期刊
POLYMERS
卷 14, 期 19, 页码 -出版社
MDPI
DOI: 10.3390/polym14194128
关键词
copolymer; NIPAm; acrylamide; curcumin delivery; pH and temperature stimuli; cancer therapy
资金
- National Research Foundation of Korea (NRF) - Ministry of Education [2020R1I1A3052258]
- Technology development Program - Ministry of SMEs and Startups (MSS, Republic of Korea) [S3060516]
- Korea Technology & Information Promotion Agency for SMEs (TIPA) [S3060516] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
In this study, a dual pH- and thermo-sensitive copolymer hydrogel system was prepared and characterized. The hydrogel showed temperature-responsive drug release behavior and high drug loading efficiency. It demonstrated good biocompatibility on liver cancer cells, making it a potential drug delivery carrier for solid tumor-targeted therapy.
Stimuli-response polymeric nanoparticles have emerged as a carrier system for various types of therapeutic delivery. In this study, we prepared a dual pH- and thermo-sensitive copolymer hydrogel (HG) system (PNIPAm-co-PAAm HG), using N-isopropyl acrylamide (NIPAm) and acrylamide (AAm) as comonomers. The synthesized PNIPAm-co-PAAm HG was characterized using various instrumental characterizations. Moreover, the PNIPAm-co-PAAm HG's thermoresponsive phase transition behavior was investigated, and the results showed that the prepared HG responds to temperature changes. In vitro drug loading and release behavior of PNIPAm-co-PAAm HG was investigated using Curcumin (Cur) as the model cargo under different pH and temperature conditions. The PNIPAm-co-PAAm HG showed pH and temperature-responsive drug release behavior and demonstrated about 65% Cur loading efficiency. A nearly complete release of the loaded Cur occurred from the PNIPAm-co-PAAm HG over 4 h at pH 5.5 and 40 degrees C. The cytotoxicity study was performed on a liver cancer cell line (HepG2 cells), which revealed that the prepared PNIPAm-co-PAAm HG showed good biocompatibility, suggesting that it could be applied as a drug delivery carrier. Moreover, the in vitro cytocompatibility test (MTT assay) results revealed that the PNIPAm-co-PAAm HG is biocompatible. Therefore, the PNIPAm-co-PAAm HG has the potential to be useful in the delivery of drugs in solid tumor-targeted therapy.
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