期刊
POLYMERS
卷 14, 期 18, 页码 -出版社
MDPI
DOI: 10.3390/polym14183792
关键词
chitosan; graphene; biomaterials; electrical conductivity; cellular adhesion; inflammatory reaction
资金
- Russian Foundation for the Basic Research Grant [2033-90189]
- Ministry of Science and Higher Education [0273-2021-0007]
- Russian Science Foundation [18-15-00401]
Chitosan/graphene nanocomposite films with tunable properties were successfully synthesized for conductive tissue engineering. The films exhibited comparable electrical conductivity, mechanical properties, and biocompatibility to smooth muscle tissue, without releasing soluble cytotoxic components.
Chitosan (CS)/graphene nanocomposite films with tunable biomechanics, electroconductivity and biocompatibility using polyvinylpyrrolidone (PVP) and Pluronic F108 (Plu) as emulsion stabilizers for the purpose of conductive tissue engineering were successfully obtained. In order to obtain a composite solution, aqueous dispersions of multilayered graphene stabilized with Plu/PVP were supplied with CS at a ratio of CS to stabilizers of 2:1, respectively. Electroconductive films were obtained by the solution casting method. The electrical conductivity, mechanical properties and in vitro and in vivo biocompatibility of the resulting films were assessed in relation to the graphene concentration and stabilizer type and they were close to that of smooth muscle tissue. According to the results of the in vitro cytotoxicity analysis, the films did not release soluble cytotoxic components into the cell culture medium. The high adhesion of murine fibroblasts to the films indicated the absence of contact cytotoxicity. In subcutaneous implantation in Wistar rats, we found that stabilizers reduced the brittleness of the chitosan films and the inflammatory response.
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