4.5 Article

Suppression of obesity by melatonin through increasing energy expenditure and accelerating lipolysis in mice fed a high-fat diet

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NUTRITION & DIABETES
卷 12, 期 1, 页码 -

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SPRINGERNATURE
DOI: 10.1038/s41387-022-00222-2

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  1. Natural Science Foundation of Zhejiang Province, China [LY21H070004]
  2. National Natural Science Foundation of China [81900778]
  3. Wenzhou Municipal Science and Technology Bureau [Y20190049]
  4. High-Level Innovation Team of Universities in Zhejiang Province [604090352/610]

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This study found that melatonin can suppress obesity and insulin resistance caused by a high-fat diet by increasing brown adipose tissue activity and promoting energy expenditure. These effects may be mediated by the regulation of fibroblast growth factor 21.
Backgrounds/objectives Melatonin promotes brown adipose tissue (BAT) activity, leading to body mass reduction and energy expenditure. However, the mechanisms governing these beneficial effects are not well-established. This study aimed to assess the effects of (1) melatonin on BAT and energy metabolism, and (2) fibroblast growth factor 21 (FGF21) in BAT-mediated thermogenesis. Methods Male C57BL/6 J mice received a high-fat diet (HFD) or normal chow, accompanied by intraperitoneal injection of 20 mg/kg melatonin for 12 weeks. FGF21(-/-) mice consumed an HFD with or without melatonin for 8 weeks. Results Melatonin attenuated weight gain, insulin resistance, adipocyte hypertrophy, inflammation, and hepatic steatosis induced by the HFD and increased energy expenditure. Furthermore, melatonin improved cold tolerance by increasing BAT uncoupling protein 1 (UCP1) expression and producing heat. Notably, melatonin resulted in a shift in energy metabolism favouring the utilization of fat, and it increased FGF21 in circulating and metabolic tissues and skeletal muscle phosphorylation of AMP-activated protein kinase. However, melatonin did not protect against obesity, insulin resistance, and energy expenditure in HFD-fed FGF21(-/-) mice. Conclusions Melatonin suppressed obesity and insulin resistance resulting from the HFD by enhancing BAT activity and energy expenditure, and these effects were dependent on FGF21.

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