4.7 Review

Implications of Porphyromonas gingivalis peptidyl arginine deiminase and gingipain R in human health and diseases

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Dentistry, Oral Surgery & Medicine

Effect of adjunctive systemic antibiotics on microbial populations compared with scaling and root planing alone for the treatment of periodontitis: A pilot randomized clinical trial

Hongye Lu et al.

Summary: Periodontitis treatment with SRP and adjunctive antibiotics led to significant clinical improvement and reduced microbial diversity within 6 months. The use of antibiotics also showed potential benefits for systemic inflammation and glucose levels.

JOURNAL OF PERIODONTOLOGY (2022)

Article Dentistry, Oral Surgery & Medicine

Association between periodontitis and Alzheimer's disease and its impact on the self-perceived oral health status: a case-control study

Raquel de Oliveira Araujo et al.

Summary: The study revealed an association between periodontitis and Alzheimer's disease, but it did not affect the patients’ oral health-related quality of life. Alzheimer's patients had fewer teeth and more severe periodontitis, but they perceived better oral health status.

CLINICAL ORAL INVESTIGATIONS (2021)

Article Biochemistry & Molecular Biology

In-silicodrug repurposing and molecular dynamics puzzled out potential SARS-CoV-2 main protease inhibitors

Mahmoud A. A. Ibrahim et al.

Summary: The DrugBank database was explored to identify potential drugs targeting the SARS-CoV-2 main protease, with DB02388 and Cobicistat showing high binding affinities and stability. Compared to Darunavir, DB02388 and Cobicistat demonstrated better potential as anti-COVID-19 drugs for clinical trials.

JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS (2021)

Article Biochemistry & Molecular Biology

DockCoV2: a drug database against SARS-CoV-2

Ting-Fu Chen et al.

Summary: The current global health crisis due to COVID-19 has prompted researchers to develop DockCoV2, a drug database that focuses on predicting the binding affinity of drugs with key proteins of SARS-CoV-2 in order to expedite the discovery of potential treatments.

NUCLEIC ACIDS RESEARCH (2021)

Article Microbiology

PPAD Activity Promotes Outer Membrane Vesicle Biogenesis and Surface Translocation by Porphyromonas gingivalis

Danielle M. Vermilyea et al.

Summary: Many bacteria can switch between sessile and motile modes in response to signals, and recent studies have shown Porphyromonas gingivalis can surface translocate. PPAD secreted by P. gingivalis promotes this process by impacting OMV biogenesis. OMVs containing enzymes like gingipains indicate PPAD's role in periodontitis and systemic diseases.

JOURNAL OF BACTERIOLOGY (2021)

Review Immunology

The Role of Porphyromonas gingivalis Outer Membrane Vesicles in Periodontal Disease and Related Systemic Diseases

Zhiying Zhang et al.

Summary: Periodontal disease is a chronic infectious disease associated with various systemic diseases, with P. gingivalis as the key pathogen producing OMVs that play an important role in disease pathogenesis.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2021)

Article Chemistry, Analytical

Washing- and Separation-Free Electrochemical Detection of Porphyromonas gingivalis in Saliva for Initial Diagnosis of Periodontitis

Seonhwa Park et al.

Summary: An electrochemical biosensor for sensitive detection of Porphyromonas gingivalis in saliva was developed without the need for washing and separation steps. This biosensor can be used as an initial diagnosis method to distinguish between healthy people and patients with periodontal diseases.

ANALYTICAL CHEMISTRY (2021)

Review Dentistry, Oral Surgery & Medicine

Outer membrane vesicles of Porphyromonas gingivalis: Novel communication tool and strategy

Hirohiko Okamura et al.

Summary: Extracellular vesicles (EVs), including bacterial Outer Membrane Vesicles (OMVs), are natural messengers involved in cell-to-cell communication within microorganism populations. OMVs carry crucial molecules, serving as a means of communication between bacteria and hosts. Different bacteria produce distinct types of OMVs with varying contents.

JAPANESE DENTAL SCIENCE REVIEW (2021)

Article Cell Biology

Porphyromonas gingivalis induces periodontitis, causes immune imbalance, and promotes rheumatoid arthritis

Niu Zhou et al.

