期刊
ELIFE
卷 11, 期 -, 页码 -出版社
eLIFE SCIENCES PUBL LTD
DOI: 10.7554/eLife.65987
关键词
keratinocyte; touch sensation; pain; Piezo1; mechanotransduction; Mouse
类别
资金
- National Institute of Neurological Disorders and Stroke
- Medical College of Wisconsin [NS040538, NS070711, NS108278, 1F31NS125941-01]
PIEZO1 is identified as a key mechanotransducer in epidermal keratinocytes, playing a crucial role in sensory neuron activity and behavioral responses to mechanical stimuli.
Epidermal keratinocytes mediate touch sensation by detecting and encoding tactile information to sensory neurons. However, the specific mechanotransducers that enable keratinocytes to respond to mechanical stimulation are unknown. Here, we found that the mechanically-gated ion channel PIEZO1 is a key keratinocyte mechanotransducer. Keratinocyte expression of PIEZO1 is critical for normal sensory afferent firing and behavioral responses to mechanical stimuli in mice.
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