期刊
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
卷 12, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fcimb.2022.938608
关键词
Helicobacter pylori; gastrointestinal microecology; probiotics; infection; eradication
资金
- National Natural Science Foundation of China
- Zhejiang Provincial Natural Science Foundation of China
- Health Science and Technology Plan Project of Zhejiang Province
- [82100600]
- [LQ20H030009]
- [2018KY367]
The prevalence of H. pylori infection is high worldwide and is associated with various digestive system diseases. H. pylori infection alters the gastrointestinal microflora and contributes to the development of tumors and extragastrointestinal diseases. Probiotics can improve the efficacy of H. pylori eradication therapy by reducing intestinal flora imbalances.
The prevalence of Helicobacter pylori (H. pylori) infection has exceeded 50% worldwide, and it is considered a high-risk factor for chronic gastritis, peptic ulcer, gastric adenocarcinoma, gastroesophageal reflux disease and functional dyspepsia. H. pylori drug resistance is a common problem worldwide. In recent years, the relationship between H. pylori infection and gastrointestinal microecology has received much attention. H. pylori infection changes the structure and composition of gastrointestinal microflora by regulating the gastrointestinal microecological environment, local pH value, cytokines and antimicrobial peptides, and immune response and then plays a crucial role in the occurrence and development of digestive system tumors, liver metabolism and extragastrointestinal diseases. The quadruple strategy of H. pylori eradication can also aggravate gastrointestinal microflora disorder. However, probiotics can reduce intestinal flora changes and imbalances through different mechanisms, thus enhancing the efficacy of H. pylori eradication therapy and reducing adverse reactions caused by eradication therapy. Therefore, this paper reviews the relationship between H. pylori infection and gastrointestinal microecology and its clinical application, providing a basis for clinical treatment.
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