4.6 Article

In vitro evaluation of the antimicrobial activity of antiseptics against clinical Acinetobacter baumannii strains isolated from combat wounds

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Immunology

Characterization of reduced susceptibility to chlorhexidine among Gram-negative bacteria

Tamar Leshem et al.

Summary: This study examines the chlorhexidine gluconate (CHG) susceptibility among Gram-negative strains in Israel and explores factors that may affect this susceptibility. The results show that ESBL-positive bacteria have lower susceptibility to CHG, and bacteria in sputum, wounds, and body fluids are also less susceptible to CHG.

MICROBES AND INFECTION (2022)

Article Urology & Nephrology

Anti-Biofilm Effect of Octenidine and Polyhexanide on Uropathogenic Biofilm-Producing Bacteria

Maria Loose et al.

Summary: The study found that antiseptics containing octenidine and polyhexanide have a broad effect against uropathogenic biofilm producers, even in high dilutions. This provides a basis for further investigation of the potential of octenidine and polyhexanide as prophylaxis or treatment of catheter biofilms.

UROLOGIA INTERNATIONALIS (2021)

Article Biochemistry & Molecular Biology

In Vitro Evaluation of Polihexanide, Octenidine and NaClO/HClO-Based Antiseptics against Biofilm Formed by Wound Pathogens

Grzegorz Krasowski et al.

Summary: This study compared the antibiofilm activity of different antiseptics, finding that polyhexanide- and octenidine-based antiseptics had high antibiofilm activity, while hypochlorite-based antiseptics showed weaker effects. The data suggest that polyhexanide- or octenidine-based antiseptics are highly useful in treating biofilm.

MEMBRANES (2021)

Article Dermatology

Octenidine dihydrochloride treatment of a meticillin-resistant Staphylococcus aureus biofilm-infected mouse wound

Jianhua Huang et al.

Summary: The study demonstrated that liquid octenidine dihydrochloride dressing can accelerate wound healing, reduce MRSA infection, lower inflammatory cell burden, and destroy biofilm structure.

JOURNAL OF WOUND CARE (2021)

Article Infectious Diseases

Combination inhibition activity of chlorhexidine and antibiotics on multidrug-resistant Acinetobacter baumannii in vitro

Fei Lin et al.

Summary: The study demonstrated that the combination of chlorhexidine with antibiotics could be used to control the risk of infection with A. baumannii, showing synergistic and additive effects.

BMC INFECTIOUS DISEASES (2021)

Article Microbiology

Human Pleural Fluid and Human Serum Albumin Modulate the Behavior of a Hypervirulent and Multidrug-Resistant (MDR) Acinetobacter baumannii Representative Strain

Camila Pimentel et al.

Summary: Acinetobacter baumannii, a nosocomial pathogen with high antibiotic resistance, has been shown to adapt to different host environments, providing insights into potential novel antimicrobial strategies. Research on the gene expression profile of A. baumannii when exposed to human fluids revealed key pathways involved in the pathogen's response.

PATHOGENS (2021)

Article Infectious Diseases

Reduced Susceptibility to Chlorhexidine among Staphylococcus aureus Isolates in Israel: Phenotypic and Genotypic Tolerance

Maya Azrad et al.

Summary: This study investigated the prevalence of chlorhexidine gluconate (CHG) tolerance among S. aureus strains in Israel, finding 13.15% of isolates to be CHG-tolerant. An association between phenotypic and genotypic tolerance to CHG was observed, with phenotypic tolerance being associated with methicillin resistance but not with mupirocin resistance. Most CHG-tolerant strains were isolated from blood cultures, indicating their prevalence in invasive infections. Further research is needed to evaluate risk factors for the development of CHG tolerance.

ANTIBIOTICS-BASEL (2021)

Review Biochemistry & Molecular Biology

Multidrug-resistant Acinetobacter baumannii as an emerging concern in hospitals

Susan Ibrahim et al.

Summary: Acinetobacter baumannii has become a major concern in the scientific community due to its extensive antimicrobial resistance. The acquisition of mobile genetic elements has led to the prevalence of multidrug-resistant strains, including carbapenem-resistant A. baumannii (CR-Ab), which is a worldwide problem. Plasmid-mediated resistance has caused outbreaks of extensively drug-resistant A. baumannii (XDR-Ab), highlighting the importance of proper monitoring, prevention, and treatment to control infections.

MOLECULAR BIOLOGY REPORTS (2021)

Article Multidisciplinary Sciences

Subtypes, resistance and virulence platforms in extended-drug resistant Acinetobacter baumannii Romanian isolates

Irina Gheorghe et al.

Summary: This study reports the resistome and virulome of 33 extended drug-resistant and carbapenem-resistant Acinetobacter baumannii strains from patients in Bucharest, Romania. The isolates were found to be extensively drug-resistant, with high diversity in resistance genes and sequence types. The data can help understand the characteristics of these XDR AB isolates, support the implementation of infection control measures, and contribute to the development of new treatments.

SCIENTIFIC REPORTS (2021)

Article Multidisciplinary Sciences

Chimeric vaccine designs against Acinetobacter baumannii using pan genome and reverse vaccinology approaches

Fatima Shahid et al.

Summary: A. baumannii has become a focus of medical research due to its ability to cause nosocomial infections, evolving immune evasion strategies, and increased drug resistance. The study aims to explore novel therapeutic alternatives through computational frameworks to identify core vaccine candidates and design chimeric vaccine constructs.

SCIENTIFIC REPORTS (2021)

Article Biology

A novel decoy strategy for polymyxin resistance in Acinetobacter baumannii

Jaeeun Park et al.

