期刊
JOURNAL OF DIABETES
卷 14, 期 9, 页码 586-595出版社
WILEY
DOI: 10.1111/1753-0407.13303
关键词
aging; cytokines; diabetes; keratinocytes; permeability barrier; stratum corneum hydration
资金
- National Institute of Arthritis and Musculoskeletal and Skin Diseases [AR061106]
Epidermal function is influenced by various exogenous and endogenous factors, and changes in epidermal function in type 2 diabetes could exacerbate cutaneous inflammation. Therefore, improving epidermal function could be an alternative approach to mitigating type 2 diabetes and associated skin disorders.
Epidermal function is regulated by numerous exogenous and endogenous factors, including age, psychological stress, certain skin disorders, ultraviolet irradiation and pollution, and epidermal function itself can regulate cutaneous and extracutaneous functions. The biophysical properties of the stratum corneum reflect the status of both epidermal function and systemic conditions. Type 2 diabetes in both murine models and humans displays alterations in epidermal functions, including reduced levels of stratum corneum hydration and increased epidermal permeability as well as delayed permeability barrier recovery, which can all provoke and exacerbate cutaneous inflammation. Because inflammation plays a pathogenic role in type 2 diabetes, a therapy that improves epidermal functions could be an alternative approach to mitigating type 2 diabetes and its associated cutaneous disorders.
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