Summary: Periodontitis induced by P. gingivalis may exacerbate collagen-induced arthritis in mice and affect the differentiation of immune cells, leading to a decrease in B10 cells, which could be a key mechanism in promoting rheumatoid arthritis.

JOURNAL OF LEUKOCYTE BIOLOGY (2021)

Article Materials Science, Biomaterials

Dynamic analysis of Porphyromonas gingivalis invasion into blood capillaries during the infection process in host tissues using a vascularized three-dimensional human gingival model

Naoko Sasaki et al.

Summary: The study revealed that the periodontal disease pathogen Porphyromonas gingivalis invades the blood capillaries via the epithelial cell layer, utilizing an intercellular pathway. Wild-type P. gingivalis showed a significant increase in bacterial numbers after two days of infection, while a mutant lacking gingipains exhibited lower survival rates. Furthermore, P. gingivalis infection disrupted the secretion of interleukin-6 (IL-6) in the early stages.

BIOMATERIALS SCIENCE (2021)

Article Dentistry, Oral Surgery & Medicine

Non-communicable Diseases and Oral Health: An Overview

Thomas Gerhard Wolf et al.

Summary: Non-communicable diseases, such as cardiovascular and metabolic diseases, diabetes, cancer, and oral diseases, pose a global and highly relevant problem due to demographic and epidemiological changes. Training interdisciplinary oral health professionals is crucial in addressing the inequities in oral health. A paradigm shift towards a public health approach at the population level is necessary to integrate different health professionals dealing with NCDs and promote overall health.

FRONTIERS IN ORAL HEALTH (2021)

Review Biochemistry & Molecular Biology

Porphyromonas gingivalis: where do we stand in our battle against this oral pathogen?

Kaitlind C. Howard et al.

Summary: Periodontal diseases are inflammatory diseases caused by pathogenic bacteria, and current antibacterial treatment options may harm beneficial bacterial species in the oral microbiome. The development of more effective and specific antibacterial agents is needed to control oral pathogens in a polymicrobial environment, including natural product isolation and synthetic methods.

RSC MEDICINAL CHEMISTRY (2021)

Article Dentistry, Oral Surgery & Medicine

Thymoquinone inhibits biofilm formation and virulence properties of periodontal bacteria

P. Tantivitayakul et al.

ARCHIVES OF ORAL BIOLOGY (2020)

Article Biochemistry & Molecular Biology

Outer membrane vesicles of Porphyromonas gingivalis attenuate insulin sensitivity by delivering gingipains to the liver

Mariko Seyama et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2020)

Review Biochemistry & Molecular Biology

Deimination, Intermediate Filaments and Associated Proteins

Julie Briot et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Biochemistry & Molecular Biology

A natural anti-periodontitis agent, epimedokoreanin B, inhibits virulence activities of gingipains from Porphyromonas gingivalis

Toru Kariu et al.

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY (2019)

Article Dentistry, Oral Surgery & Medicine

Inhibitory effects of azithromycin on the adherence ability of Porphyromonas gingivalis

Powen Kan et al.

JOURNAL OF PERIODONTOLOGY (2019)

Article Biochemistry & Molecular Biology

Isolates from Monechma ciliatum seeds' extract hampered Porphyromonas gingivalis hemagglutinins

Sara A. Eltigani et al.

JOURNAL OF FOOD BIOCHEMISTRY (2019)

Article Dentistry, Oral Surgery & Medicine

Type IX secretion system is pivotal for expression of gingipain-associated virulence of Porphyromonas gingivalis

Malgorzata Benedyk et al.

MOLECULAR ORAL MICROBIOLOGY (2019)

Article Dentistry, Oral Surgery & Medicine

Administration of systemic antibiotics during non-surgical periodontal therapya consensus report

B. Pretzl et al.

CLINICAL ORAL INVESTIGATIONS (2019)

Article Biochemistry & Molecular Biology

PubChem 2019 update: improved access to chemical data

Sunghwan Kim et al.

NUCLEIC ACIDS RESEARCH (2019)

Review Microbiology

Possible role of Porphyromonas gingivalis in orodigestive cancers

Ingar Olsen et al.

JOURNAL OF ORAL MICROBIOLOGY (2019)

Review Dentistry, Oral Surgery & Medicine

Porphyromonas gingivalis, Periodontal and Systemic Implications: A Systematic Review

Luca Fiorillo et al.

