CO2-Assisted Stereocontrolled Multi-Component Coupling Reactions Promoted by Ni-Catalytic System

A combination of Ni-catalyst and PPh3 promotes the three-component coupling reaction of vinyl epoxide, alkyne, and dimethylzinc under a carbon dioxide atmosphere to provide 2,5-heptadienyl alcohols with excellent E-stereoselectivity. The stereochemistry of the products from the multi-component coupling reaction is controlled via an oxanickelacycle intermediate, which is formed by the insertion of carbon dioxide.

Automated summary

The combination of Ni-catalyst and PPh3 promotes a three-component coupling reaction of vinyl epoxide, alkyne, and dimethylzinc under a carbon dioxide atmosphere, leading to the formation of 2,5-heptadienyl alcohols with excellent E-stereoselectivity. The stereochemistry of the products is controlled through the formation of an oxanickelacycle intermediate via the insertion of carbon dioxide.