4.8 Article

An international observational study to assess the impact of the Omicron variant emergence on the clinical epidemiology of COVID-19 in hospitalised patients

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Infectious Diseases

Reduced risk of hospitalisation among reported COVID-19 cases infected with the SARS-CoV-2 Omicron BA.1 variant compared with the Delta variant, Norway, December 2021 to January 2022

Lamprini Veneti et al.

Summary: A study found that the Omicron variant of COVID-19 has a 73% reduced risk of hospitalization compared to the Delta variant. Omicron cases who had received two doses of the vaccine 7-179 days before diagnosis had a lower risk compared to Delta (66% vs 93%), while those who received three doses had a similar risk reduction (86% vs 88%).

EUROSURVEILLANCE (2022)

Letter Medicine, General & Internal

Estimates of SARS-CoV-2 Omicron Variant Severity in Ontario, Canada

Ana Cecilia Ulloa et al.

Summary: This study compares hospitalizations and deaths associated with SARS-CoV-2 Omicron variant to those of matched patients infected with the Delta variant.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2022)

Article Medicine, General & Internal

Early assessment of the clinical severity of the SARS-CoV-2 omicron variant in South Africa: a data linkage study

Nicole Wolter et al.

Summary: According to data analysis from South Africa, individuals infected with the omicron variant have a lower likelihood of hospitalization compared to those infected with non-omicron variants. Furthermore, individuals infected with the omicron variant have a lower odds of severe disease compared to individuals infected with the earlier delta variant.

LANCET (2022)

Article Multidisciplinary Sciences

Attenuated replication and pathogenicity of SARS-CoV-2 B.1.1.529 Omicron

Huiping Shuai et al.

Summary: The Omicron variant of SARS-CoV-2 shows reduced replication ability in human cells and attenuated pathogenicity in mice compared with the wild-type strain and other variants. It has lower efficiency in using TMPRSS2 and causes the lowest reduction in body weight and mortality rate among the tested strains.

NATURE (2022)

Article Multidisciplinary Sciences

Rapid epidemic expansion of the SARS-CoV-2 Omicron variant in southern Africa

Raquel Viana et al.

Summary: The SARS-CoV-2 epidemic in southern Africa has experienced three distinct waves, driven by different variants. The recently identified Omicron variant has rapidly spread in South Africa and to numerous countries, raising global concern.

NATURE (2022)

Article Multidisciplinary Sciences

SARS-CoV-2 Omicron virus causes attenuated disease in mice and hamsters

Peter J. Halfmann et al.

Summary: The recent study by the SAVE/NIAID network shows that the B.1.1.529 Omicron variant causes milder lung disease in rodents, which is consistent with preliminary human clinical data.

NATURE (2022)

Article Medicine, General & Internal

Duration of Protection against Mild and Severe Disease by Covid-19 Vaccines

Nick Andrews et al.

Summary: A study conducted in England showed that vaccines against SARS-CoV-2 provide high protection against hospitalization and death from Covid-19 at 20 weeks or more after vaccination. However, the effectiveness of the vaccines decreases over time, especially in individuals aged 65 and older and those with underlying risk factors.

NEW ENGLAND JOURNAL OF MEDICINE (2022)

Letter Medicine, General & Internal

Protection against the Omicron Variant from Previous SARS-CoV-2 Infection

Heba N. Altarawneh et al.

NEW ENGLAND JOURNAL OF MEDICINE (2022)

Article Health Care Sciences & Services

Distinguishing Admissions Specifically for COVID-19 From Incidental SARS-CoV-2 Admissions: National Retrospective Electronic Health Record Study

Jeffrey G. Klann et al.

Summary: This study aims to quantify the frequency of incidental hospitalizations during the early stage of the pandemic in multiple hospital systems in the United States and to improve COVID-19 hospitalization classification using electronic phenotyping techniques. The results showed that a large proportion of SARS-CoV-2 PCR-positive admissions were incidental, and EHR-based phenotyping methods were effective in differentiating hospitalizations.

