期刊
POLYMERS
卷 14, 期 17, 页码 -出版社
MDPI
DOI: 10.3390/polym14173545
关键词
polymeric nanocarriers; polymersomes; nanosized hydrogels; cubosomes; ocular; parenteral
资金
- King Khalid University, Abha, Saudi Arabia [R.G.P.2/7/43]
Polymeric nanocarriers have great potential as a delivery vehicle in biomedical applications, but only a few have been approved by regulations. This review discusses the historical development, applications, safety issues, and future research directions of polymeric nanocarriers.
Scientists are focusing immense attention on polymeric nanocarriers as a prominent delivery vehicle for several biomedical applications including diagnosis of diseases, delivery of therapeutic agents, peptides, proteins, genes, siRNA, and vaccines due to their exciting physicochemical characteristics which circumvent degradation of unstable drugs, reduce toxic side effects through controlled release, and improve bioavailability. Polymers-based nanocarriers offer numerous benefits for in vivo drug delivery such as biocompatibility, biodegradability, non-immunogenicity, active drug targeting via surface modification, and controlled release due to their pH-and thermosensitive characteristics. Despite their potential for medicinal use, regulatory approval has been achieved for just a few. In this review, we discuss the historical development of polymers starting from their initial design to their evolution as nanocarriers for therapeutic delivery of drugs, peptides, and genes. The review article also expresses the applications of polymeric nanocarriers in the pharmaceutical and medical industry with a special emphasis on oral, ocular, parenteral, and topical application of drugs, peptides, and genes over the last two decades. The review further examines the practical, regulatory, and clinical considerations of the polymeric nanocarriers, their safety issues, and directinos for future research.
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