Microcystin-LR in Primary Liver Cancers: An Overview

The cyanobacterial blooms produced by eutrophic water bodies have become a serious environmental issue around the world. After cellular lysing or algaecide treatment, microcystins (MCs), which are regarded as the most frequently encountered cyanobacterial toxins in fresh water, are released into water. Among all the variants of MCs, MC-LR has been widely studied due to its severe hepatotoxicity. Since 1992, various studies have identified the important roles of MC-LR in the origin and progression of primary liver cancers (PLCs), although few reviews have focused on it. Therefore, this review aims to summarize the major achievements and shortcomings observed in the past few years. Based on the available literature, the mechanisms of how MC-LR induces or promotes PLCs are elucidated in this review. This review aims to enhance our understanding of the role that MC-LR plays in PLCs and provides a rational approach for future applications.

Automated summary

Cyanobacterial blooms caused by eutrophic water bodies are a serious global environmental issue. After cellular lysing or algaecide treatment, microcystins (MCs), particularly MC-LR, are released into water, posing severe hepatotoxicity. This review summarizes the major achievements and shortcomings observed in understanding the role of MC-LR in primary liver cancers (PLCs) in recent years. It elucidates the mechanisms of how MC-LR induces or promotes PLCs and provides a rational approach for future applications.