期刊
ASIAN JOURNAL OF ORGANIC CHEMISTRY
卷 11, 期 11, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ajoc.202200515
关键词
total synthesis; asymmetric catalysis; camptothecin; alkaloids; natural product
资金
- Natural Science Foundation of Jiangsu Province [BK20220409]
- Natural Science Research of Jiangsu Higher Education Institutions of China [1020221056]
- National Natural Science Foundation of China [22001124, 22001136]
- RUDN University Strategic Academic Leadership Program
This review outlines recent advances in the asymmetric total synthesis of camptothecin, providing concise and scalable approaches for the academic community and pharmaceutical industry.
During the past decades, a variety of routes for the total synthesis of camptothecin have been reported. Considering only (S)-camptothecin and (S)-camptothecin analogues possessing the ability to inhibit DNA enzyme topoisomerase I, numerous advances have been achieved for the asymmetric total synthesis of camptothecin, providing concise and scalable approaches to (S)-camptothecin for the academic community and pharmaceutical industry. This review outlines recent advances in the asymmetric total synthesis of camptothecin, and is timely and highly desirable for the rapid development of this field. By constructing the chiral tertiary alcohol center, diverse attractive strategies have been developed for the total synthesis of (S)-camptothecin.
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