DENTISTRY JOURNAL (2019)

Article Pharmacology & Pharmacy

Inhibition of gingipains prevents Porphyromonas gingivalis-induced preterm birth and fetal death in pregnant mice

Ryosuke Takii et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2018)

Article Dentistry, Oral Surgery & Medicine

Lipoprotein modifications by gingipains of Porphyromonas gingivalis

J. Lonn et al.

JOURNAL OF PERIODONTAL RESEARCH (2018)

Article Immunology

Maturation of the Mfa1 Fimbriae in the Oral Pathogen Porphyromonas gingivalis

Jae Y. Lee et al.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2018)

Article Dentistry, Oral Surgery & Medicine

Inhibition of gingipains and Porphyromonas gingivalis growth and biofilm formation by prenyl flavonoids

T. Kariu et al.

JOURNAL OF PERIODONTAL RESEARCH (2017)

Article Dentistry, Oral Surgery & Medicine

Oral application of a periodontal pathogen impacts SerpinE1 expression and pancreatic islet architecture in prediabetes

V. Ilievski et al.

JOURNAL OF PERIODONTAL RESEARCH (2017)

Article Multidisciplinary Sciences

Microglia-derived ASC specks cross-seed amyloid-β in Alzheimer's disease

Carmen Venegas et al.

NATURE (2017)

Article Multidisciplinary Sciences

Arthritic role of Porphyromonas gingivalis in collagen-induced arthritis mice

Hyerin Jung et al.

PLOS ONE (2017)

Review Dentistry, Oral Surgery & Medicine

Novel function of Porphyromonas gingivalis gingipains in the PI3K/Akt signaling pathway

Masaaki Nakayama et al.

JOURNAL OF ORAL BIOSCIENCES (2017)

Article Neurosciences

In silico repurposing of antipsychotic drugs for Alzheimer's disease

Shivani Kumar et al.

BMC NEUROSCIENCE (2017)

Article Dentistry, Oral Surgery & Medicine

Green tea catechins potentiate the effect of antibiotics and modulate adherence and gene expression in Porphyromonas gingivalis

Jade Fournier-Larente et al.

ARCHIVES OF ORAL BIOLOGY (2016)

Review Medicine, Research & Experimental

Apoptosis in pancreatic beta-islet cells in Type 2 diabetes

Tatsuo Tomita

BOSNIAN JOURNAL OF BASIC MEDICAL SCIENCES (2016)

Article Immunology

Porphyromonas gingivalis infection exacerbates the onset of rheumatoid arthritis in SKG mice

M. Yamakawa et al.

CLINICAL AND EXPERIMENTAL IMMUNOLOGY (2016)

Review Immunology

The T helper type 17/regulatory T cell paradigm in pregnancy

Ana Sofia Figueiredo et al.

IMMUNOLOGY (2016)

Article Dentistry, Oral Surgery & Medicine

Effect of deletion of the rgpA gene on selected virulence of Porphyromonas gingivalis

Rui Zhang et al.

JOURNAL OF DENTAL SCIENCES (2016)

Article Biochemical Research Methods

Extracellular Proteome and Citrullinome of the Oral Pathogen Porphyromonas gingivalis

Tim Stobernack et al.

JOURNAL OF PROTEOME RESEARCH (2016)

Article Multidisciplinary Sciences

Zebrafish as a new model to study effects of periodontal pathogens on cardiovascular diseases

Magdalena Widziolek et al.

SCIENTIFIC REPORTS (2016)

Article Chemistry, Medicinal

ZINC 15-Ligand Discovery for Everyone

Teague Sterling et al.

JOURNAL OF CHEMICAL INFORMATION AND MODELING (2015)

Article Multidisciplinary Sciences

Dental Infection of Porphyromonas gingivalis Induces Preterm Birth in Mice

Min Ao et al.

PLOS ONE (2015)

Article Dentistry, Oral Surgery & Medicine

Antibodies produced in vitro in the detection of periodontal bacteria by using surface plasmon resonance analysis

Sravya Sowdamini Nakka et al.

