期刊
POLYMERS
卷 14, 期 17, 页码 -出版社
MDPI
DOI: 10.3390/polym14173558
关键词
chitooligosaccharides; chitin; chitosan; anti-inflammatory; antioxidant; tissue engineering; wound healing; antimicrobial; drug delivery; antitumor
This review provides an overview of the characteristics and preparation methods of chitooligosaccharides, and highlights their potential and recent research progress in pharmacology and medical applications.
Chitooligosaccharides, also known as chitosan oligomers or chitooligomers, are made up of chitosan with a degree of polymerization (DP) that is less than 20 and an average molecular weight (MW) that is lower than 3.9 kDa. COS can be produced through enzymatic conversions using chitinases, physical and chemical applications, or a combination of these strategies. COS is of significant interest for pharmacological and medical applications due to its increased water solubility and non-toxicity, with a wide range of bioactivities, including antibacterial, anti-inflammatory, anti-obesity, neuroprotective, anticancer, and antioxidant effects. This review aims to outline the recent advances and potential applications of COS in various diseases and conditions based on the available literature, mainly from preclinical research. The prospects of further in vivo studies and translational research on COS in the medical field are highlighted.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据