasmid-encoded tet(X) genes that confer high-level tigecycline resistance in Escherichia coli

Jian Sun et al.

NATURE MICROBIOLOGY (2019)

添加到收藏夹
Letter Microbiology

Cooccurrence of Two tet(X) Variants in an Empedobacter brevis Strain of Shrimp Origin

Ruichao Li et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2019)

添加到收藏夹
Letter Infectious Diseases

Detection of chromosome-mediated tet(X4)-carrying Aeromonas caviae in a sewage sample from a chicken farm

Chong Chen et al.

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2019)

添加到收藏夹
Review Biochemistry & Molecular Biology

ECF-Type ATP-Binding Cassette Transporters

S. Rempel et al.

ANNUAL REVIEW OF BIOCHEMISTRY, VOL 88 (2019)

添加到收藏夹
Editorial Material Multidisciplinary Sciences

Limited distribution and mechanism of the TetX4 tetracycline resistance enzyme

Yongchang Xu et al.

SCIENCE BULLETIN (2019)

添加到收藏夹
Article Microbiology

An overview of tetracyclines and related resistance mechanisms

Elham Sheykhsaran et al.

REVIEWS IN MEDICAL MICROBIOLOGY (2019)

添加到收藏夹
Article Immunology

Plasmid-mediated tigecycline-resistant gene tet(X4) in Escherichia coli from food-producing animals, China, 2008?2018

Chengtao Sun et al.

EMERGING MICROBES & INFECTIONS (2019)

添加到收藏夹
Article Immunology

Emergence of mobile tigecycline resistance mechanism in Escherichia coli strains from migratory birds in China

Chong Chen et al.

EMERGING MICROBES & INFECTIONS (2019)

添加到收藏夹
Review Environmental Sciences

Review of antibiotic resistance in China and its environment

Min Qiao et al.

ENVIRONMENT INTERNATIONAL (2018)

添加到收藏夹
Review Biochemistry & Molecular Biology

Antibiotic Use in Agriculture and Its Consequential Resistance in Environmental Sources: Potential Public Health Implications

Christy Manyi-Loh et al.

MOLECULES (2018)

添加到收藏夹
Article Microbiology

Various Profiles of tet Genes Addition to tet(X) in Riemerella anatipestifer Isolates From Ducks in China

De-Kang Zhu et al.

FRONTIERS IN MICROBIOLOGY (2018)

添加到收藏夹
Review Microbiology

Mobile Genetic Elements Associated with Antimicrobial Resistance

Sally R. Partridge et al.

CLINICAL MICROBIOLOGY REVIEWS (2018)

添加到收藏夹
Review Infectious Diseases

Once daily high dose tigecycline - pharmacokinetic/pharmacodynamic based dosing for optimal clinical effectiveness: dosing matters, revisited

Burke A. Cunha et al.

EXPERT REVIEW OF ANTI-INFECTIVE THERAPY (2017)

添加到收藏夹
Article Immunology

Efflux Pump Overexpression Contributes to Tigecycline Heteroresistance in Salmonella enterica serovar Typhimurium

Yi Chen et al.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2017)

添加到收藏夹
Review Zoology

The role of wildlife (wild birds) in the global transmission of antimicrobial resistance genes

Jing Wang et al.

ZOOLOGICAL RESEARCH (2017)

添加到收藏夹
Article Microbiology

Potential of Tetracycline Resistance Proteins To Evolve Tigecycline Resistance

Marius Linkevicius et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2016)

添加到收藏夹
Review Biotechnology & Applied Microbiology

Antibiotic resistance in urban aquatic environments: can it be controlled?

Celia M. Manaia et al.

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2016)

添加到收藏夹
Article Engineering, Environmental

Residual veterinary antibiotics in pig excreta after oral administration of sulfonamides

Jinrong Qiu et al.

ENVIRONMENTAL GEOCHEMISTRY AND HEALTH (2016)

添加到收藏夹
Review Pharmacology & Pharmacy

The rapid spread of carbapenem-resistant Enterobacteriaceae

Robert F. Potter et al.

DRUG RESISTANCE UPDATES (2016)

添加到收藏夹
Review Environmental Sciences

The urgent need for risk assessment on the antibiotic resistance spread via sewage sludge land application

Kinga Bondarczuk et al.

