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Article
Health Care Sciences & Services
Justin R. Kingery et al.
Summary: This study examined the health status, persistent symptoms, and effort tolerance approximately 1 year after COVID-19 infection and found that post-acute COVID-19 sequelae (PASC) are very common during this time period and severe enough to impact daily exercise tolerance. PASC symptoms are widely distributed, not limited to a specific patient group, and unrelated to age.
JOURNAL OF GENERAL INTERNAL MEDICINE
(2022)
Review
Infectious Diseases
Joan B. Soriano et al.
Summary: People with COVID-19 might experience long-term symptoms known as long COVID or long-haul COVID. The lack of a standardized definition hinders the understanding and treatment of this condition. In a WHO-led Delphi process, a consensus definition was developed, stating that post-COVID-19 condition occurs in individuals with a history of SARS-CoV-2 infection, with symptoms lasting for at least 2 months and impacting everyday functioning. This common framework provides a foundation for future studies and therapy.
LANCET INFECTIOUS DISEASES
(2022)
Review
Immunology
Felicia Ceban et al.
Summary: Post-COVID-19 syndrome, characterized by persistent symptoms after resolution of acute infection, is associated with significant fatigue and cognitive impairment. This study aimed to quantify the proportion of individuals experiencing fatigue and cognitive impairment 12 or more weeks after COVID-19 diagnosis, and to explore the inflammatory and functional consequences of post-COVID-19 syndrome. The results showed that a significant proportion of individuals continue to experience fatigue and cognitive impairment even after 12 or more weeks of COVID-19 diagnosis. Additionally, some individuals showed elevated levels of inflammatory markers and significant functional impairment.
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Article
Virology
Sonja Ludwig et al.
Summary: This study examines the impact of COVID-19 on the olfactory, gustatory, hearing, and vestibular systems. The results indicate that patients may experience olfactory and gustatory impairments for up to six months after COVID-19, while balance disorders are less common. Clinical tests revealed that approximately 75% of patients had hyposomnia/anosmia and 20% experienced mild hypogeusia for the same duration. Vestibular disorders and hearing impairment were rare. Females were more significantly affected by sensory impairments than males.
Article
Medicine, General & Internal
Tim J. Hartung et al.
Summary: This study aimed to assess the frequency and associated factors of fatigue and cognitive impairment after COVID-19. The results showed that fatigue was more common in COVID-19 patients, especially in females, younger individuals, those with a history of depression, and those with more acute COVID-19 symptoms. Cognitive impairment was also a common sequelae of COVID-19, and it was associated with older age, male gender, lower education level, and a history of neuropsychiatric disease. There was no significant correlation between fatigue and cognitive impairment, and only a small percentage of patients experienced both conditions.
Article
Medicine, General & Internal
Ma Pilar Rodriguez-Perez et al.
Summary: This study aimed to identify the impact of symptom persistence as well as clinical and socio-demographic variables in individuals with Long COVID. The results showed that individuals with Long COVID exhibited moderate dependency status and functional limitations. Older age and the presence of neurological symptoms, such as dizziness and headaches, were associated with a higher degree of dependency. Dependency status improved with increasing time since diagnosis.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Microbiology
Ben Hu et al.
Summary: This review summarizes the research progress on SARS-CoV-2 and COVID-19, including virology characteristics, pathogenesis, and recent advances in treatment methods. Furthermore, it discusses in detail the potential wildlife hosts and zoonotic origin of this emerging virus.
NATURE REVIEWS MICROBIOLOGY
(2021)
Article
Infectious Diseases
Kiva A. Fisher et al.
Summary: This study compared symptoms, duration of illness, and health-related quality of life between COVID-19 cases and controls, finding that COVID-19 patients were more likely to experience persistent symptoms and poorer physical health. Loss of taste or smell was strongly associated with COVID-19. Thus, widespread diagnostic testing is necessary to distinguish COVID-19 from other acute illnesses.
INFLUENZA AND OTHER RESPIRATORY VIRUSES
(2021)
Article
Public, Environmental & Occupational Health
Jutta Lindert et al.
Summary: The COVID-19 pandemic has had a complex and varied impact on mental health, potentially leading to new symptoms, exacerbation of pre-existing mental disorders, and the development of symptoms that may not meet diagnostic criteria. Factors such as demographic, social, economic, mental, and relationship factors contribute to mental health issues related to the pandemic. Attention needs to be paid to addressing these issues in order to provide appropriate support.