Summary: The modification of outer membrane charge induced by polymyxin B (PMB) in Acinetobacter baumannii leads to PMB-resistant variants and clinical isolates producing outer membrane vesicles (OMVs). Upregulation of the pmr operon and decreased membrane-linkage proteins result in enhanced biofilm formation and protection of susceptible bacteria from PMB, suggesting OMVs function as decoys against PMB. OMVs also protect the microbial community against PMB treatment in anaerobic conditions, indicating their potential clinical significance in antibiotic resistance.
Article Public, Environmental & Occupational Health

Ability of chlorhexidine, octenidine, polyhexanide and chloroxylenol to inhibit metabolism of biofilm-forming clinical multidrug-resistant organisms

Frank Guenther et al.

Summary: In this in vitro study, standard antiseptics were tested for their ability to disrupt the metabolic activity of multidrug-resistant bacteria within biofilms. Chlorhexidine gluconate and octenidine showed the greatest efficacy, particularly against MRSA, while polyhexanide and chloroxylenol were less effective compared to chlorhexidine gluconate and octenidine.

JOURNAL OF INFECTION PREVENTION (2021)

Review Infectious Diseases

Antimicrobial stewardship of antiseptics that are pertinent to wounds: the need for a united approach

Jean-Yves Maillard et al.

Summary: This review discusses the challenges faced in wound care due to the emergence of antibiotic-resistant strains, the tolerance of biofilms to antibiotics, and reported resistance to non-antibiotic antimicrobials. It also highlights the lack of standardized methods for evaluating the efficacy of antimicrobial dressings, as well as the difficulties in surveillance and management. The review calls for a unified approach to developing standardized methods that will provide a better basis for practitioners to make informed choices in wound care.

JAC-ANTIMICROBIAL RESISTANCE (2021)

Article Otorhinolaryngology

Effects of povidone-iodine composite on the elimination of bacterial biofilm

Leonita Pinto Jeronimo et al.

INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY (2020)

Article Infectious Diseases

Synergistic effect between nisin and polymyxin B against pandrug-resistant and extensively drug-resistant Acinetobacter baumannii

Varsha M. Thomas et al.

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS (2019)

Article Materials Science, Biomaterials

World Health Organization Report: Current Crisis of Antibiotic Resistance

Amin Talebi Bezmin Abadi et al.

BIONANOSCIENCE (2019)

Article Environmental Sciences

Antibiotic Resistance of Acinetobacter spp. Isolates from the River Danube: Susceptibility Stays High

Clemens Kittinger et al.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2018)

Review Infectious Diseases

Health care-associated infections - an overview

Mainul Haque et al.

INFECTION AND DRUG RESISTANCE (2018)

Article Dermatology

Povidone-iodine ointment demonstrates in vitro efficacy against biofilm formation

Matthias J. Hoekstra et al.

INTERNATIONAL WOUND JOURNAL (2017)

Article Infectious Diseases

In vitro activity of a-polyhexanide-betaine solution against high-risk clones of multidrug-resistant nosocomial pathogens

Rafael Lopez-Rojas et al.

ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA (2017)

Article Infectious Diseases

Antimicrobial activity of octenidine against multidrug-resistant Gram-negative pathogens

R. Alvarez-Marin et al.

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES (2017)

Article Dentistry, Oral Surgery & Medicine

Chlorhexidine with or without alcohol against biofilm formation: efficacy, adverse events and taste preference

Gabriela Otero dos Santos et al.

BRAZILIAN ORAL RESEARCH (2017)

Article Public, Environmental & Occupational Health

In vitro evaluation of the susceptibility of Acinetobacter baumannii isolates to antiseptics and disinfectants: comparison between clinical and environmental isolates

Sanae Lanjri et al.

ANTIMICROBIAL RESISTANCE AND INFECTION CONTROL (2017)

Article Microbiology

Colistin-Resistant Acinetobacter baumannii Clinical Strains with Deficient Biofilm Formation

Konstantina Dafopoulou et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2016)

Article Microbiology

Dental plaque bacteria with reduced susceptibility to chlorhexidine are multidrug resistant

Hafiz Ghulam Murtaza Saleem et al.

BMC MICROBIOLOGY (2016)

Article Tropical Medicine

Biofilm formation in clinical isolates of nosocomial Acinetobacter baumannii and its relationship with multidrug resistance

Ebrahim Babapour et al.

ASIAN PACIFIC JOURNAL OF TROPICAL BIOMEDICINE (2016)

Article Microbiology

Antibiofilm Effect of Octenidine Hydrochloride on Staphylococcus aureus, MRSA and VRSA

Mary Anne Roshni Amalaradjou et al.

PATHOGENS (2014)

Review Infectious Diseases

Emergence of resistance to carbapenems in Acinetobacter baumannii in Europe: clinical impact and therapeutic options

Marie Kempf et al.

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS (2012)

Article Dentistry, Oral Surgery & Medicine

Antimicrobial Efficacy of Chlorhexidine against Bacteria in Biofilms at Different Stages of Development

Ya Shen et al.

JOURNAL OF ENDODONTICS (2011)

Article Orthopedics

Multidrug-resistant organisms in military wounds from iraq and afghanistan

Jason H. Calhoun et al.

CLINICAL ORTHOPAEDICS AND RELATED RESEARCH (2008)

Article Genetics & Heredity

Comparative genomics of multidrug resistance in Acinetobacter baumannii

Pierre-Edouard Fournier et al.

PLOS GENETICS (2006)