Study on the Mechanism of Huanglian Jiedu Decoction in Treating Dyslipidemia Based on Network Pharmacology

Article Biochemistry & Molecular Biology

Apolipoprotein E content of VLDL limits LPL-mediated triglyceride hydrolysis

Brynne E. Whitacre et al.

Summary: High levels of circulating triglycerides are associated with metabolic diseases. This study found that APOE on VLDL modulates LPL activity, which may be relevant to the pathogenesis of metabolic diseases.

JOURNAL OF LIPID RESEARCH (2022)

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Review Pharmacology & Pharmacy

Contemporary Management of Dyslipidemia

Richard A. Ferraro et al.

Summary: The treatment of dyslipidemia continues to be a controversial topic, and understanding appropriate lipid-lowering therapy is essential for practitioners across medical specialties. This review provides recent research developments and recommendations for dyslipidemia patients, aiming to better inform clinical practice.

DRUGS (2022)

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Review Environmental Sciences

Therapeutic potential of herbal medicine for the management of hyperlipidemia: latest updates

Abdur Rauf et al.

Summary: This article reviews the risk factors of dyslipidemia, synthetic medication, and the potential of medicinal plants in treating hyperlipidemia. Traditional Chinese herbal medicine and combination therapy show promise in lowering high cholesterol levels.

ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH (2022)

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Article Integrative & Complementary Medicine

Effects of Erchen Decoction on Oxidative Stress-Related Cytochrome P450 Metabolites of Arachidonic Acid in Dyslipidemic Mice with Phlegm-Dampness Retention Syndrome: A Randomized, Controlled Trial on the Correspondence between Prescription and Syndrome

Jing Chen et al.

Summary: In this study, it was found that Erchen decoction can reverse blood lipid abnormalities and improve oxidative stress-related metabolites in mice with dyslipidemia and phlegm-dampness retention syndrome through regulating the CYP450 pathways of arachidonic acid metabolism.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2022)

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Review Biochemistry & Molecular Biology

Leptin Signaling in Obesity and Colorectal Cancer

Claudia Terezia Socol et al.

Summary: Obesity and colorectal cancer are major diseases causing deaths worldwide, with complex pathology. Leptin, an important adipokine related to obesity, plays a significant role in the development of colorectal cancer. However, the current data on the relationship between leptin and obesity and colorectal cancer are inconsistent and insufficient, calling for further research to better understand this association.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Biology

Efficacy and Safety of Da-Chai-Hu-Tang in Lipid Profiles in High-Risk, Statin-Treated Patients with Residual HyperTG: A 12-Week, Randomized, Active-Control, Open Clinical Study

Young-Shin Lee et al.

Summary: This study evaluated the efficacy and safety of DCHT in high-risk, statin-treated patients with residual hypertriglyceridemia. The results showed that DCHT was as effective as OMEGA3 in reducing triglyceride levels.

LIFE-BASEL (2022)

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Review Cardiac & Cardiovascular Systems

Landscape of cardiometabolic risk factors in Chinese population: a narrative review

Jian-Jun Li et al.

Summary: China is facing a cardiovascular disease crisis due to rapid economic growth and changes. The prevalence of cardiometabolic risk factors has increased over the past decades, leading to a rise in deaths from cardiovascular diseases. This narrative review provides an updated overview of the epidemiology of cardiometabolic risk factors in China and discusses strategies to tackle this pandemic. Effective interventions and treatments for these risk factors are also highlighted in this review.

CARDIOVASCULAR DIABETOLOGY (2022)

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Article Surgery

Epidemiology of Coronary Artery Disease

John P. Duggan et al.

SURGICAL CLINICS OF NORTH AMERICA (2022)

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Article Cardiac & Cardiovascular Systems

Global Burden Attributable to High Low-Density Lipoprotein-Cholesterol From 1990 to 2019

Heyue Du et al.

Summary: This study reveals the global burden of high LDL-C and finds that while the overall burden of high LDL-C has been controlled in the past 30 years, it is still increasing in countries with moderate SDI and the decreasing trend is disappearing in high SDI countries.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2022)

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Article Chemistry, Medicinal

Natural products and analogs as preventive agents for metabolic syndrome via peroxisome proliferator-activated receptors: An overview

Carlos Villarroel-Vicente et al.