EUROPEAN JOURNAL OF PUBLIC HEALTH
(2021)
Article
Public, Environmental & Occupational Health
Sarah Cuschieri et al.
Summary: Individuals with chronic diseases are more susceptible to grave complications and negative outcomes if infected by COVID-19. Mandatory isolation and cancellations of routine healthcare services disrupt screening and management plans for chronic diseases. Fear of attending health services and disruptions to public transport increase health risks among persons with chronic conditions during the pandemic.
EUROPEAN JOURNAL OF PUBLIC HEALTH
(2021)
Article
Respiratory System
Knut Stavem et al.
Summary: The study assessed symptoms and their determinants 1.5-6 months after symptom onset in non-hospitalised subjects with confirmed COVID-19 until 1 June 2020. Findings showed that individuals reported fewer symptoms after 1.5-6 months compared to during the acute COVID-19 phase, with persistent symptoms being associated with the number of comorbidities and symptoms experienced during the acute phase.
Article
Virology
Emma Lofstrom et al.
Summary: In this study, the maturation of IgG avidity and antibody levels over time in patients with PCR-confirmed non-severe Covid-19 was investigated. The results showed a significant increase in total n-antibodies from 1 to 3 months post-infection, followed by a significant decrease from 3 to 6 months. Meanwhile, a decrease in IgG anti-spike levels and an increase in IgG-avidity index were observed, suggesting a potential aspect of long-term immunity post Covid-19.
JOURNAL OF CLINICAL VIROLOGY
(2021)
Review
Immunology
Anders Tegnell
Summary: The Swedish COVID-19 response has garnered excessive attention despite not having distinctively different goals or features compared to other countries. The overall response has involved almost all sectors of society, and this paper provides a general, brief description from a public health perspective, offering a somewhat more nuanced picture of Sweden's efforts to combat COVID-19.
Article
Medicine, General & Internal
Helen Humphreys et al.
Summary: This qualitative study explores the lived experience of long COVID, specifically focusing on the role of physical activity. Findings show that individuals with long COVID struggle with reduced physical function, cognitive and psychological effects of the virus, and challenges in finding tailored advice about physical activity. Managing symptoms, such as fatigue and 'brain fog', while trying to resume and maintain daily activities and exercise is crucial for their well-being.
Article
Multidisciplinary Sciences
Yan Xie et al.
Summary: The study analyzed data from the US Department of Veterans Affairs healthcare databases to estimate the burden of Post-Acute Sequelae of SARS-CoV-2 infection (PASC), finding approximately 73.43 PASC cases per 1000 persons at 6 months. The burden of PASC varied by demographic groups and baseline health status, with more severe acute infection leading to higher burden. The study highlights the substantial burden of PASC and the importance of considering different population groups when planning healthcare strategies.
NATURE COMMUNICATIONS
(2021)
Article
Public, Environmental & Occupational Health
Christina Lemhoefer et al.
Summary: Long-term symptoms after mild and moderate COVID-19 are common and can lead to limitations in activities and participation, but in most cases they do not severely impact quality of life or work ability.
JOURNAL OF OCCUPATIONAL MEDICINE AND TOXICOLOGY
(2021)
Letter
Medicine, General & Internal
Sebastian Havervall et al.
Summary: This study found that COVID-19-related symptoms can persist for 8 months among Swedish health care workers, and these symptoms have effects on their home, work, and social functions.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2021)
Article
Medicine, General & Internal
Xue Zhang et al.
Summary: This study found that patients with severe disease during hospitalization for COVID-19 had more post-infection symptoms and higher CAT scores at 1-year follow-up. Older age, female sex, and severe disease were identified as risk factors for fatigue, while severe disease and older age were associated with having at least 3 symptoms.
Article
Nursing
Wenxiu Sun et al.
Summary: COVID-19 infection can cause psychological distress, but can also lead to positive changes, such as reevaluating life priorities, improving social relationships, and enhancing personal growth awareness.
CLINICAL NURSING RESEARCH
(2021)
Article
Microbiology
Harald Brussow et al.
Summary: COVID-19 is an acute respiratory infection that can have long-term sequelae, leading to "long covid". This disease will leave long-lasting scars on society.