CLINICAL AND EXPERIMENTAL DENTAL RESEARCH (2015)

Article Biochemistry & Molecular Biology

Structure and Mechanism of Cysteine Peptidase Gingipain K (Kgp), a Major Virulence Factor of Porphyromonas gingivalis in Periodontitis

Inaki de Diego et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2014)

Article Dentistry, Oral Surgery & Medicine

Inhibitory effects of sword bean extract on alveolar bone resorption induced in rats by Porphyromonas gingivalis infection

Y. Nakatsuka et al.

JOURNAL OF PERIODONTAL RESEARCH (2014)

Article Biochemistry & Molecular Biology

Oral Porphyromonas gingivalis translocates to the liver and regulates hepatic glycogen synthesis through the Akt/GSK-3β signaling pathway

Makoto Ishikawa et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2013)

Article Integrative & Complementary Medicine

Inhibitory Effect of Dodonaea viscosa var. angustifolia on the Virulence Properties of the Oral Pathogens Streptococcus mutans and Porphyromonas gingivalis

Mrudula Patel et al.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2013)

Article Biochemistry & Molecular Biology

Porphyromonas gingivalis Virulence Factor Gingipain RgpB Shows a Unique Zymogenic Mechanism for Cysteine Peptidases

Inaki de Diego et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2013)

Review Microbiology

Porphyromonas gingivalis: an invasive and evasive opportunistic oral pathogen

Nagihan Bostanci et al.

FEMS MICROBIOLOGY LETTERS (2012)

Review Microbiology

GINGIPAINS FROM PORPHYROMONAS GINGIVALIS - COMPLEX DOMAIN STRUCTURES CONFER DIVERSE FUNCTIONS

N. Li et al.

EUROPEAN JOURNAL OF MICROBIOLOGY AND IMMUNOLOGY (2011)

Article Biochemistry & Molecular Biology

Cysteine 351 is an essential nucleophile in catalysis by Porphyromonas gingivalis peptidylarginine deiminase

Sofia B. Rodriguez et al.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2010)

Review Microbiology

The gingipains: scissors and glue of the periodontal pathogen, Porphyromonas gingivalis

Rebecca E. Fitzpatrick et al.

FUTURE MICROBIOLOGY (2009)

Article Biochemistry & Molecular Biology

ChemBank: a small-molecule screening and cheminformatics resource database

Kathleen Petri Seiler et al.

NUCLEIC ACIDS RESEARCH (2008)

Article Dentistry, Oral Surgery & Medicine

Inhibitory effect of cranberry polyphenol on biofilm formation and cysteine proteases of Porphyromonas gingivalis

A. Yamanaka et al.

JOURNAL OF PERIODONTAL RESEARCH (2007)

Article Dentistry, Oral Surgery & Medicine

Activity of anti-Porphyromonas gingivalis egg yolk antibody against gingipains in vitro

K. Yokoyama et al.

ORAL MICROBIOLOGY AND IMMUNOLOGY (2007)

Article Dentistry, Oral Surgery & Medicine

Inhibition of Porphyromonas gingivalis proteinases (gingipains) by chlorhexidine:: synergistic effect of Zn(II)

C. A. Cronan et al.

ORAL MICROBIOLOGY AND IMMUNOLOGY (2006)

Article Clinical Neurology

Extensive involvement of autophagy in Alzheimer disease: An immuno-electron microscopy study

RA Nixon et al.

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2005)

Article Dentistry, Oral Surgery & Medicine

Inhibitory effect of green tea catechins on cysteine proteinases in Porphyromonas gingivalis

M Okamoto et al.

ORAL MICROBIOLOGY AND IMMUNOLOGY (2004)

Review Biochemistry & Molecular Biology

Suppression of virulence of Porphyromonas gingivalis by potent inhibitors specific for gingipains

T Kadowaki et al.

CURRENT PROTEIN & PEPTIDE SCIENCE (2003)

Article Microbiology

The collagenase activity of Porphyromonas gingivalis is due to Arg-gingipain

MA Houle et al.

FEMS MICROBIOLOGY LETTERS (2003)

Article Dentistry, Oral Surgery & Medicine

The role of gingipains in the pathogenesis of periodontal disease

T Imamura

JOURNAL OF PERIODONTOLOGY (2003)

Review Biochemistry & Molecular Biology

Principles of docking: An overview of search algorithms and a guide to scoring functions

I Halperin et al.

PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS (2002)