期刊
JOURNAL OF INNOVATIVE OPTICAL HEALTH SCIENCES
卷 15, 期 6, 页码 -出版社
WORLD SCIENTIFIC PUBL CO PTE LTD
DOI: 10.1142/S1793545822300099
关键词
Photodynamic therapy; photosensitizer; cerium; reactive oxygen species
资金
- National Natural Science Foundation (NNSF) of China [52103166, 61935004]
- Natural Science Foundation (NSF) of Jiangsu Province [BK20200710]
- Jiangsu Postdoctoral Science Foundation [51204087]
- NSF of Shandong Province [ZR2020KB018]
- Taishan ScholarsConstruction Special Fund of Shandong Province
- Natural Science Foundation of Ningbo [202003N40448]
- Open Project Program of Wuhan National Laboratory for Optoelectronics [2020WNLOKF022]
This review discusses the recent advances in the use of cerium-based nanoparticles as novel photosensitizers for cancer photodynamic therapy (PDT), including the activation mechanisms for electron transfer to generate singlet oxygen. The types of cerium-based nanoparticles used for cancer PDT are summarized, and the challenges and prospects of clinical translations of cerium-based nanoparticles are briefly addressed.
Metal- and metal-oxide-based nanoparticles have been widely exploited in cancer photodynamic therapy (PDT). Among these materials, cerium-based nanoparticles have drawn extensive attention due to their superior biosafety and distinctive physicochemical properties, especially the reversible transition between the valence states of Ce(III) and Ce(IV). In this review, the recent advances in the use of cerium-based nanoparticles as novel photosensitizers for cancer PDT are discussed, and the activation mechanisms for electron transfer to generate singlet oxygen are presented. In addition, the types of cerium-based nanoparticles used for PDT of cancer are summarized. Finally, the challenges and prospects of clinical translations of cerium-based nanoparticles are briefly addressed.
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