ENVIRONMENTAL MICROBIOLOGY
(2021)
Article
Multidisciplinary Sciences
Sandra Lopez-Leon et al.
Summary: This study aimed to identify studies assessing the long-term effects of COVID-19, estimating that 80% of infected patients will develop one or more long-term symptoms, with the most common being fatigue, headache, attention disorder, hair loss, and dyspnea.
SCIENTIFIC REPORTS
(2021)
Review
Medicine, General & Internal
Harry Crook et al.
Summary: The long-term effects of covid-19 can affect multiple systems in the body, leading to persistent symptoms that impact patients of varying severity. These symptoms include fatigue, dyspnea, and cognitive impairment, among others. Studies discuss risk factors for acute and long covid, as well as potential therapeutic options.
BMJ-BRITISH MEDICAL JOURNAL
(2021)
Article
Environmental Sciences
Jeannet M. Delbressine et al.
Summary: Patients with persistent symptoms after COVID-19 may still demonstrate a significantly decreased walking time six months after symptom onset. Further research is needed to investigate long-term consequences and potential treatment options to guide patients during recovery from COVID-19.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Primary Health Care
Nalinakumari Kesavan Nair Anjana et al.
Summary: The study found that post COVID syndrome may occur in COVID-19 patients with minimal symptoms, with fatigue, headache, myalgia, joint pain, and exertional dyspnea being the main symptoms. Factors like the presence of fatigue, cough, and breathlessness at admission, as well as having another COVID-positive family member, were significantly associated with the appearance of post-COVID symptoms.
JOURNAL OF FAMILY MEDICINE AND PRIMARY CARE
(2021)
Article
Medicine, General & Internal
Lovisa Hellgren et al.
Summary: A study in Sweden investigated the long-term effects of COVID-19 on brain MRI and neurocognitive function in high-risk patients, finding that most patients had abnormal MRI findings or impaired neurocognitive function, along with reported fatigue.
Article
Respiratory System
Liam Townsend et al.
Summary: This study reveals that some patients still experience respiratory diseases and subjective symptoms after COVID-19 infection, with ongoing health issues and fatigue often accompanied by a higher perception of exertion. Initial disease severity does not have a strong correlation with persistent respiratory diseases.
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2021)
Article
Health Care Sciences & Services
Max Augustin et al.
Summary: The study observed long-term symptoms in non-hospitalised patients post SARS-CoV-2 infection for four and seven months, identifying persistent symptoms such as shortness of breath, anosmia, ageusia, and fatigue, summarised as post-COVID syndrome (PCS).
LANCET REGIONAL HEALTH-EUROPE
(2021)
Article
Respiratory System
Enya Daynes et al.
Summary: Recovery programmes for individuals with lasting symptoms of COVID-19 can significantly improve exercise capacity, respiratory symptoms, fatigue, and cognition, with no serious adverse events recorded.
CHRONIC RESPIRATORY DISEASE
(2021)
Review
Rehabilitation
Francesco Agostini et al.
Summary: An integrated rehabilitative approach is recommended for COVID-19 patients, involving a multidisciplinary team providing neuromuscular, cardiac, respiratory, and swallowing interventions, as well as psychological support, to improve patients' quality of life. The involvement of a physician expert in rehabilitation is key, with a dedicated intervention set up after thorough assessment of the patient's clinical condition in collaboration with all rehabilitation team professionals.
JOURNAL OF REHABILITATION MEDICINE
(2021)
Article
Medicine, Research & Experimental
Laura Di Renzo et al.
JOURNAL OF TRANSLATIONAL MEDICINE
(2020)
Article
Education, Scientific Disciplines
Ulla H. Graneheim et al.
NURSE EDUCATION TODAY
(2017)
Article
Public, Environmental & Occupational Health
Kathleen T. Galvin et al.
INTERNATIONAL JOURNAL OF QUALITATIVE STUDIES ON HEALTH AND WELL-BEING
(2011)
Article
Health Care Sciences & Services
Allison Tong et al.
INTERNATIONAL JOURNAL FOR QUALITY IN HEALTH CARE
(2007)
Article
Education, Scientific Disciplines
UH Graneheim et al.
NURSE EDUCATION TODAY
(2004)
