期刊
ALGAL RESEARCH-BIOMASS BIOFUELS AND BIOPRODUCTS
卷 67, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.algal.2022.102830
关键词
Alzheimer's disease; Carotenoids; Cytotoxicity; Microalgae; Neuroprotection; Pressurized liquids extraction
资金
- Bio Based Industries Joint Undertaking under the European Union (MINECO, Spain) [745668, AGL2017-89417-R]
- Spanish Ministry of Science, Innovation and Universities [IJC2018-037560-I]
- Ministry of Education (Spain) [FPU17/01876]
- University of Narino (Colombia)
- H2020 Societal Challenges Programme [745668] Funding Source: H2020 Societal Challenges Programme
Microalgae extracts enriched in carotenoids showed moderate cholinesterase inhibition potential, high antioxidant and anti-inflammatory capacities. Among the extracts, N. oceanica and T. lutea extracts exhibited the most promising neuroprotective effects.
Microalgae represent one of the most promising sources of bioactive compounds for the pharmaceutical and food industries. Among these bioactives, carotenoids could be highlighted due to their health-promoting effects, including anti-inflammatory, neuroprotective or antioxidant properties. In this study, diverse microalgae extracts enriched in carotenoids, including extracts from Haematococcus pluvialis, Nannochloropsis oceanica, Tisochrysis lutea and Porphyridium cruentum, were evaluated through a battery of in vitro neuroprotective assays in an effort to estimate their potential against neurological disorders. Results indicated that microalgae extracts exerted a moderate and selective cholinesterase inhibitory potential, as well as high antioxidant and anti-inflammatory capacities, highlighting N. oceanica and T. lutea extracts. In parallel, cytotoxicity tests and evaluation of the anti-inflammatory capacity of the microalgae extracts were performed using different models. In this regard, N. oceanica extract showed the highest inhibition of pro-inflammatory cytokine release, indicating that this microalga extract could be the most promising neuroprotective agent.
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