ENVIRONMENT INTERNATIONAL (2016)

添加到收藏夹
Article Infectious Diseases

Abrp, a new gene, confers reduced susceptibility to tetracycline, glycylcine, chloramphenicol and fosfomycin classes in Acinetobacter baumannii

X. Li et al.

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES (2016)

添加到收藏夹
Article Microbiology

Dissemination and Mechanism for the MCR-1 Colistin Resistance

Rongsui Gao et al.

PLOS PATHOGENS (2016)

添加到收藏夹
Article Multidisciplinary Sciences

Step-Wise Increase in Tigecycline Resistance in Klebsiella pneumoniae Associated with Mutations in ramR, lon and rpsJ

Li Fang et al.

PLOS ONE (2016)

添加到收藏夹
Article Microbiology

Mechanisms of Antibiotic Resistance

Jose M. Munita et al.

MICROBIOLOGY SPECTRUM (2016)

添加到收藏夹
Article Microbiology

The Ribosomal S10 Protein Is a General Target for Decreased Tigecycline Susceptibility

Kathryn Beabout et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2015)

添加到收藏夹
Review Microbiology

Fighting antibiotic resistance in the intensive care unit using antibiotics

Nienke L. Plantinga et al.

FUTURE MICROBIOLOGY (2015)

添加到收藏夹
Article Medicine, General & Internal

Antibiotic resistance: are we all doomed?

P. Collignon

INTERNAL MEDICINE JOURNAL (2015)

添加到收藏夹
Article Infectious Diseases

Induced tigecycline resistance in Streptococcus pneumoniae mutants reveals mutations in ribosomal proteins and rRNA

Andreanne Lupien et al.

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2015)

添加到收藏夹
Article Multidisciplinary Sciences

Global trends in antimicrobial use in food animals

Thomas P. Van Boeckel et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

添加到收藏夹
Article Microbiology

Insertion Sequence IS26 Reorganizes Plasmids in Clinically Isolated Multidrug-Resistant Bacteria by Replicative Transposition

Susu He et al.

MBIO (2015)

添加到收藏夹
Article Microbiology

RND-type drug efflux pumps from Gram-negative bacteria: molecular mechanism and inhibition

Henrietta Venter et al.

FRONTIERS IN MICROBIOLOGY (2015)

添加到收藏夹
Article Microbiology

Genomic Analysis of Reduced Susceptibility to Tigecycline in Enterococcus faecium

Vincent Cattoir et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2015)

添加到收藏夹
Article Infectious Diseases

Tigecycline resistance in Acinetobacter baumannii mediated by frameshift mutation in plsC, encoding 1-acyl-sn-glycerol-3-phosphate acyltransferase

X. Li et al.

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES (2015)

添加到收藏夹
Review Pharmacology & Pharmacy

Tigecycline: a critical safety review

Quanhathai Kaewpoowat et al.

EXPERT OPINION ON DRUG SAFETY (2015)

添加到收藏夹
Article Microbiology

Transformation of tetracycline by TetX and its subsequent degradation in a heterologous host

Sudeshna Ghosh et al.

FEMS MICROBIOLOGY ECOLOGY (2015)

添加到收藏夹
Article Food Science & Technology

Meat consumption: Trends and quality matters

Maeve Henchion et al.

MEAT SCIENCE (2014)

添加到收藏夹
Article Multidisciplinary Sciences

First Emergence of acrAB and oqxAB Mediated Tigecycline Resistance in Clinical Isolates of Klebsiella pneumoniae Pre-Dating the Use of Tigecycline in a Chinese Hospital

Xue Zhong et al.

PLOS ONE (2014)

添加到收藏夹
Article Microbiology

Shotgun metagenomics reveals a wide array of antibiotic resistance genes and mobile elements in a polluted lake in India

Johan Bengtsson-Palme et al.

Frontiers in Microbiology (2014)

添加到收藏夹
Review Microbiology

Bacterial diversity and antibiotic resistance in water habitats: searching the links with the human microbiome

Ivone Vaz-Moreira et al.

FEMS MICROBIOLOGY REVIEWS (2014)

添加到收藏夹
Review Immunology

The Scourge of Antibiotic Resistance: The Important Role of the Environment

Rita L. Finley et al.

CLINICAL INFECTIOUS DISEASES (2013)

添加到收藏夹
Review Infectious Diseases

Tigecycline: an update

Gary E. Stein et al.

DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE (2013)

添加到收藏夹
Article Infectious Diseases

The tetA gene decreases tigecycline sensitivity of Salmonella enterica isolates

Tatsuya Akiyama et al.

