4.7 Article

Inhibition of vaccinia virus L1 N-myristoylation by the host N-myristoyltransferase inhibitor IMP-1088 generates non-infectious virions defective in cell entry

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Summary: Protein lipidation is a widespread post-translational modification in nature that regulates protein function, structure, and subcellular localization. Lipid transferases and their substrate proteins are of interest as drug targets due to their dysregulation in disease. The hydrophobic and dynamic nature of lipid modifications poses challenges for detection, but chemical proteomics offers a powerful approach to identify and quantify them.

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