Clinical performance of metagenomic next-generation sequencing for the rapid diagnosis of talaromycosis in HIV-infected patients

Article Mycology

Talaromyces marneffei Mp1p Antigen Detection may Play an Important Role in the Early Diagnosis of Talaromycosis in Patients with Acquired Immunodeficiency Syndrome

Chen Xiaoman et al.

Summary: Talaromycosis is a life-threatening fungal disease commonly seen in AIDS patients. The Mp1p enzyme immunoassay can assist in early diagnosis, especially in patients with low CD4+ cell counts.

MYCOPATHOLOGIA (2022)

添加到收藏夹

Article Medicine, General & Internal

Clinical Characteristics, Laboratory Findings, and Prognosis in Patients With Talaromyces marneffei Infection Across Various Immune Statuses

Dianwu Li et al.

Summary: This study retrospectively analyzed the clinical features and prognosis of patients with Talaromyces marneffei (TM) infection, comparing HIV-positive and negative patients. The results showed that HIV-positive patients were more likely to develop disseminated TM, resulting in higher mortality rates. Patients without HIV but with immunocompromised conditions had similar hospital mortality rates compared to immunocompetent patients, but required longer hospitalization for recovery.

FRONTIERS IN MEDICINE (2022)

添加到收藏夹

Article Immunology

Superiority of a Novel Mp1p Antigen Detection Enzyme Immunoassay Compared to Standard BACTEC Blood Culture in the Diagnosis of Talaromycosis

Nguyen T. M. Thu et al.

Summary: The study assessed the accuracy of Mp1p antigen-detecting enzyme immunoassay in diagnosing talaromycosis, showing high specificity and sensitivity compared to blood culture. Additionally, paired plasma and urine testing significantly increased sensitivity, providing a new tool for rapid diagnosis and potentially reducing mortality rates.

CLINICAL INFECTIOUS DISEASES (2021)

添加到收藏夹

Article Infectious Diseases

The diagnostic value of metagenomic next-generation sequencing in infectious diseases

Hongxia Duan et al.

Summary: The study found that mNGS had a higher sensitivity than the traditional method, especially in blood, bronchoalveolar lavage fluid and sputum samples. The positive mNGS group had a higher hospital stay and 28-day mortality, with age being significant in multivariate logistic analyses of positive results of mNGS.

BMC INFECTIOUS DISEASES (2021)

添加到收藏夹

Article Infectious Diseases

Metagenomic next-generation sequencing for the diagnosis of suspected pneumonia in immunocompromised patients

Jin-Min Peng et al.

Summary: The study evaluated the potential of mNGS for immunocompromised patients with suspected pneumonia and found that while mNGS and CMTs had similar diagnostic accuracy for bacterial and viral infections, mNGS had lower accuracy for fungal infections. The combination of mNGS and CMTs may be the best diagnostic strategy.

JOURNAL OF INFECTION (2021)

添加到收藏夹

Article Infectious Diseases

Gastrointestinal manifestations of Talaromyces marneffei infection in an HIV-infected patient rapidly verified by metagenomic next-generation sequencing: a case report

Ying Zhou et al.

Summary: Atypical manifestations of Talaromyces marneffei infection in some HIV-infected patients, rare cases with gastrointestinal involvement, and the challenge of diagnosis without characteristic symptoms are highlighted. The use of metagenomic next-generation sequencing with formalin-fixation and paraffin-embedded samples for diagnosis is emphasized.

BMC INFECTIOUS DISEASES (2021)

添加到收藏夹

Article Medicine, General & Internal

Case Report: Metagenomic Next-Generation Sequencing in Diagnosis of Talaromycosis of an Immunocompetent Patient

Jiejun Shi et al.

Summary: When broad-spectrum antibiotics do not work in immunocompetent patients, the possibility of opportunistic fungal infections should be considered. Metagenomic Next-Generation Sequencing (mNGS) can detect pathogenic bacteria faster than traditional methods, providing important help for clinical decision-making.

FRONTIERS IN MEDICINE (2021)

添加到收藏夹

Article Infectious Diseases

Metagenomic next-generation sequencing for the early diagnosis of talaromycosis in HIV-uninfected patients: five cases report

Qiuhua Chen et al.

Summary: Talaromycosis is reportedly increasing in HIV-uninfected patients, leading to a higher risk of misdiagnosis and mistreatment compared to HIV-infected patients. Metagenomic next-generation sequencing (mNGS) proved to be a rapid and effective approach for the early confirmation of talaromycosis, potentially reducing misdiagnosis duration and improving prognosis. Through this study, valuable insights for the early diagnosis of talaromycosis in HIV-uninfected patients with the assistance of mNGS have been provided.

BMC INFECTIOUS DISEASES (2021)

添加到收藏夹

Review Mycology

Pulmonary Talaromycosis: A Window into the Immunopathogenesis of an Endemic Mycosis

Shanti Narayanasamy et al.

Summary: Talaromycosis is an invasive mycosis caused by the fungus Talaromyces marneffei, predominantly affecting immunocompromised hosts with lung manifestations. Early diagnosis and treatment are crucial for improving survival rates.

MYCOPATHOLOGIA (2021)

添加到收藏夹

Article Infectious Diseases