期刊
BIOMED RESEARCH INTERNATIONAL
卷 2022, 期 -, 页码 -出版社
HINDAWI LTD
DOI: 10.1155/2022/4632453
关键词
-
资金
- National Natural Science Foundation of China
- Key Research and Development Project of Chongqing's Technology Innovation and Application Development Special Big Health Field
- Doctoral Research Innovation Project of the First Affiliated Hospital of Chongqing Medical University
- [81772979]
- [CSTC2021jscx-gksb-N0027]
- [CYYY-BSYJSCXXM-202213]
CDCA3 is an essential regulator in cell mitosis and its dysregulation is common in human cancers. Our comprehensive analysis using multiple cancer-related databases and bioinformatics tools revealed that CDCA3 is overexpressed in almost all cancer types and is significantly associated with survival in multiple cancer types. CDCA3 expression positively correlates with immune cell infiltration levels in human cancers. Moreover, overexpression of CDCA3 may promote the malignant progression of cancer by activating various oncogenic signaling pathways.
CDCA3 is an essential regulator in cell mitosis and can regulate many physiological and pathological processes in the human body by stimulating certain proteins such as cell cycle regulatory proteins, transcription factors, and signal transduction molecules. Although several studies have shown that dysregulation of CDCA3 is a common phenomenon in human cancers, no systematic pan-cancer analysis has been performed. In this study, we comprehensively investigated the role of CDCA3 in 33 human cancer types by utilizing multiple cancer-related databases and bioinformatics analysis tools, including TCGA, GTEx, GEPIA, TIMER, STRING, Metascape, and Cytoscape. Evidence from bioinformatics databases shows that CDCA3 is overexpressed in almost all human cancer types, and its overexpression is significantly associated with survival in patients with more than ten cancer types. CDCA3 expression positively correlates with immune cell infiltration levels in multiple human cancer types. Furthermore, the results of the GSEA analysis revealed that overexpression of CDCA3 may promote the malignant progression of cancer by activating various oncogenic signaling pathways in human cancers. In conclusion, our pan-cancer analysis provides a comprehensive overview of the oncogenic role of CDCA3 in multiple human cancer types, suggesting that CDCA3 may serve as a potential therapeutic target and prognostic biomarker in multiple human cancer types.
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