JOURNAL OF MEDICAL INTERNET RESEARCH (2022)

Article Medicine, General & Internal

Comparative analysis of the risks of hospitalisation and death associated with SARS-CoV-2 omicron (B.1.1.529) and delta (B.1.617.2) variants in England: a cohort study

Tommy Nyberg et al.

Summary: The Omicron variant shows lower severity compared to Delta, especially in terms of hospital admission and death, with significant variations by age. Unvaccinated cases experience a larger reduction in intrinsic severity, while vaccinated cases experience reduced vaccine effectiveness. Booster vaccination with mRNA vaccines provides over 70% protection against hospitalization and death in breakthrough Omicron infections.

LANCET (2022)

Article Biochemistry & Molecular Biology

Clinical outcomes associated with SARS-CoV-2 Omicron (B.1.1.529) variant and BA.1/BA.1.1 or BA.2 subvariant infection in Southern California

Joseph A. Lewnard et al.

Summary: Comparison of outcomes of SARS-CoV-2 Delta and Omicron infections reveals reduced severity of Omicron infections, especially in unvaccinated individuals. There is no differential risk of severe outcomes between subvariants BA.1 and BA.2. Continual assessment of clinical outcomes associated with SARS-CoV-2 variants is crucial for medical interventions and healthcare resource management.

NATURE MEDICINE (2022)

Article Infectious Diseases

Admissions to a large tertiary care hospital and Omicron BA.1 and BA.2 SARS-CoV-2 polymerase chain reaction positivity: primary, contributing, or incidental COVID-19

Anne F. Voor in't Holt et al.

Summary: This study aims to assess and classify the cause of hospitalization for patients with SARS-CoV-2 Omicron variants. The results show that the majority of Omicron variant patients were primary COVID-19 cases, indicating a lower clinical severity.

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES (2022)

Article Respiratory System

Clinical characteristics, risk factors and outcomes in patients with severe COVID-19 registered in the International Severe Acute Respiratory and Emerging Infection Consortium WHO clinical characterisation protocol: a prospective, multinational, multicentre, observational study

Luis Felipe Reyes et al.

Summary: This study investigated the clinical outcomes of severe COVID-19 patients treated outside the ICU, compared to those treated in the ICU. It found that patients admitted to an ICU had a longer hospital stay and a lower 28-day fatality ratio.

ERJ OPEN RESEARCH (2022)

Article Medicine, General & Internal

Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK

Merryn Voysey et al.

Summary: The ChAdOx1 nCoV-19 vaccine has been shown to have an acceptable safety profile and effectiveness against symptomatic COVID-19, with higher efficacy observed in the group that received a low dose followed by a standard dose.

LANCET (2021)

Editorial Material Infectious Diseases

The value of open-source clinical science in pandemic response: lessons from ISARIC

LANCET INFECTIOUS DISEASES (2021)

Editorial Material Medicine, General & Internal

SARS-CoV-2 variants and ending the COVID-19 pandemic

Arnaud Fontanet et al.

LANCET (2021)

Article Biology

Ten months of temporal variation in the clinical journey of hospitalised patients with COVID-19: An observational cohort

Matthew D. Hall et al.

Summary: During the COVID-19 pandemic, there were significant variations in the nature and duration of care provided to hospitalized patients, as well as trends in ICU/HDU admission rates, hospital case fatality ratio, and total length of hospital stay. These variables may have limitations as outcome measures in rapidly evolving situations.
Article Multidisciplinary Sciences

Collider bias undermines our understanding of COVID-19 disease risk and severity

Gareth J. Griffith et al.

NATURE COMMUNICATIONS (2020)

Editorial Material Public, Environmental & Occupational Health

The Table 2 Fallacy: Presenting and Interpreting Confounder and Modifier Coefficients

Daniel Westreich et al.

AMERICAN JOURNAL OF EPIDEMIOLOGY (2013)

Editorial Material Public, Environmental & Occupational Health

Why representativeness should be avoided

Kenneth J. Rothman et al.

INTERNATIONAL JOURNAL OF EPIDEMIOLOGY (2013)