Summary: Natural products and synthetic analogs are potential therapeutic drugs for metabolic syndrome by activating the transcriptional activity of PPARs and managing obesity, diabetes, dyslipidemia, and non-fatty liver disease. Compounds like quercetin, resveratrol, and curcumin have shown beneficial effects on patients. Further large-scale clinical trials may be needed for promising compounds.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2021)

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Review Chemistry, Medicinal

Promising influences of Scutellaria baicalensis and its two active constituents, baicalin, and baicalein, against metabolic syndrome: A review

Vafa Baradaran Rahimi et al.

Summary: Studies have shown that Scutellaria baicalensis and its active constituents, baicalin and baicalein, have promising effects on controlling metabolic syndrome and related disorders such as obesity, hyperlipidemia, atherosclerosis, diabetes, and their subsequent complications by regulating key signaling pathways in glucose and lipid metabolism.

PHYTOTHERAPY RESEARCH (2021)

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Article Health Care Sciences & Services

Network Pharmacology Analysis on the Mechanism of Huangqi Sijunzi Decoction in Treating Cancer-Related Fatigue

Yixin Cui et al.

Summary: The study identified that the active ingredients in HQSJZD, including quercetin, luteolin, kaempferol, and naringenin, may target important genes such as AKT1, IL-6, VEGFA, and pathways like PI3K-Akt and TNF to suppress inflammatory response, tumor gene expression, and tumor angiogenesis in treating CRF. This systematic pharmacological study provides valuable insights for understanding the anti-CRF mechanism of HQSJZD and offers a methodological protocol for future similar studies.

JOURNAL OF HEALTHCARE ENGINEERING (2021)

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Article Cell Biology

Geniposide Ameliorated Dexamethasone-Induced Cholesterol Accumulation in Osteoblasts by Mediating the GLP-1R/ABCA1 Axis

Yizhou Zheng et al.

Summary: Geniposide (GEN) alleviates dexamethasone (DEX)-induced cholesterol accumulation and inhibition of cell differentiation by mediating the GLP-1R/ABCA1 axis in MC3T3-E1 cells.

CELLS (2021)

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Article Integrative & Complementary Medicine

Metabonomic Study on the Plasma of High-Fat Diet-Induced Dyslipidemia Rats Treated with Ge Gen Qin Lian Decoction by Ultrahigh-Performance Liquid Chromatography-Mass Spectrometry

Ziwei Xu et al.

Summary: Gegen Qinlian decoction (GGQLD) has a significant therapeutic effect on dyslipidemia, reducing blood lipids and improving symptoms by modulating endogenous metabolites through various metabolic pathways.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2021)

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Review Chemistry, Medicinal

Quercetin and metabolic syndrome: A review

Azar Hosseini et al.

Summary: Quercetin, as an important flavonoid, has potential effects in improving symptoms of metabolic syndrome, but further research and clinical trials are needed to determine its true clinical value.

PHYTOTHERAPY RESEARCH (2021)

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Article Physiology

Huang-Lian-Jie-Du Decoction Attenuates Atherosclerosis and Increases Plaque Stability in High-Fat Diet-Induced ApoE-/- Mice by Inhibiting M1 Macrophage Polarization and Promoting M2 Macrophage Polarization

Yinhe Cai et al.

Summary: Huang-Lian-Jie-Du Decoction attenuates atherosclerosis and promotes plaque stability by suppressing M1 polarization and enhancing M2 polarization.

FRONTIERS IN PHYSIOLOGY (2021)

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Article Biochemistry & Molecular Biology

Kaempferol ameliorates symptoms of metabolic syndrome by improving blood lipid profile and glucose tolerance

Ayasa Ochiai et al.

Summary: KPF has beneficial effects on obesity, dyslipidemia, and diabetes, potentially by increasing LDLR and ApoA1 expression to lower LDL and raise HDL levels, while also improving glucose tolerance by reducing resistin.

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY (2021)

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Article Plant Sciences