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS (2013)

添加到收藏夹
Article Infectious Diseases

Multidrug-resistant tet(X)-containing hospital isolates in Sierra Leone

Tomasz A. Leski et al.

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS (2013)

添加到收藏夹
Review Infectious Diseases

Antibiotic resistance amongst healthcare-associated pathogens in China

Saber Yezli et al.

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS (2012)

添加到收藏夹
Article Biochemistry & Molecular Biology

Structural basis for a new tetracycline resistance mechanism relying on the TetX monooxygenase

Gesa Volkers et al.

FEBS LETTERS (2011)

添加到收藏夹
Review Infectious Diseases

Efficacy and safety of tigecycline: a systematic review and meta-analysis

Dafna Yahav et al.

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2011)

添加到收藏夹
Review Microbiology

Horizontal gene exchange in environmental microbiota

Rustam I. Aminov

FRONTIERS IN MICROBIOLOGY (2011)

添加到收藏夹
Article Microbiology

Combined ramR Mutation and Presence of a Tn1721-Associated tet(A) Variant in a Clinical Isolate of Salmonella enterica Serovar Hadar Resistant to Tigecycline

M. Hentschke et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2010)

添加到收藏夹
Review Biochemistry & Molecular Biology

The tetracycline resistome

Maulik Thaker et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2010)

添加到收藏夹
Review Microbiology

Call of the wild: antibiotic resistance genes in natural environments

Heather K. Allen et al.

NATURE REVIEWS MICROBIOLOGY (2010)

添加到收藏夹
Review Microbiology

Origins and Evolution of Antibiotic Resistance

Julian Davies et al.

MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS (2010)

添加到收藏夹
Article Microbiology

ISCR2, Another Vehicle for blaVEB Gene Acquisition

Laurent Poirel et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2009)

添加到收藏夹
Article Infectious Diseases

AdeABC multidrug efflux pump is associated with decreased susceptibility to tigecycline in Acinetobacter calcoaceticus-Acinetobacter baumannii complex

Alexey Ruzin et al.

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2007)

添加到收藏夹
Review Environmental Sciences

Potential ecological and human health impacts of antibiotics and antibiotic-resistant bacteria from wastewater treatment plants

Sungpyo Kim et al.

JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS (2007)

添加到收藏夹
Article Microbiology

Functional, biophysical, and structural bases for antibacterial activity of tigecycline

Matthew W. Olson et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2006)

添加到收藏夹
Article Biochemistry & Molecular Biology

Expression and regulation of 1-acyl-sn-glycerol-3-phosphate acyltransferases in the epidermis

B Lu et al.

JOURNAL OF LIPID RESEARCH (2005)

添加到收藏夹
Article Biotechnology & Applied Microbiology

Fresh from the pipeline - Tigecycline

R Wenzel et al.

NATURE REVIEWS DRUG DISCOVERY (2005)

添加到收藏夹
Article Infectious Diseases

Tigecycline: what is it, and where should it be used?

DM Livermore

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2005)

添加到收藏夹
Article Biochemistry & Molecular Biology

Tigecycline is modified by the flavin-dependent monooxygenase TetX

IF Moore et al.

BIOCHEMISTRY (2005)

添加到收藏夹
Article Microbiology

Presence of tetracycline resistance determinants and susceptibility to tigecycline and minocycline

AC Fluit et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2005)

添加到收藏夹
Article Biochemistry & Molecular Biology

TetX is a flavin-dependent monooxygenase conferring resistance to tetracycline antibiotics

WR Yang et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)

添加到收藏夹
Article Immunology

Tetracycline therapy: Update

MC Roberts

CLINICAL INFECTIOUS DISEASES (2003)

添加到收藏夹
Review Pharmacology & Pharmacy

New developments in tetracycline antibiotics: glycylcyclines and tetracycline efflux pump inhibitors

I Chopra

DRUG RESISTANCE UPDATES (2002)

添加到收藏夹
Review Microbiology

Tetracycline antibiotics: Mode of action, applications, molecular biology, and epidemiology of bacterial resistance

I Chopra et al.

MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS (2001)

添加到收藏夹
研讨会 海报 问题 讨论圈 基金 期刊 论文 科研社交 资讯集成 审稿人 关于我们 常见问题 移动App 隐私条款 使用条款
© Peeref 2019-2024. All rights reserved.