期刊
PLOS COMPUTATIONAL BIOLOGY
卷 18, 期 9, 页码 -出版社
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pcbi.1010477
关键词
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资金
- JSPS KAKENHI [19K16096, JP18H04760, JP18K13515, JP19H05275, JP19H05795]
- Human Frontier Science Program [RGY0081/2019]
- HHMI Scholar award [55108527]
- NIH [R01AR063663, R01AR072668, DP1AG066590]
- Canadian Institutes of Health Research
- New York Stem Cell Foundation Druckenmiller Fellow
This article demonstrates the potential application of graph neural network (GNN) models in predicting cell fate and inferring cell interactions in tissues. By analyzing live mammalian epidermis data, GNN discovers neighbor cell fate coordination rules that vary across different regions of the body.
Robustness in developing and homeostatic tissues is supported by various types of spatiotemporal cell-to-cell interactions. Although live imaging and cell tracking are powerful in providing direct evidence of cell coordination rules, extracting and comparing these rules across many tissues with potentially different length and timescales of coordination requires a versatile framework of analysis. Here we demonstrate that graph neural network (GNN) models are suited for this purpose, by showing how they can be applied to predict cell fate in tissues and utilized to infer the cell interactions governing the multicellular dynamics. Analyzing the live mammalian epidermis data, where spatiotemporal graphs constructed from cell tracks and cell contacts are given as inputs, GNN discovers distinct neighbor cell fate coordination rules that depend on the region of the body. This approach demonstrates how the GNN framework is powerful in inferring general cell interaction rules from live data without prior knowledge of the signaling involved.
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